DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and Ube3b

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	768	Identity:	160/768 - (20%)
Similarity:	289/768 - (37%)	Gaps:	205/768 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2230 LKTIDSDINNYSASNLSTAEQAKCDTQ-----------------YQKSTSDHLLLFPARGSQ--- 2274
            ::.:.|||  .|...|..||.|....|                 :|||.|...:|.|..|.:
Mouse   394 IRILFSDI--LSRKLLEHAEPAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDS 456

  Fly  2275 -----------FYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEM- 2327
                       .||::.:       .|::.:|.: |.|..::||       :||:|..| :.|:
Mouse   457 AEVRKVCNICVLYQTSLT-------TLTQIRLQI-LTGLTYLDD-------LLPKLWAF-ICELG 505

  Fly  2328 ---RFRRHMEKLRN--GQQRDL-----VLCKLERNRESLI--VQTFKELNTQFGNQSRRIQPPIT 2380
               ..:..:|.|.|  |:.:.|     :.|...|:..:::  ::.::|
Mouse   506 PHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEE----------------- 553

  Fly  2381 FNRVKVTFK-DEPGEGSGVARSF-YTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRT 2443
                :::|| :|....|....|| :..|.:.::.:||...||..|  :.|...:|.:....|.|.
Mouse   554 ----QISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQ--SVHGWLMVLYERDCRRRF 612

  Fly  2444 VSGSSRDQSTLQRRGSNSKILWRSA---RERKALNLDARPYTPPN-------------------- 2485
            .     .:....||.....:|::..   |.|..|.|...|:..|:
Mouse   613 A-----PEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGL 672

  Fly  2486 -SSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSV----ISSDE 2545
             .:.:|:|..  .|:::...::.|..|.::..::| ||.|   .::.:.....|.|    |..|.
Mouse   673 VETSSASPHV--THITIRRSRMLEDGYEQLRQLSQ-HAMK---GVIRVKFVNDLGVDEAGIDQDG 731

  Fly  2546 TLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFAS 2610
            ..::.:.|.|:.:.                .|::.:......| |.|:.||         ..:..
Mouse   732 VFKEFLEEIIKRVF----------------DPALNLFKTTSGD-ERLYPSP---------TSYIH 770

  Fly  2611 FERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFD-----PALYESFRQI 2670
            ...:..|..:|:::|..:.:..::.:......|..:||.    |...|:.     |:|...|.:.
Mouse   771 ENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGH----HHSVFYSSVDELPSLDSEFYKN 831

  Fly  2671 IQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRL---I 2732
            :.:.:..:|:.....:.|.:..|:|.:..|  .||:|||:.:.||..|...|:.....:|:   |
Mouse   832 LTSIKRYDGDIADLGLTLSYDEDVMGQLVC--HELVPGGKTIPVTDENKISYIHLMAHFRMHTQI 894

  Fly  2733 KSQEKALEALKDGVFDVL-PDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLL 2796
            |:|..||.:   |...:: |:...:..|.|..||:.....:|::..|..:|.:.. ...|..:::
Mouse   895 KNQTAALIS---GFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYG-GFHGSHRVI 955

  Fly  2797 KFKKWFWSIV-EKMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVTIR---PADD--------- 2847
               .|.|.|: ......||...:.|.|.....|..  ||..| |..:||   .:||
Mouse   956 ---IWLWDILASDFTPEERAMFLKFVTSCSRPPLL--GFAYLKPPFSIRCVEVSDDQDTGDTLGS 1015

  Fly  2848 --------------SHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
                          ..|||::||.:.|.:|.||.||:||.|:..|| |.|.||
Mouse  1016 VLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI-SMNTGF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	13/66 (20%)
		HECTc	2589..2885	CDD:238033	79/332 (24%)
		HECTc	2589..2884	CDD:214523	78/331 (24%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	96/430 (22%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	88/402 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900