DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and ubr-5

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_492389.1	Gene:	ubr-5 / 172697	WormBaseID:	WBGene00009460	Length:	2944	Species:	Caenorhabditis elegans

Alignment Length:	3323	Identity:	822/3323 - (24%)
Similarity:	1285/3323 - (38%)	Gaps:	931/3323 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VKEVVIGPAHIGVLLEDGKAFRVSFSINSEKLDLTKSDAKCSTSGGSGTASASKAPSSSR----- 106
            :::||:||.|:||||:|....|:.:.:    |.:...:.|        .|.|.|...|||
Worm    71 IRQVVLGPKHVGVLLDDATVCRIPYHV----LQIQSGEVK--------EAEAVKGEPSSRLHDVY 123

  Fly   107 ------------PMARSRARLLRATGRSNSTGQGSGSRSTGVIIGGSTSSRPLV----TVPATYV 155
                        |::.....|..|.|::........:|:...:.|....||..|    .||||.|
Worm   124 ARAGAAGEVEVIPLSGGMNTLRAAAGQAKYRRVMLSNRAYYRLRGNLGESRSYVLGAPRVPATNV 188

  Fly   156 PEELISQAEVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEEAEDT-EEGADNYVPEDLISL 219
            |||||:..:.|||||||::||||||||.|:||.||||||||||.:.:|. :.|.::.:||:|:.:
Worm   189 PEELINNVQQVLQGKSRDVIIRELQRTGLNVNEAVNNLLSRDDGDEQDVLDVGGEHLIPEELLQI 253

  Fly   220 LDNGFSGDNNSVIIDPSDGLFSEEIFSNYSSIRNLLFDRIRSERSNANANAADSNQSTTRSTSSG 284
            |:.|         :.|
Worm   254 LEGG---------VPP------------------------------------------------- 260

  Fly   285 TALTGNSGLSAQISVNADRE------AFSRWRDRQYYGPRRWISKDDYTWEKDADSKKKEPSPML 343
                |:||..|......:||      ..||...|.::|.... ||.....|||...|..|.: ..
Worm   261 ----GSSGAVAMAESLLEREDRLLDSLASRAEMRYHFGGASG-SKKPKANEKDKKKKDSETN-WK 319

  Fly   344 SPIWISEELQPW--------PE--KSSVRFK----------TIGALYSEFIALSESGDLYQWRWS 388
            :.|.:.|.::.|        ||  |:....|          :|.|...:..||..:|.:|.|.|.
Worm   320 NCIQLGEHVEWWRGAPGDGIPEHAKTDAPVKSEDDKANPVISITATSYQMYALHRNGKMYSWAWD 384

  Fly   389 DAEPYKSE---TENVYHP--KTVSLNIVERVELISANFIRCSVVTETNRVATWMDEQLGYIGAKL 448
            ::|.....   .:|..||  .|:..:....:::.|:| :|.|::|.:..:.:|:||    .||.:
Worm   385 ESEGLDDPLTIVKNRDHPDHATIGTHGNPVIQMSSSN-LRISILTRSGHLVSWLDE----CGAGV 444

  Fly   449 EHSCCAFNEFISDSITKIYVCSLYTVVKTESNN----------IYWWGVLPFDQRRFLWDKFRTK 503
            ..|      ..|:::|||...|:..|....:::          |:|.|::|..:......|.:.:
Worm   445 RFS------LASETVTKISEDSVMAVQDLVTSDHLAAFRIDSIIHWCGIVPLVESTRSTKKEKEE 503

  Fly   504 TKKPFK------------VVATDIN-----VGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNS 551
            ..:..|            :.|...|     ||.||.|||.|:|.:||:........|.:|.||..
Worm   504 ADREKKKHVSFGEAPVSSIPAVQSNSIEFFVGQQVQMKKAPLYPAGSVAAQIDTSNPMIGVLLED 568

  Fly   552 VWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTGSSKNGQSFSNSKE 616
            .|:.||.||.:                       .:|| |:......:....:..||.|
Worm   569 CWSATDHCRFR-----------------------SMTP-KEYDYELEVDGFIALLNGAS------ 603

