DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Ubr5

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_038936091.1	Gene:	Ubr5 / 117060	RGDID:	621236	Length:	2798	Species:	Rattus norvegicus

Alignment Length:	3099	Identity:	1233/3099 - (39%)
Similarity:	1748/3099 - (56%)	Gaps:	513/3099 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSMQFVLQPLPGSDDQFIERIREVSDKVNRFGYGSH---RIFEQLKIPVKEVVIGPAHIGVLLE 62
            |.|:.||:.||||::||..:|:||||:|:|::...||   .:.||..|  |:.|:||.|...|||
  Rat     1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATI--KQCVVGPNHAAFLLE 63

  Fly    63 DGKAFRVSFSINSEKLDLTKSD----AKCSTSGGSGTAS----ASKAP---SSSRPMARSRARLL 116
            ||:..|:.||:..::|:|.|.|    :|.::|.|:|..|    .|.:|   |.|..:.|.....|
  Rat    64 DGRICRIGFSVQPDRLELGKPDNNDGSKLNSSSGTGRTSRPGRTSDSPWFLSGSETLGRLAGNTL 128

  Fly   117 RATGRSNSTGQGSGS------------RSTGVII------GGSTSSRPLVTVPATYVPEELISQA 163
            .:...|...|.|.||            |.|.||.      .|...|:|...:||:.:||||||||
  Rat   129 GSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQA 193

  Fly   164 EVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEEAEDTEEGA-DNYVP-EDLISLLDNGFSG 226
            :||||||||::|||||||||||||||||||||||||:.:|.::.| ::|:| |||:||||.....
  Rat   194 QVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHS 258

  Fly   227 DNNSVIIDPSDGLFSEEI-FSNYSSIRNLLFDRIRSERSNANANAADSNQSTTRSTSSGTALTGN 290
            .:.||||| :|.:|||:| :..|.|.|.....|:.|.|........||
  Rat   259 AHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDS----------------- 305

  Fly   291 SGLSAQISVNADREAFSRWRDRQYYGPRRWISKDDYTWEKDADSKKKEP------SPMLSPIWIS 349
                   .:..:||:..|.|:      |||:....:..|:.:.||:.||      :|:.||:.:.
  Rat   306 -------ELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPNPDKKNTPVQSPVSLG 357

  Fly   350 EELQPWPEKSSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYK-SETENVYHPKTVSLNIV-E 412
            |:||.||:|...:|..|||||||.:|:|..|:||||:|:::|||: ::..:::||:...|.:. |
  Rat   358 EDLQWWPDKDGTKFTCIGALYSELVAVSSKGELYQWKWTESEPYRNAQNPSLHHPRATFLGLTNE 422

  Fly   413 RVELISANFIRCSVVTETNRVATWMDEQLGYIGAKLEHSCCAFNEFISDSITKIYVCSLYTVVKT 477
            ::.|:|||.||.:|.||.|:||||:||.|..:.:||||:...::|...:.|..::.|:|||..:.
  Rat   423 KIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQL 487

  Fly   478 ESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVA----TDINVGAQVIMKKCPMYQSGSIGFTC 538
            | ||:|||||:||.||:.:.:|.|.|.|||.....    .:|.||.||.::..|:|.:|::.|:.
  Rat   488 E-NNLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSI 551

  Fly   539 SNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTG 603
            |.|:||||.|:.|||...|.||.::.:..:...::|
  Rat   552 SAGIPKVGVLMESVWNMNDSCRFQLRSPESLKSMEK----------------------------- 587

  Fly   604 SSKNGQSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTS-----HKRTKRATTKEDSNAPQEGRK 663
            :||..::...||:...:.:|.|||||| |||||..|:.|     :|| :|:|.     ||:|..|
  Rat   588 ASKTIETKPESKQEPVKTEMGPPPSPA-STCSDASSIASSASMPYKR-RRSTP-----APKEEEK 645

  Fly   664 -DEELWEVKDVVFVED-KVGPVGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEE 726
             :||.|.:::|||||| |..||||||||||.:|||:||            .|||.:|..::|
  Rat   646 VNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFP------------GTSSNTNCQNSS--- 695

  Fly   727 GKEDD----WQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVDSRGIH 787
            |.:.|    .|.|||||.:::|:.:|..:.:.||..|:.|||:.:   ....:||.:.|||:|:|
  Rat   696 GPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCI---PEKTEILAVNVDSKGVH 757

  Fly   788 VIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNGA 852
            .:.|....:.|.:::|...|.||...|||...:|:|....::.:.    .:|..|.|:||||||.
  Rat   758 AVLKTGNWVRYCIFDLATGKAEQENNFPTSSVAFLGQNERSVAIF----TAGQESPIILRDGNGT 818

  Fly   853 LYPLAKDCLGSIKDPQWFDLPPVKSITM---STISLPAMLSGVNLKSKVCMTALLFDTQKLMPHI 914
            :||:||||:|.|:||.|.||||:.|:.|   |.|:|||   ...:|.|..:..:..:.|.||.||
  Rat   819 IYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPA---NSTIKKKAAIIIMAVEKQTLMQHI 880

