DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and herc-1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	676	Identity:	142/676 - (21%)
Similarity:	265/676 - (39%)	Gaps:	141/676 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  2277 QSNFSELPSWN--FLLS---RWKLTLDLFGR---VFMDDVGMEHGSVLPELRGFPVK-------- 2325
            :|.||.|.|.|  ||..   |:.:.. .|.|   :.||.| ||...:..|   :|:|
Worm   405 ESVFSSLASMNMSFLYKDERRYNVGF-CFERSHGIDMDQV-MEAFMLFDE---YPMKRQYMELIV 464

  Fly  2326 ---EMRFRRHMEKLRNGQ--QRDLVLCKLERNRESLIVQTFKELNTQF--------GNQSRRIQP 2377
               ::.|:...|.|:..:  :..|:|..|....|::.|||.|.::|.|        |:....::.
Worm   465 DSLKIAFQEWSENLKGIECLRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEK 529

  Fly  2378 PIT------FNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPN--------LESVQVGTNH 2428
            ..|      |.|:...||              |:| :|:|.:.|.|.        ::.:.: .|.
Worm   530 WWTQLSTRHFRRMVTVFK--------------TAI-KAMLKAKKGPRDCHKFILIMQKLSL-INK 578

  Fly  2429 SKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPE 2493
            :.:::|..:......  .:|.|...       ..:|..:.::.....||...:.|...:..|..|
Worm   579 TYHIIPLETFYIDEL--NTSVDLKL-------EYVLELTRQDPNKTELDYWTHFPFLLNGVAKGE 634

  Fly  2494 SLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLL---SVISSDETLRQ------ 2549
            .:  .:...|.|...|   :....|..|..    ::.|:|..:|.   ..|.|| |:.|
Worm   635 LI--FVEAWLMQTLRR---QSSLFNTAHGT----IIFELPHLELTVRREFIVSD-TMNQMAGLSE 689

  Fly  2550 -------KVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPV---------DDDNEPLFYSPGK 2598
                   |||.|         .|.:..:...:|...::|:..:         :|:...|.:..|.
Worm   690 SDLQKPLKVNIA---------GEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGL 745

  Fly  2599 RGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPAL 2663
            ...:..|:         .|..:|||:||.:..:.::|......:.||:|.......||....|:.
Worm   746 PSEFCDRE---------QFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSE 801

  Fly  2664 YESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTE 2728
            .:..:.::  :..::..|.:..:..|...:::.|  ....||:.||.:..||::|..||||.|..
Worm   802 GKGLKMLL--SYEEDDVEDVFGLNFCISFNILGE--THTTELLSGGTEKPVTNANRDEYVRLYVH 862

  Fly  2729 YRLI--KSQEKALEAL--KDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESS 2789
            :||.  .:.|.|.:||  :.|..:.|...::......:|:.::.|..:.:.:.......:..|.|
Worm   863 HRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYS 927

  Fly  2790 EGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPTAN 2854
            .....:..|.|.|:::.:.    ||:..:.|.|||..:|.|  |::.| ...|:|:....||.|:
Worm   928 SSHPTIQAFWKAFFALTDD----ERRKFLQFLTGSTRIPVS--GWEEL-HAAIQPSAPESLPVAH 985

  Fly  2855 TCISRLYIPLYSSKSILRSKMLMAIK 2880
            ||.:.|.:|..:....|..::.::|:
Worm   986 TCFNLLDLPNIADDVELLRRLRISIE 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	17/78 (22%)
		HECTc	2589..2885	CDD:238033	67/296 (23%)
		HECTc	2589..2884	CDD:214523	67/296 (23%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	81/375 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900