DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Trip12

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_011236956.1	Gene:	Trip12 / 14897	MGIID:	1309481	Length:	2074	Species:	Mus musculus

Alignment Length:	2667	Identity:	480/2667 - (17%)
Similarity:	824/2667 - (30%)	Gaps:	948/2667 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   567 NTNSGVDKSQAAGNNLNAH------------------GITPDKDLPKSTAMP-----STGSSKNG 608
            |.|.|....::..|...|.                  |..|.:....:...|     :|.....|
Mouse     6 NNNPGGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKRKGYIPPESRKSNFKAPKVQSNTTSELSRG 70

  Fly   609 QSFSNSKESTDRIDMPPPPSPASSTCSD---TGSV---TSHKRTKRATTKE--DSNAPQEGRKDE 665
            .....|..|:..:.:|.|..|..:..|:   ||.|   .:.:..||:.:.:  .:|:|...:|..
Mouse    71 HLSKRSCSSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPR 135

  Fly   666 ELWEVKDVVFVE-DKVGPVGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEEGKE 729
            ....::.  |.| :|.....|...:|.:      ..:.:|.:.:.:.|.:..|..|.:|:.:.::
Mouse   136 AFQHIES--FSETNKPHSKSKKRHLDQE------QQLKSAQLPSTSKAHTRKSVAAGSSRNQKRK 192

  Fly   730 DDWQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVDSRGIHVIKKVLG 794
            .....|                           .|...|.::.||       :.|....||
Mouse   193 RTESSC---------------------------VKSGSGSESTGA-------EERSAKPIK---- 219

  Fly   795 KIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNGALYPLAKD 859
                 |.:......:..|...||.:|...::..:..:|      ..|||:..    ||.....||
Mouse   220 -----LASKSATSAKAGCSTITDSSSAASTSSSSSAIA------SASSTVPA----GARVKQGKD 269

  Fly   860 --------------------------CLGSIKDPQWFD----LPPVKSITMSTISLPAML----- 889
                                      ..||.|    ||    ..|..|:..:.:|||...
Mouse   270 QNKARRSRSASSPSPRRSSREKEQSKTGGSSK----FDWAARFSPKVSLPKTKLSLPGSSKSETS 330

  Fly   890 ----SGVNLKSKVCMTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTALVVEERCDGARN 950
                ||:..|    :.:|...|:|..        ::..|.|..|.|..:..|.        |:
Mouse   331 KPGPSGLQAK----LASLRKSTKKRS--------ESPPAELPSLRRSTRQKTT--------GS-- 373

  Fly   951 IFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTV----STSAYVSSIAFGASASSS 1011
                    ||.:|.:.|       |:.|:   |.:.||....:    |....|:|     ||:.:
Mouse   374 --------CASTSRRGS-------GLGKR---GAAEARRQEKMADPESNQETVNS-----SAART 415

  Fly  1012 NENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQA--EQSGSQPMATNNEDHAYIPWPA 1074
            :|....|..|||.||:...|:.....:....|.||    ||  |..|..|       |.:.|.
Mouse   416 DEAPQGAAASSSVAGAVGMTTSGESESDDSEMGRL----QALLEARGLPP-------HLFGPL-- 467

  Fly  1075 ETPAASNLSASSSQNVSDSIEDDISKIIPSSSQSSMLSNI----KLGSPTYTFDLAQRREHALTI 1135
             .|..|.|...:..:.:.|....:.:.:.:|.:|..|..:    :|        |....|..|..
Mouse   468 -GPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQL--------LVMGNEETLGG 523

  Fly  1136 LQQMCVSPALRPYLCHMLSTKDAQGQTPF-MLSVSCRAYEAGIILLNTILMLSEQDPQLKEAMIF 1199
            .....|.|||...|         |.:..| :::.:|||          :..:.|..|  :.:.:.
Mouse   524 FPVKSVVPALITLL---------QMEHNFDIMNHACRA----------LTYMMEALP--RSSAVV 567

  Fly  1200 PNGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKL- 1263
            .:..|.....|.||...|......|..:.:::.  ..|.....|.|.             ||.|
Mouse   568 VDAIPVFLEKLQVIQCIDVAEQALTALEMLSRR--HSKAILQAGGLA-------------DCLLY 617

  Fly  1264 --------KRTAPTAYCDCWEK-------------------------------CKCKALIAGNLT 1289
                    :|.|.....:|.:.                               |.|.|.:..|..
Mouse   618 LEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQ 682

