Protein Alignment hyd and WWP1

DIOPT Version :9

• Sequence 1: NP_001287262.1
• Gene: hyd / 41181
• FlyBaseID: FBgn0002431
• Length: 2887
• Species: Drosophila melanogaster
• Sequence 2: NP_008944.1
• Gene: WWP1 / 11059
• HGNCID: 17004
• Length: 922
• Species: Homo sapiens
• Alignment Length: 1116
• Identity: 212/1116 - (18%)
• Similarity: 380/1116 - (34%)
• Gaps: 308/1116 - (27%)

  Fly  1855 RLKATWDWMFT------VMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSV 1913
            :||...:|..|      |:||                      .:..:|::|||..|......:|
Human    28 KLKRKKNWFGTAIYTEVVVDG----------------------EITKTAKSSSSSNPKWDEQLTV 70

  Fly  1914 NGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDAL---PVLDI-TAL----RHIAYVLDAFVYYMRN 1970
            |    :...:..:|..:      ||.:...|||   ..:|: .||    |.:..|.:.....:.|
Human    71 N----VTPQTTLEFQVW------SHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLEN 125

  Fly  1971 DSGFYD-------------KQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGS 2022
            .:|...             :|:.|:.  .:.||..|..:..|.|.  |......:.:|.....|:
Human   126 KNGIAQTGELTVVLDGLVIEQENITN--CSSSPTIEIQENGDALH--ENGEPSARTTARLAVEGT 186

  Fly  2023 QGTRRHAFFARSESTL--SLGCS-APEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTT 2084
            .|...|.    ..|||  :..|| ...|...|...:. :|.:|    .|:...:..|:.|...|.
Human   187 NGIDNHV----PTSTLVQNSCCSYVVNGDNTPSSPSQ-VAARP----KNTPAPKPLASEPADDTV 242

  Fly  2085 NANNSGATNDGDGGSIFDYTPTRLGFSNSLKRN--ERVYETVPIDSSKTGDGNVTNKAEGSTDSN 2147
            |..:|... ..|..|:.. ||. :...|:|..|  ....|..|:....|...|  |:...||.:.
Human   243 NGESSSFA-PTDNASVTG-TPV-VSEENALSPNCTSTTVEDPPVQEILTSSEN--NECIPSTSAE 302

  Fly  2148 IYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASV 2212
            :..:.:.                        ::|.|.|...:|.:.||..:.:|:
Human   303 LESEARS------------------------ILEPDTSNSRSSSAFEAAKSRQPD---------- 333

  Fly  2213 SPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQ 2277
                           .|:..:.....|.:...|.:..:.:.|               ..|..:|.
Human   334 ---------------GCMDPVRQQSGNANTETLPSGWEQRKD---------------PHGRTYYV 368

  Fly  2278 SNFSELPSWNF---LLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNG 2339
            .:.:...:|..   |...|:..:|...||:.    ::|.:.....:         |..||.:||.
Human   369 DHNTRTTTWERPQPLPPGWERRVDDRRRVYY----VDHNTRTTTWQ---------RPTMESVRNF 420

  Fly  2340 QQRDLVLCKLERNRESLIVQTFKEL-----------NTQFGNQSRRIQPPITFNRV--------- 2384
            :|     .:.:||:....:|.|.:.           |..:|.     .||....||
Human   421 EQ-----WQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGP-----LPPGWEKRVDSTDRVYFV 475

  Fly  2385 ----KVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVS 2445
                |.|..::|.             .:.|.....:|....::......:|.|..::  |:.|..
Human   476 NHNTKTTQWEDPR-------------TQGLQNEEPLPEGWEIRYTREGVRYFVDHNT--RTTTFK 525

  Fly  2446 GSSRDQSTLQRRGS----NSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQI 2506
            .....:|::.:.|.    .....|:.|..|.....:|.|                .|:
Human   526 DPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALP----------------SHV------- 567

  Fly  2507 GERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKS------- 2564
                  ||:...||        |.|....|::::...|  ||:::     .:.|:.:.
Human   568 ------KINVSRQT--------LFEDSFQQIMALKPYD--LRRRL-----YVIFRGEEGLDYGGL 611

  Fly  2565 --ETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLC 2627
              |.....|....:|...:.:....:|..|..:|...  ..|       :.::.|..|||.|.:.
Human   612 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAST--INP-------DHLSYFCFIGRFIAMA 667

  Fly  2628 LLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVI 2692
            |...:.:.........|.:|.:|:...||...|...|.|...|..|...:.|      :|:.|.:
Human   668 LFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECG------LEMYFSV 726

  Fly  2693 DLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMIN 2757
            |:.......:.:|..||.::.||..|..||:...||:|..:..::..:|..||..:|:|...:..
Human   727 DMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQY 791

  Fly  2758 LTAEDLRLLLNGVGDINV-----STLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDL 2817
            ...::|.::|.|:.::::     :|:..:.|.|.:      :::    |||..|::.:...|..|
Human   792 FDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSK------QII----WFWQFVKETDNEVRMRL 846

  Fly  2818 VYFWTGSPALPASEEGFQ-------PLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKM 2875
            :.|.||:..||..  ||.       |......:...|:.||.::||.:||.:|.|.|...|:.|:
Human   847 LQFVTGTCRLPLG--GFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKL 909

  Fly  2876 LMAI-KSKNFG 2885
            |.|| :::.||
Human   910 LFAIEETEGFG 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/62 (18%)
		HECTc	2589..2885	CDD:238033	75/308 (24%)
		HECTc	2589..2884	CDD:214523	75/307 (24%)
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	27/143 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..388		39/251 (16%)
		HUL4	<307..922	CDD:227354	144/787 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900