  Fly   617 STDRIDMPPPPSPASSTCSDT--GSVTSHKRTKRATTKEDSNAPQE-GRKDEELWEVKDVVFV-E 677
                    |..|.||.|.:.|  |...|.|||.......:|..|.| ||:..|:|..:|:|:: |
Worm   604 --------PEVSSASGTSTKTLPGGRVSRKRTHDEADDSNSVPPTEFGRRRVEVWLAEDLVWIHE 660

  Fly   678 DKVGPVGKVLKVDGDFVAVR----------FPAINAAAVAAAAAATSSTSNTASTSKEEGKEDDW 732
            .:...|..|..||.:.|||:          |.::.:..:.......:..|...||        |.
Worm   661 HRKRDVMTVQVVDNNLVAVKHVPNSSQKPIFQSLFSERLEMDGMPQTVISIEKST--------DI 717

  Fly   733 QQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVD-------------SR 784
            .:.||:|:||:|:. .....|.|..|||:..|.:|.   ....|:::..|             .|
Worm   718 DKIRLMRKEDLQVI-DKCPPRAPVILQKELLKFDVD---CNRTIVSMVADLNELRVLARSKHVER 778

  Fly   785 GIHVIK-----KVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTI 844
            |:|:.:     ||:.:....::           |...:...|.|.:|..|..       |::.|:
Worm   779 GMHMYRVSTNGKVISRRRVPVF-----------LPSVERPIFGGLSPKLISF-------GDARTL 825

  Fly   845 VLRDGNGALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLPA--MLSGVNLKSKVCMTALLF-- 905
            .|||..|.|.||.:|.|...::|......|:  :.::|...|:  :|:.....|:...:.|:.
Worm   826 FLRDTAGQLIPLQRDALNGFREPPAMHSQPI--LHIATACRPSFNVLASCEKNSQWQGSMLIIPG 888

  Fly   906 -----------DTQKLMPHILRCDVKNSFAALGRL-------------EREDQADTALVVEERCD 946
                       |...||..:|.||.......|.||             .|:..::....:..  |
Worm   889 VDRPWHSHFIKDGSSLMQMVLYCDADGVSQFLDRLFELRMSCTISHHEFRQIMSEQLFTITS--D 951

  Fly   947 GARNIFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSS 1011
            ...|:.||.:.:.:.:.|.:   ||.. .|...::..|...|:|........:...|....:|||
Worm   952 LCSNVLHAAIRLTSATKNSE---DSDK-AVPDTTMPTLFPTRNITLPPQDVSMEDAAPAEESSSS 1012

  Fly  1012 NENSSFATMSSSAAGSASSTSRDNRTNL----RDMMNRLINSDQAEQSGSQ--PMATNNEDHAYI 1070
            |..............|....||..|..:    :....:..:|::.::.|.:  ..:....|.:.:
Worm  1013 NMQGDEIDDEEEPRWSRVLRSRPKREQVTPSKKSKKEKRADSEENDEYGGENHSFSAVRSDESGM 1077

  Fly  1071 PWPAETPAASNLSASSSQNVSDSIEDDISKIIPSSSQSSMLSNIK--LGSPTYTFDLAQRREHAL 1133
            |:.:..|                         |...|.|.|..|.  |..|...:| ....||.
Worm  1078 PFGSPRP-------------------------PMVRQKSALQIIDTFLKHPAMFYD-KDAEEHI- 1115

  Fly  1134 TILQQMCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQ--DPQLKEA 1196
                :....|.....:..:|.|:|..|.|||..:::.|||.|...:...:|.|..|  ..:.|..
Worm  1116 ----EYVDEPDRLSAVKALLLTRDLNGMTPFQSAINQRAYGAATSIWRALLQLGFQTMSEEQKLK 1176