  Fly  1290 KRFALLCKLVSCTDLVTKFNSKGESILLFL--IQTVGRQIVEQRQYRFSVRVRNVSTAATGATGN 1352
            ....|| :.|:..||:|..    :.:|:..  |.:.|..|:..|.  ||:...|..|.|
Mouse   683 HEENLL-QQVASKDLLTNV----QQLLVVTPPILSSGMFIMVVRM--FSLMCSNCPTLA------ 734

  Fly  1353 NSVISNRKTSAAEIDNDMPDH---------------DLEP--------------------PKFAR 1382
               :...|.|..:|...:  |               ||.|                    ||...
Mouse   735 ---VQLMKQSFTDIAETL--HFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGI 794

  Fly  1383 KALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVK 1447
            .|::.:|              ::|:..|..|:..:..:..|.      .|....:|    |.|::
Mouse   795 FAVDTML--------------KKGNAQNTDGAIWQWRDDRGL------WHPYNRID----SRIIE 835

  Fly  1448 CTSDHL--DTLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNP-------- 1502
            ..:..:  |.:.|:.:..:.....::..:..|:.      ..||.     ::::|||
Mouse   836 VAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDT------GTARA-----IQRKPNPLANSNTSG 889

  Fly  1503 ----EKRKSHSSCNKYVQSCVKVF-QTLHKISIEELCEVSEALIAP-VR---LGVVRPTAPFTMS 1558
                :|..:.:...|......|.| :||..:    |.||..:...| ||   |..:.....|..:
Mouse   890 YSELKKDDARAQLMKEDPELAKSFIKTLFGV----LYEVYSSSAGPAVRHKCLRAILRIIYFADA 950

  Fly  1559 SSNLDVRNSDDLFSVDPLAPSNVESPSEQILVHDAGNDQSANFNIQQNYDVVA--------METI 1615
            ....||..:   .:|.....|.:.|...:|:|   |..|.|...:|:..|:.:        |..:
Mouse   951 ELLKDVLKN---HAVSSHIASMLSSQDLKIVV---GALQMAEILMQKLPDIFSVYFRREGVMHQV 1009

  Fly  1616 RDASESEEVINREANSHNQDDELIENQRNEDGMQDDESDNDFTFNDAETESDSDDNQSNQEVQRS 1680
            :..:|||.::.                                 :..:..::...:..:.....|
Mouse  1010 KHLAESESLLT---------------------------------SPPKACTNGSGSLGSTTPASS 1041

  Fly  1681 VQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNARSDL 1745
            ..|.|...:..|:|...|:....||.    |.|..|...|.     ...::|.:|...   |...
Mouse  1042 GTATAATNASADLGSPSLQHSRDDSL----DLSPQGRLSDV-----LKRKRLPKRGPR---RPKY 1094

  Fly  1746 APQTMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPASTTVTTPSIEPHTMATTA--SNL 1808
            :|......:.::..:.::.:.|..|.:..::|....|.:..:::.    :|||   |.||  |.|
Mouse  1095 SPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSAQSNSN----NIEP---ARTAGVSGL 1152

  Fly  1809 ARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQ 1873
            |||..      .:.||    |....|:..:|.|      ...|||:...:      ..|||:...
Mouse  1153 ARAAS------KDTIS----NNREKIKGWIKEQ------AHKFVERYFSS------ENMDGSNPA 1195

  Fly  1874 LKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRSH 1938
            |.....|...|:      .|||.....:.                            ||..:||.
Mouse  1196 LNVLQRLCAATE------QLNLQVDGGAE----------------------------CLVEIRSI 1226

  Fly  1939 TSEHRDALPVLDITA--LRHIAYVLDAFVYYMRNDSGFYDKQDTISGR----------------- 1984
            .||.       |:::  ::|..:|....:|....     :::|.: ||
Mouse  1227 VSES-------DVSSFEIQHSGFVKQLLLYLTSK-----NEKDAV-GREIRLKRFLHVFFSSPLP 1278

  Fly  1985 ----INNLSPMTES------YDTDDELANLEEFNADVQMSASSMPSG---------SQGTRRHAF 2030
                :..:.|:..:      :..::.|:.:|:|...|.    ..|||         ::|::...|
Mouse  1279 GEEPVGRVEPVGHAPLLALVHKMNNCLSQMEQFPVKVH----DFPSGNGAGGSFSLNRGSQALKF 1339

  Fly  2031 FARSESTLSLGCSAP-----------EGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTT 2084
            |    :|..|.|...           :|..:.:|   |||    |:|...:         .||..
Mouse  1340 F----NTHQLKCQLQRHPDCANVKQWKGGPVKID---PLA----LVQAIER---------YLVVR 1384

