DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Gas7

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_006532265.1	Gene:	Gas7 / 14457	MGIID:	1202388	Length:	476	Species:	Mus musculus

Alignment Length:	337	Identity:	65/337 - (19%)
Similarity:	115/337 - (34%)	Gaps:	93/337 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VVIGPAHIGVLLEDGKAFRVSFSINSEKLDLTKSDAKCSTSGGSGTAS---------ASKAPSSS 105
            |::.|.....|...|:.:.|:.:.|....:...|....|.|.|...:|         ||..|  :
Mouse    77 VILPPGWHSYLSPQGRRYYVNTTTNETTWERPSSSPGISASPGPHRSSLPTTVNGYHASGTP--A 139

  Fly   106 RPMARSRARLLRATGRSNSTGQGS----GSRSTGVIIGGSTSSRPLVTVP--------------- 151
            .|...:...|.::||.|.:.|..|    .|:...:.|...|...| .|:|
Mouse   140 HPPETAHMSLRKSTGDSQNLGSSSPGRKQSKENTITINCVTFPHP-DTMPEQQLLKPTEWSYCDY 203

  Fly   152 -----------ATYVPEELISQAEVVLQGKSRNLIIRELQRTNLDV---------NLAVNNLLSR 196
                       .|....||:.|.:  |:||.....:.|..|..:.:         .|:.|:|.::
Mouse   204 FWADKKDPQGNGTVAGFELLLQKQ--LKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQ 266

  Fly   197 DD---------------EEAE---DTEEGADNYVPEDLISLLDNGFSGDNNSVIIDPSDGLFSEE 243
            ::               :|||   .......:.|.:.|::..:| |..|........:|  ..::
Mouse   267 EEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFREN-FKKDMKKCDHHIAD--LRKQ 328

  Fly   244 IFSNYSSI---RNLLFDRIRS--------ERSNANANAADSNQSTTRSTSSGTALTGNSGLSAQI 297
            :.|.|:|:   |..|.:|.:.        |...:|....|..::..:||.:|..|        ..
Mouse   329 LASRYASVEKARKALTERQKDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDL--------MR 385

  Fly   298 SVNADREAFSRW 309
            .|:...:|.|:|
Mouse   386 CVDLYNQAQSKW 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409	13/80 (16%)
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
Gas7	XP_006532265.1	SH3_GAS7	5..57	CDD:212763
		WW_FCH_linker	109..201	CDD:374680	21/94 (22%)
		F-BAR_GAS7	214..446	CDD:153333	38/197 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900