  Fly  1197 MIFPN-----GSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCH 1256
            .|||:     ...||.|||.::||||.|||||||.|||||:|:||||||||||||||:|||..||
Worm  1177 YIFPSFNVDESHNADDSPLFILCYNDVCSFTWTGEDHINQDIYECKTCGLTGSLCCCSECALTCH 1241

  Fly  1257 KGHDCKLKRTAPTAYCDCWEK--CKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFL 1319
            :.|||:||||:||||||||||  |.||||||||...|..||.:|:..|.|....|::.|.|:|||
Worm  1242 RNHDCRLKRTSPTAYCDCWEKSSCNCKALIAGNELLREHLLSELLKYTRLFEYPNARNEHIMLFL 1306

  Fly  1320 IQTVGRQIVEQ-----RQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPK 1379
            .:||.||..||     |:.|:...::...::.|                       |:|:|.|||
Worm  1307 ARTVIRQTREQTYSQKRRSRYRTAMQTSQSSGT-----------------------PEHNLNPPK 1348

  Fly  1380 FARKALERLLIDWNAVRSMIMSGAER---GDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFT 1441
            ||:.|||:...:.|.|.:.|..|..:   .::..|           |...|:| |..||.|||.|
Worm  1349 FAKTALEQCCKNANVVMNSIRCGINKFGQMELATP-----------GQLHFVQ-QSTSTHLDKLT 1401

  Fly  1442 HSLIVKCTSDHLDTLLLTLVRELQNASVSNR--SKEAEEVVRRFVRSVARVFVI-FNL------- 1496
            .:|..|...|: .:|.:..:|.|.:|.:.:.  .::.|..|.|||||:.||..: .|:
Worm  1402 FALSNKILKDY-SSLFVGTLRNLLSAPIRDPRVDQDIEMWVGRFVRSLVRVLTLAINVSPLAPST 1465

  Fly  1497 -----EKQPNPEKRKSHSSCNKYVQSCVKVF-------------------------------QTL 1525
                 :...|...|......::|.|:..:||                               |.|
Worm  1466 ILAAEDPTDNATPRDPREDRSRYNQATFQVFHALVISKKESSKLSEKSASFVAMITRIMQFLQQL 1530

  Fly  1526 HKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLDVRN------SDDLFSVDPLAPS----- 1579
            ...::.:|...::|:..|||.|::||.....::.:|.|..:      :.||...:.|..|
Worm  1531 PTFAVVQLAIAADAIFEPVRDGMLRPMVNPALAGNNHDPMDILEKYFTSDLSFSEVLKRSKKEER 1595

  Fly  1580 ---------------------------NVESPSEQILVHDAGNDQSANFNIQQNYDVVAMETIRD 1617
                                       |.||..::....|..::......|:  :|..|..|:..
Worm  1596 AIATSKPDTKRVRRTSRRDTDRENGSDNRESMEDERSAGDRASESQETLRIR--HDSTATSTVPT 1658

  Fly  1618 ASESEEVINREANSHNQDDELIENQRN--------EDGMQDDESDNDFTFNDAETESDSDDNQSN 1674
            ......:.....|..|:|:|    :||        |....||::|:|...:|.|.:.|.||:..:
Worm  1659 PRRRRLLSGNTTNDTNEDNE----ERNGQPREFDGESSSSDDDNDDDDDDDDEEEDDDDDDDDDD 1719

  Fly  1675 QEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEE------------------DGSEDGE---- 1717
            ::..|.    |....|::      |.|.||...|:|                  :.||..|
Worm  1720 EDSDRP----AEERQEDE------EREEGDEHEQDEQVEGEIEVVDRIEVQPVVEESERAEEPVW 1774

  Fly  1718 ---------------SDDQSDEFNFNEQQ----------------------------LERRSTN- 1738
                           .|:.||......::                            .|..|.:
Worm  1775 HAYEPASPSPRQPDFDDNSSDSQEGGAREPAFVIADVAHPLEVAQAQPANVPIVRPVAENPSPSI 1839