  Fly   915 LRCDVKNSFAALGRLEREDQADTALVVEE-----------RCDGARNIFHACVIMCAPSSNKDSP 968
            ||||.:.....|..||:      |:|:|:           ||||.|||.||||.:|.|:|||::.
  Rat   881 LRCDYEACRQYLVNLEQ------AVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETK 939

  Fly   969 PDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTSR 1033
            .:..:...|:.:.           ....:.|.:||...|..|||.       ..:.|||:||.|
  Rat   940 EEEEAERSERNTF-----------AERLSAVEAIANAISVVSSNG-------PGNRAGSSSSRS- 985

  Fly  1034 DNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDH-----------AYIPWPAE-----------T 1076
               ..||:||.|   |.:|...|......::.||           :::|.|..           .
  Rat   986 ---LRLREMMRR---SLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPSMDPDGDIDFILA 1044

  Fly  1077 PAASNLSASSS---QNVSDSIEDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQ 1138
            ||..:|:.:::   |..|.|       .||..|....:...|           .|:.:|..||:.
  Rat  1045 PAVGSLTTAATGGGQGPSTS-------TIPGPSTEPSVVESK-----------DRKANAHFILKL 1091

  Fly  1139 MCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILML-------SEQDPQLKEA 1196
            :|.|..|:|||..:||.|||:|.||||.:||.|||.|.|.:|.|...:       ||::..:...
  Rat  1092 LCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEVSGSEKEEDVFMG 1156

  Fly  1197 MIFPNGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDC 1261
            |:.|:|:..|.|||:|:|.|||||||||||:||||:||||:||||..||||||||||||||||||
  Rat  1157 MVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDC 1221

  Fly  1262 KLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQ 1326
            |||||:||||||||||||||.||||..:.|..||.:|::.|:|||..||:||.:||||:|||.||
  Rat  1222 KLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQ 1286

  Fly  1327 IVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLID 1391
            .||..||| ..|:|.              ..||||::.: |:||||||||||:||:.||||:|.|
  Rat  1287 TVEHCQYR-PPRIRE--------------DRNRKTASPD-DSDMPDHDLEPPRFAQLALERVLQD 1335

  Fly  1392 WNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSD--HLD 1454
            |||:|||||.|::....|..|.|...:...|. .:::..|.|:..||.|||.||||||:|  .||
  Rat  1336 WNALRSMIMFGSQENKDPLSASSRIGHLLPEE-QVYLNQQSGTIRLDCFTHCLIVKCTADILLLD 1399

  Fly  1455 TLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQSCV 1519
            |||.|||:||||.....|.:||..|..||:|||||||||.::|.   ...:|.::...:.:..|.
  Rat  1400 TLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEM---ASSKKKNNFIPQPIGKCK 1461

  Fly  1520 KVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLD-VRNSDDLFSVDPLAPSNVES 1583
            :|||.|...::||||.|:|:||.|||:|:.|||||||::|:::| ::.|::||||:||.|    .
  Rat  1462 RVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPP----R 1522

  Fly  1584 PSEQILVHDAGNDQSANFNIQQNYDVVAMETIRDASESEEVINREANSHNQDD---------ELI 1639
            ||         :|||::.:..|:..::.....|..|:|:.|..||   ..|||         |::
  Rat  1523 PS---------SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRE---EEQDDIVSADVEEVEVV 1575

  Fly  1640 ENQRNEDGMQD----------------DESDNDFTFND------AETESDSDDNQSNQE---VQR 1679
            |....|:...|                ||.|.|.:..:      |||||||:.|.|||:   .:|
  Rat  1576 EGVAGEEDHHDEQEEHGEENAEAEGHHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRR 1640

  Fly  1680 SVQAGATVGSE---NDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNA 1741
            ||...||.|||   :.:...|.||:|..:.:.:.| |...:|||...|....::.|||.:.:|:|
  Rat  1641 SVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSD-SSSSQSDDIEQETFMLDEPLERTTNSSHA 1704

  Fly  1742 R-SDLAPQTMQWAI------RSRDTARSSVRVPTGSN--MVFIDPMALRRS-TVPASTTVTTPSI 1796
            . :..||::||||:      |:..||.||...|..|:  :::|||..|||| |:..|......::
  Rat  1705 NGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAAL 1769

  Fly  1797 EPHTMA---TTASNLARAFGITIRQISELISIL-SYN--VLNDIETSLKIQNDEAIAVQAFVEKR 1855
            |....:   |:||:||||:.|.|||||:|:.:: .||  |.:.|..::|:...:|:.:|.:||::
  Rat  1770 EASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEK 1834

  Fly  1856 LKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGV---- 1916
            |..||:||.::||.|||||::|:.|.:..||.||.|||:.|..::..:.......:|:..:
  Rat  1835 LIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRR 1899