  Fly  2085 NANNSGATNDGDGGSIFDYTPTRLG------FSNS---------------LKRNERVYETVPIDS 2128
            .....|...:.|..|..|.:...:.      |.||               |..|..||:.|...|
Mouse  1385 GIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFS 1449

  Fly  2129 SKTGDGNVTNKAEGSTDSNIYVQLKK-----KQGSDDFKSHKEADG----------------NQS 2172
            .:..|...:...|.:......:..|.     |...:|.:|.|:..|                |..
Mouse  1450 VQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESTKDCVGGKRGRAQTAPTKTSPRNAK 1514

  Fly  2173 KYEKVVLMETDDSLPSTSKSTEA-LMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSD 2236
            |:::   :..|...||.:...|. |:.|.||        :::....:..||:|     |:.:.:
Mouse  1515 KHDE---LWHDGVCPSVANPLEVYLIPTPPE--------NITFEDPSLDVILL-----LRVLHA- 1562

  Fly  2237 INNY---------------SASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSW 2286
            |:.|               ::..:::...||.:.|.|    |.|::..           ..:|:|
Mouse  1563 ISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQ----DPLVIMT-----------GNIPTW 1612

  Fly  2287 NFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRF-------RRHMEKL-------- 2336
                    ||              |.|...|....|..::|.|       .|.|::|
Mouse  1613 --------LT--------------ELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEIN 1655

  Fly  2337 RNGQQRDLVLCKLER-----NRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGS 2396
            ::..|...|..:|:|     |||.|:.|.  |...|....||.:        :::.:::|.|.|.
Mouse  1656 QSDSQDSRVAPRLDRKKRTVNREELLKQA--ESVMQDLGSSRAM--------LEIQYENEVGTGL 1710

  Fly  2397 GVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNS 2461
            |....||..:::                                            .|||.   .
Mouse  1711 GPTLEFYALVSQ--------------------------------------------ELQRA---D 1728

  Fly  2462 KILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQI-GERLYPKIHSINQTHAPKI 2525
            ..|||.  |...|       :.|..|...|.         ::|.: |....|...:....|..|:
Mouse  1729 LCLWRG--EEVTL-------SNPKGSQEGTK---------YIQNLQGLFALPFGRTAKPAHIAKV 1775

  Fly  2526 TGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNE 2590
                                               |.|
Mouse  1776 -----------------------------------KMK--------------------------- 1778

  Fly  2591 PLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRK--IKF 2653
                                      ||.:|:|:...::...|:.|.|.....|::|.::  :..
Mouse  1779 --------------------------FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTS 1817

  Fly  2654 HDLAFFDPALYES---FRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG-------------- 2701
            |||...||.:..|   ...|::..:..|.:::..:..|.:.::.:...||.
Mouse  1818 HDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFP 1882

  Fly  2702 NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLL 2766
            |.||..||:|:.||..|:.||:|....:.|.:...:..::.:||...|.|...:.....|:|..|
Mouse  1883 NIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLCHLQYFYPEELDQL 1947

  Fly  2767 LNG--VGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPA 2829
            |.|  ....:..||:.... .|.......:.:||   .:.|:...:..:::..:.|.||||.||.
Mouse  1948 LCGSKADTWDAKTLMECCR-PDHGYTHDSRAVKF---LFEILSSFDNEQQRLFLQFVTGSPRLPV 2008

  Fly  2830 SEEGFQPL-PSVTI---------RPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNF 2884
            .  ||:.| |.:||         .|  |..||:..||::.|.:|.|||..|:|.|:|:|.:....
Mouse  2009 G--GFRSLNPPLTIVRKTFESTENP--DDFLPSVMTCVNYLKLPDYSSIDIMRDKLLIAAREGQQ 2069

  Fly  2885 GF 2886
            .|
Mouse  2070 SF 2071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698	14/106 (13%)
		ASF1_hist_chap	1535..1733	CDD:304562	35/209 (17%)
		PolyA	2498..2561	CDD:197769	5/63 (8%)
		HECTc	2589..2885	CDD:238033	77/326 (24%)
		HECTc	2589..2884	CDD:214523	77/325 (24%)
Trip12	XP_011236956.1	SRP1	489..>714	CDD:227396	46/273 (17%)
		WWE	814..876	CDD:397111	10/82 (12%)
		HECTc	1672..2072	CDD:238033	111/571 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900