  Fly  1739 --SNARSDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFIDP------------MALRR------- 1782
              |.|.|..|.:....|:..|..|.:| ||| ||::..|:.            ::.||
Worm  1840 MASIAASSAARERALEALAERRGAAAS-RVP-GSSVPRIERFLPYRFSSRSSFLSNRREDSSNSQ 1902

  Fly  1783 ---------------STVPASTTVT-------TPSIEPHTMATTASN------------------ 1807
                           ||.||..:.|       ..|:.|.|..|::||
Worm  1903 GSTLSYAAGSTTGTGSTAPAPASATAGNNNSQVRSVPPPTTTTSSSNQESSPASNSSKKSNDNTD 1967

  Fly  1808 ----------LARAFGITIRQISELISILSYNVLNDIETSLKIQNDEA----IAVQAFVEKRLKA 1858
                      ||..|.:.:|...:::|.:...|:: :.|.   .:|.|    :..|......|:.
Worm  1968 QPSLETAREQLALTFSVLVRAGCDILSRMPRPVMS-VYTK---ADDNAKRSQLKAQRLFGDILQD 2028

  Fly  1859 TWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNS 1923
            |:.||..|.:.|||::.|.                  .....|...||...|....|
Worm  2029 TFRWMGRVFESTEAKINFN------------------ETYEKSLVRPASPGSEDKRG-------- 2067

  Fly  1924 RRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINNL 1988
            |:|...|..||:|..|.|.:|:|..:||..|..:|.|.||:.:::               ..|..
Worm  2068 RKDALHYIHSLLRLATDEAKDSLAHVDIEMLYPVALVADAYFHFL---------------SCNVE 2117

  Fly  1989 SPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRH--------------AFFARSESTLS 2039
            .|:        ||..|.::..|.|             |||              .||.|..| ||
Worm  2118 RPI--------ELKQLIDYYEDSQ-------------RRHFREKCEQTDNDLMIGFFMRPVS-LS 2160

  Fly  2040 LGCSAPEGF------------ELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGAT 2092
            ......:|.            .|.::...|:...|.:|...:|:::||.: |::..|....|...
Worm  2161 WPGHLHDGAWDTLSGRHHISKTLKIEEECPMLGGPKMLTMLTKQEDLFRD-PVIDETKRRTSSYL 2224

  Fly  2093 NDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQG 2157
            ||    .:.:||      .|.|.|        |.:....|                 |.|....
Worm  2225 ND----PVEEYT------YNLLDR--------PFEYRNPG-----------------VSLAMVP- 2253

  Fly  2158 SDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVI 2222
                        ::.|.|:..:..|.|.....
Worm  2254 ------------HRLKLEREFISITRDFYHLD--------------------------------- 2273

  Fly  2223 VLAGGSCLKTIDSDINNYS-ASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSW 2286
                    :|.|.::.:|| |.........:.|....| ..|:||:......:.|
Worm  2274 --------RTPDHEVKDYSTAVGKFPGYIGRLDDSISK-FKDNLLIHSCNRERLY---------- 2319

  Fly  2287 NFLLSRWKLTLDLFGRVFMD--------DVGMEHGSVLPELRGFPVKEMRFRRHMEKLR--NGQQ 2341
               .|:|..||:..|..|.|        ||..|:..:|..|..|..|:..|.:..||.|  :...
Worm  2320 ---FSKWFKTLNAIGNRFYDKMTEALGADVAFENSIMLRRLASFETKQRLFNKATEKYRTQHSNV 2381

  Fly  2342 RDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQ------PPITFNRVKVTFKDEPGEGSGVAR 2400
            :::|| .:.|...||...|..:|:..:..:...::      .|:...|::|.|.||||||:||.|
Worm  2382 KEIVL-DVRREPGSLFRDTMVQLHHLYAKRMMSVRSLESGHAPLAGTRLRVHFIDEPGEGTGVTR 2445

  Fly  2401 SFYTSIAEALL----------ASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQ 2455
            ||||:.||:.:          .:.|...::||....|..::.:..:..||......:.|.::.||
Worm  2446 SFYTAFAESCMMDVAPFTPETVAEKSSLIQSVLHPNNEYEHDMEITKTLRKARREQAIRLRTHLQ 2510

