DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Magi1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_006505643.1	Gene:	Magi1 / 14924	MGIID:	1203522	Length:	1484	Species:	Mus musculus

Alignment Length:	1614	Identity:	299/1614 - (18%)
Similarity:	485/1614 - (30%)	Gaps:	618/1614 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1376 EPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTL---L 1437
            |.||.|.   ..||::...||   :||..|.||.....|..|...      |...:.|..|   |
Mouse    60 EGPKLAE---GELLLEVQGVR---VSGLPRYDVLGVIDSCKEAVT------FKAVRQGGRLNKDL 112

  Fly  1438 DKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEVVRRFVR--SVARVFVIFNLEKQP 1500
            ..|.:....|.:.||          |||.....|..:.|.....|..|  .|..|...|
Mouse   113 RHFLNQRFQKGSPDH----------ELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYSF------ 161

  Fly  1501 NPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLDVR 1565
                                       ::::|..::.:                   |.:.|:|.
Mouse   162 ---------------------------LTVKEFLDLEQ-------------------SGTLLEVG 180

  Fly  1566 NSDDLFSVDPLAPSNVESPSEQILVHDA------GNDQSA-----NFNIQQNYDVVAMETIRDAS 1619
            ..:..:...|..||  :..|.:::..||      |:.||.     ::|..||..:|
Mouse   181 TYEGNYYGTPKPPS--QPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV--------- 234

  Fly  1620 ESEEVINREANSHNQDDELIENQRNEDGMQDDESDNDFTFNDAETESDSDDNQSNQE-----VQR 1679
                        |.      ||:..||   ..|.::.||     .:|...|..:.||     |..
Mouse   235 ------------HP------ENEEEED---VPEMNSSFT-----ADSGDQDEHTLQEATLPPVNS 273

  Fly  1680 SVQAG------------ATVGSENDIG---------------VLFLEDESGDSS----------- 1706
            |:.|.            ..:.:|:::|               |.|::..:..:|
Mouse   274 SILAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQ 338

  Fly  1707 ------AQEEDGSEDGESDDQ-------------------SDEFNFNEQ------------QLER 1734
                  ..:|:|....|.|.:                   .|..|...|            |||:
Mouse   339 KPLEECEDDEEGVHTEELDSELELPAGWEKIEDPVYGVYYVDHINRKTQYENPVLEAKRKKQLEQ 403

  Fly  1735 RSTNSNARSDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPASTTVT-TPS-IE 1797
            :......:   .||..:|   :.|.|  ||..|...:....:|...|.:.:......| .|| ::
Mouse   404 QQQQQQPQ---PPQPEEW---TEDHA--SVVPPVAPSHPPSNPEPARETPLQGKPFFTRNPSELK 460

  Fly  1798 PHTMATTASNLARAFGITI---------RQISELI---------SILSYNVLNDIETSLKIQNDE 1844
            ...:.|.....:|.||.|:         .||..|:         .:.:.:|:..:..:..:.:..
Mouse   461 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTH 525

  Fly  1845 AIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLT-NYTDPNHPL---------HPLNLSAQA 1899
            |..|:.|....:.|:.|          .:|..|..|. :..|||..|         .|:.::.|.
Mouse   526 AQVVKIFQSIPIGASVD----------LELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 580

  Fly  1900 SSSQTPAPATSSSVNG-VNIM-----------GSNSRRDFFTYCLSLMRSHTSEHRDALPVLDIT 1952
            :..   :||:.||..| |:.|           .|||...:....:||..|..::     |.| ||
Mouse   581 TYD---SPASHSSKTGKVSSMKDARPSSPADVASNSSHGYPNDTVSLASSIATQ-----PEL-IT 636

  Fly  1953 ALRHIAYVLDAFVYYMRNDSGF-YDKQDTISG---RINNL--SPMTESYDTDDELANLEEFNADV 2011
                        |:.::...|| :...|:..|   |:..:  ||........|.:..:.:.|...
Mouse   637 ------------VHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQA 689

  Fly  2012 -------------------------------QMSASSMP---SGSQGTRRHAFFARSESTLSLGC 2042
                                           :.|..|.|   ..||.:.:|:.    .|..||..
Mouse   690 LTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSV----SSHRSLHT 750

  Fly  2043 SAP-EGFE-----LPLDMAMP-LAD-----KPHLLQPNSKRQELFANLPLLVTTNANNS------ 2089
            ::| .|.:     ||.|...| ..|     ||...:..::.:.::.|.|:..:..:..|
Mouse   751 ASPSHGIQVLPEYLPADAPAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERDR 815