  Fly  1917 --NIMGS-----NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDS 1972
              .::.:     ::|.||..|.|||||||..||.|.|||||:.:|:|:|||..|.:|:::  |..
  Rat  1900 RATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQ 1964

  Fly  1973 GFYDKQDTISGRINNLSPM-----TESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFA 2032
            ...|.......|...|..:     ...::.||:.:.....|   .....|:|  ::..:.|.||.
  Rat  1965 TTLDTPQLERKRTRELLELGIDNEDSEHENDDDTSQSATLN---DKDDESLP--AETGQNHPFFR 2024

  Fly  2033 RSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG-----AT 2092
            ||:|...|||..|..||:||..|:||||:|||||||:::::||......:.:::..||     .|
  Rat  2025 RSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 2089

  Fly  2093 NDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQG 2157
            .|   .:..:..||::.::.:||                   ||.|           :|.::|:.
  Rat  2090 MD---RNCLEVLPTKMSYAANLK-------------------NVMN-----------MQNRQKKA 2121

  Fly  2158 SDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVI 2222
            .:|              :.::..|.|.|.|..|....|              |.:..:..|...:
  Rat  2122 GED--------------QSMLAEEADSSKPGPSAHDVA--------------AQLKSSLLAEIGL 2158

  Fly  2223 VLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWN 2287
            ..:.|..|                |:.:.:|                        |....:.|.:
  Rat  2159 TESEGPPL----------------TSFRPQC------------------------SFMGMVISHD 2183

  Fly  2288 FLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERN 2352
            .||.||:|:|:|||||||:|||.|.||:|.||.||.|||.:|||.||||||.|.|||.| :::|:
  Rat  2184 MLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSL-EVDRD 2247

  Fly  2353 RESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIP 2417
            |:.||.||.::||..||.  |....|:..:||||||||||||||||||||||:||:|.|::.|:|
  Rat  2248 RDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLP 2310

  Fly  2418 NLESVQ---VGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARE---RKALNL 2476
            ||:.:|   .||:.|     ....||:|......|::....||.|..:...|..|:   |:.|::
  Rat  2311 NLDCIQNANKGTHTS-----LMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSI 2370

  Fly  2477 DARPYTPP---NSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLL 2538
            |.||:.|.   |.||:..|      |..|.|.:||||||::.::....|.||||||||:...|||
  Rat  2371 DTRPFRPASEGNPSDDPDP------LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLL 2429

  Fly  2539 SVISSDETLRQKVNEAIEIITFKQKS------------ETSAQSSQPKK----SPSVVVVDPVD- 2586
            .:::|:::||.:|.||:|:|....:.            ::|.:..:.:|    |.|||.:|..|
  Rat  2430 LLLASEDSLRARVEEAMELIVAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDT 2494

  Fly  2587 ---DDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILG 2648
               |||.||||.||||||||||.|..:..|:|.||||||::|||||||||.|:.|.|||:|.:||
  Rat  2495 DDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG 2559

  Fly  2649 RKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVA 2713
            ||:.:||.|||||.:|||.||:|..:|:.:.:...:.|:|.|.:||.||||.|..||||.|.::.
  Rat  2560 RKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIP 2624

  Fly  2714 VTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTL 2778
            ||..|::||||:|.|:|::...|:.|.|::.|:.||||.||:.:|||||.|||:||.|::||..|
  Rat  2625 VTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 2689

  Fly  2779 ISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIR 2843
            ||:|:|||||.|..:|||:||:|||||||:|::.||||||||||.||:||||||||||:||:|||
  Rat  2690 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIR 2754

  Fly  2844 PADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887
            |.||.|||||||||||||:||||||.||:.|:|:|||:||||||
  Rat  2755 PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409	38/45 (84%)
		ZnF_UBR1	1217..1284	CDD:197698	59/66 (89%)
		ASF1_hist_chap	1535..1733	CDD:304562	77/235 (33%)
		PolyA	2498..2561	CDD:197769	29/62 (47%)
		HECTc	2589..2885	CDD:238033	186/295 (63%)
		HECTc	2589..2884	CDD:214523	185/294 (63%)
Ubr5	XP_038936091.1	CUE_UBR5	184..230	CDD:270606	40/45 (89%)
		ZnF_UBR1	1177..1244	CDD:197698	59/66 (89%)
		PolyA	2389..2452	CDD:197769	30/68 (44%)
		HECTc	2500..2795	CDD:214523	185/294 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353029
Domainoid	1	1.000	1351	1.000	Domainoid score	I7
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1897	1.000	Inparanoid score	I50
OMA	1	1.010	-	-		QHG45699
OrthoDB	1	1.010	-	-		D13816at33208
OrthoFinder	1	1.000	-	-		FOG0007203
OrthoInspector	1	1.000	-	-		oto97898
orthoMCL	1	0.900	-	-		OOG6_106470
Panther	1	1.100	-	-	LDO	PTHR46276
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5312
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910