  Fly  2456 RRGSNSKILWRSARERKALNLDARPYTPPN--SSDNATPESLNDHLSVHLQQIG-------ERLY 2511
            |            .:...|||.|..:...|  ...|.|.:.|.|. |...|.:.       |...
Worm  2511 R------------LKTFPLNLAAPRFDIKNFTGEGNWTKKVLQDS-SAESQPVAPLNWGQHEGTL 2562

  Fly  2512 PKIHSI------NQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAI-------EIITFKQK 2563
            .|||::      ::....::.|::.::||...:..:::|:|:|..:.:.:       |:..:.:.
Worm  2563 RKIHTMTSGFLTDEKTIGRVMGIMCQLPTEVFVKAVNNDDTMRLHIQQILAELRAEGELDDYSRV 2627

  Fly  2564 SETSAQSSQPKKSPS-----VVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRL 2623
            ......:.||:....     |....|:|.    ||.......||.|:.|..:..|:.|:|.:||:
Worm  2628 FRGLQNAEQPRSDDEQWNVLVGTESPLDQ----LFEKAPYGEFYVPKIGNGAPMRLAAYRTVGRI 2688

  Fly  2624 IGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMEL 2688
            :|:||.|.::.||...||:..|||...|.:.||.|:||.|:.:.|.:.:          .:..||
Worm  2689 MGICLSQGDIFPLRFSRHIFSYILKLPICWLDLGFYDPVLFNNLRALFK----------AHPSEL 2743

  Fly  2689 CFVIDLMKEEGCGNR---ELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVL 2750
            .....::::...|..   .|.|.|.:|.|...|:.|||.:|.|..|:..:....||:::|:.||:
Worm  2744 DTDFSIVEQSADGKAVTVNLKPNGDEVLVNKDNVIEYVYKYAERVLVGKRIITFEAIREGILDVI 2808

  Fly  2751 PDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQ 2815
            |::.:..||.|||||::.|:..:::|.|...|.|.|||....:.|.:||:|||.::|.....|:|
Worm  2809 PESMLFGLTPEDLRLIICGIESVSISVLQENTGFLDESRASQETLNRFKQWFWQVIESFTQQEKQ 2873

  Fly  2816 DLVYFWTGSPALPASEEGFQPL-PSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAI 2879
            :||:||||||||||:  |..|. .||.:||.:|..||||||||||||:|:||||.:||:|:|:||
Worm  2874 ELVFFWTGSPALPAA--GKWPTSASVMLRPQEDVFLPTANTCISRLYVPVYSSKRVLRTKLLLAI 2936

  Fly  2880 KSKNFGFV 2887
            |:||||||
Worm  2937 KAKNFGFV 2944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409	34/45 (76%)
		ZnF_UBR1	1217..1284	CDD:197698	54/68 (79%)
		ASF1_hist_chap	1535..1733	CDD:304562	52/308 (17%)
		PolyA	2498..2561	CDD:197769	13/82 (16%)
		HECTc	2589..2885	CDD:238033	120/299 (40%)
		HECTc	2589..2884	CDD:214523	119/298 (40%)
ubr-5	NP_492389.1	E3_UbLigase_EDD	182..233	CDD:288409	38/50 (76%)
		ZnF_UBR1	1202..1271	CDD:197698	54/68 (79%)
		HECTc	2576..2942	CDD:238033	132/381 (35%)
		HECTc	2614..2941	CDD:214523	125/342 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I357
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	719	1.000	Inparanoid score	I329
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45699
OrthoDB	1	1.010	-	-		D13816at33208
OrthoFinder	1	1.000	-	-		FOG0007203
OrthoInspector	1	1.000	-	-		oto18095
orthoMCL	1	0.900	-	-		OOG6_106470
Panther	1	1.100	-	-	LDO	PTHR46276
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3204
SonicParanoid	1	1.000	-	-		X5312
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910