  Fly  2090 --GATNDGDGGSIFDY---------TPTRLGFS--NSLKRNERVY--ETVPIDSSKTGDGNVTNK 2139
              .:||.|: ..|.||         ..|..||.  ...:..|.:|  ..||:.::.| ||.:.:.
Mouse   816 EINSTNFGE-CQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADT-DGRLRSG 878

  Fly  2140 AE-----GS----TDSNIYVQLKK---KQGSDDF-----------KSHKE----ADGNQSKYEKV 2177
            .|     |:    ....:.|||.:   |||..:.           |:..|    |..:.|..:..
Mouse   879 DELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKAENEVPSPASSHHSSNQPA 943

  Fly  2178 VLMETD----------DSLPSTSKSTEAL------------------------------------ 2196
            .|.|..          :::.|.|.||..:
Mouse   944 SLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSAVLQPYDVEIRRGENEGFGFVIVS 1008

  Fly  2197 MATRPEV---------IIAPNK----ASVSPA------TAARSVIVLAGGSCLKTIDSDINNY-- 2240
            ..:|||.         :..|:|    ...|||      .....::.:.|.|......|||.|.
Mouse  1009 SVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1073

  Fly  2241 -----------------SASNLSTAEQ----------AKCDTQYQKSTSDHLLLFPARGSQF--- 2275
                             :|:.|:.||:          ::..||..::|:.     |.:.|||
Mouse  1074 EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHAPSQQGTQETRTTTK-----PKQDSQFEFK 1133

  Fly  2276 -----YQSNFSEL------PSWNFLLSRWK-LTLDLFGRVFMDDVGMEH------GSVLPELRGF 2322
                 .:.:|..:      ..:.|.|...: ..:||:.....:|...|.      |..:.|:.|.
Mouse  1134 GPQAAQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGE 1198

  Fly  2323 PVKEMRFRRHMEKLRNGQQRDLVLCK------------LERNRESLIVQTFKELNTQFGNQSRRI 2375
            ..|.|:..|.:|.::||.:|..:..:            .:||..|...|...|:         |.
Mouse  1199 TTKNMKHSRAIELIKNGGRRVRLFLRRGDGSVPEYDPSSDRNGPSTGAQGVPEV---------RP 1254

  Fly  2376 QPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEA-LLASAKIP--NLE-SVQVGTNHSKYVVPFS 2436
            .||        ..:..|...|......:.|...| ..|.||.|  |.| |.|...:|
Mouse  1255 GPP--------DHRPHPALESSYPPELHKSSQHAEKRAHAKDPKGNREHSKQPNEHH-------- 1303

  Fly  2437 SILRSRTVSGSSRDQ-STLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLS 2500
                  |.:|:||.| |...|........||.|:..:         |..|.|...:||...:
Mouse  1304 ------TWNGTSRKQDSGACRPKDRPPDAWREAQPER---------TATNGSKRRSPEKRRE--- 1350

  Fly  2501 VHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETL--RQKVNEAIEII--TFK 2561
                  |.|                                |:|.||  |:|..:..||.  ..:
Mouse  1351 ------GTR--------------------------------SADNTLERREKHEKRREISPERKR 1377

  Fly  2562 QKSETSAQSSQPKKSPSVV--VVDPVDDDNEPLFYSPGKRGFYTPRQGFASFER 2613
            ::|.|..:.|.|.:....:  ::|...........||.:|...|.|:...|.||
Mouse  1378 ERSPTRRKDSSPSRRRRSLERLLDQRRSPERRRGGSPERRAKSTDRRRARSPER 1431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	44/288 (15%)
		PolyA	2498..2561	CDD:197769	10/66 (15%)
		HECTc	2589..2885	CDD:238033	8/25 (32%)
		HECTc	2589..2884	CDD:214523	8/25 (32%)
Magi1	XP_006505643.1	PDZ_signaling	15..100	CDD:238492	15/51 (29%)
		GuKc	122..293	CDD:214504	45/269 (17%)
		WW	302..331	CDD:366073	3/28 (11%)
		WW	362..393	CDD:197736	3/30 (10%)
		PDZ	462..548	CDD:214570	15/95 (16%)
		PDZ	633..716	CDD:214570	13/95 (14%)
		MAGI_u5	715..798	CDD:374709	18/86 (21%)
		PDZ_signaling	840..915	CDD:238492	18/75 (24%)
		PDZ_signaling	989..1084	CDD:238492	14/94 (15%)
		PDZ	1145..1227	CDD:214570	16/81 (20%)
		PRK12678	1203..>1452	CDD:237171	65/310 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900