DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	1488	Identity:	264/1488 - (17%)
Similarity:	445/1488 - (29%)	Gaps:	469/1488 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1405 RGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASV 1469
            |.|:|.   ...|....||.:.||.....:|   .|.|.:..:.:.::.:.:|    :|..|..:
Human    53 RSDLPR---GWEEGFTEEGASYFIDHNQQTT---AFRHPVTGQFSPENSEFIL----QEEPNPHM 107

  Fly  1470 SNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHS---SCNKYVQSC-------VKVFQT 1524
            |.:.:....  ...|...:.......||.:|.|:..||.|   |..|..|:.       |.|...
Human   108 SKQDRNQRP--SSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGW 170

  Fly  1525 LHK-------------ISIEELC------EVSEALIAPVRLG--VVRPTAP-------FTMSSSN 1561
            |||             ..:.:.|      ...||::..:.|.  |:.|.||       ::..:.:
Human   171 LHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVH 235

  Fly  1562 LDVR----NSDDLFSVDPLAPSNVESPSEQILVHDAGNDQSAN---------------FNIQQNY 1607
            ..:|    ||.       .|.|..|....:.....|...:..|               .:::::.
Human   236 TGMRALIYNSS-------TAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDM 293

  Fly  1608 DVVAMETIRDASESEEV--INREANSHNQD------DELIENQRNE-------------DGMQD- 1650
            :.|..:.:..|:.:|..  ..|....|.:|      |:::..:|.|             :|.:|
Human   294 EKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDR 358

  Fly  1651 -------DESDNDFTFNDAETESDSDDNQSNQ-EVQRSVQAGATVGSENDIGVL----------- 1696
                   ..::.|..|.|..|.......|..: |....:.|....|.:|..|..
Human   359 SKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTNPE 423

  Fly  1697 --------------FLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNARSDLAP 1747
                          :...:.|||.:...|.:...:...||..|..|.|.|.:.:.:.:..|...|
Human   424 KHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPP 488

  Fly  1748 ---------------------------------QTMQWAIRSR------------------DTAR 1761
                                             |..:|..|.:                  |..|
Human   489 RNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICLGSPEFTDQGR 553

  Fly  1762 S--------SVRV--------PTGSNMVFIDPMALRRSTVPAS-TTVTTPSIEPHTMATTASNLA 1809
            |        |:.|        |.|...|| .|   ||...||. .||..|........:...:..
Human   554 SRSMLEVPRSISVPPSPSDIPPPGPPRVF-PP---RRPHTPAERVTVKPPDQRRSVDISLGDSPR 614

  Fly  1810 RAFGITIRQISEL-------ISILSYNV------------LNDIETSLKIQNDEAIAVQAF-VEK 1854
            ||.|..::..|.:       :..:::.|            |:.:.|.|:....:..:|:.| :.:
Human   615 RARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLRRHQAKLASVRNFAISQ 679

  Fly  1855 RLKATWDWMFTVMDGTEAQLKFG-AYLTNYTDPNHPLHPLNLSAQASSSQTPAPATS-------- 1910
            .|:....:.....|.|..|||.. .||......|.||..:.......|::...|..|
Human   680 LLQHQLTFPTCQADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPRRSMTGRDLLK 744

  Fly  1911 -SSVNGVNIMGSNSRRDFFTYC------------LSLMRSHTSEHRDALPVL--DITALRHIAYV 1960
             .|:..|.|..|::......:|            :..::.:..:....|.||  .:...|.....
Human   745 DRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQH 809

  Fly  1961 LDAFVYYMRNDSGFYDKQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGT 2025
            |:...|..:     ..::|.:..|.......||..:..:|...||.   ||:....::    |..
Human   810 LEKIAYQQK-----LLQEDLVHIRAELSRESTEMENAWNEYLKLEN---DVEQLKQTL----QEQ 862

  Fly  2026 RRHAFFARSESTL----------SLGCSA-PEGFELPLDMAMPLADKPHLLQPNSKRQELFANLP 2079
            .|.|||.:.:|.:          :.|.|| .|.|.:.::         .:..|..|...||.:.|
Human   863 HRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVE---------SVKNPERKTVPLFPHPP 918

  Fly  2080 LLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGST 2144
            :...:.:.:..........|     |.|......|....:.|  ||..........||:..:..|
Human   919 VPSLSTSESKPPPQPSPPTS-----PVRTPLEVRLFPQLQTY--VPYRPHPPQLRKVTSPLQSPT 976

  Fly  2145 DSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMA--TRPEVIIAP 2207
            .:...||                               :|..|......|....  ..|.|...|
Human   977 KAKPKVQ-------------------------------EDEAPPRPPLPELYSPEDQPPAVPPLP 1010

  Fly  2208 NKASVSPATAARSVIVLAG--------GSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDH 2264
            .:|::...|:.|.:...:.        |.|   ::.|......|.:|..|.|         |...
Human  1011 REATIIRHTSVRGLKRQSDERKRDRELGQC---VNGDSRVELRSYVSEPELA---------TLSG 1063

  Fly  2265 LLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPEL---RG----- 2321
            .:..|:.|....:|.:..||......|..:|              .:..::.|.:   ||
Human  1064 DMAQPSLGLVGPESRYQTLPGRGLSGSTSRL--------------QQSSTIAPYVTLRRGLNAES 1114

  Fly  2322 ----FPVKEMRFRRHMEKLRNG-QQRDLV-----LCKLERNRESLIVQTFKELNTQFGNQSRRIQ 2376
                ||    |.:..:|:|.:| .||..:     |.:::|::::|:    :|.....|.
Human  1115 SKATFP----RPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALV----RERKRTLGQ------ 1165

  Fly  2377 PPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRS 2441
                            ||.:|:..|.|        .|..:|.    .:|:  .|....|...|..
Human  1166 ----------------GERTGLPSSRY--------LSRPLPG----DLGS--WKREQDFDLQLLE 1200

  Fly  2442 RTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARP--YTPPNSSDNATPESLNDHLSVHLQ 2504
            |.|.|..:|:   :..|      |...:......||..|  |....|.:.:.||.::
Human  1201 RVVQGEKKDK---EENG------WLKVQAMPVTELDLEPQDYDLDISRELSKPEKVS-------- 1248

  Fly  2505 QIGERLY-------PKIHSINQTH--APKITGMLLEIPTPQLLSVISSDET------LRQKVNEA 2554
             |.||..       |.:..:...:  |.||..:|.......|......|:.      |:.:..|.
Human  1249 -IPERYVELDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSGQDQNSVADLDLQLQEQER 1312

  Fly  2555 IEIITFKQKSETSAQSSQ---------PKKSP-SVVVVDPVDDDNEPLFYSPGKRGFY 2602
            |..|::...||.|.:|.|         |.|.| |...|.|         |.|...|.:
Human  1313 IINISYALASEASQRSKQVAAQQLALLPPKGPLSSRTVPP---------YPPFTNGLH 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	45/280 (16%)
		PolyA	2498..2561	CDD:197769	14/77 (18%)
		HECTc	2589..2885	CDD:238033	3/14 (21%)
		HECTc	2589..2884	CDD:214523	3/14 (21%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827	8/34 (24%)
		PH_PEPP1_2_3	159..281	CDD:270068	21/128 (16%)
		NESP55	<299..460	CDD:115071	24/160 (15%)
		DUF1640	779..905	CDD:311647	26/146 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900