DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Plekha5

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_006506926.1	Gene:	Plekha5 / 109135	MGIID:	1923802	Length:	1270	Species:	Mus musculus

Alignment Length:	1337	Identity:	252/1337 - (18%)
Similarity:	431/1337 - (32%)	Gaps:	385/1337 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1445 IVKCTSDHLDTLLLTLVRELQNASV-SNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSH 1508
            :...||:......::::.|..|.:: |:.:......|.|..|:..:|   .|..|:.|..||..:
Mouse   107 VATMTSEDKKERPISMINEASNYNMASDYAVHPMSPVGRTSRASKKV---HNFGKRSNSIKRNPN 168

  Fly  1509 SSCNK----YVQSC--VKVFQTLHKISIEELC------EVSEALIAPVRLGVVRPTAPFTMSSSN 1561
            :...:    |.|..  :|:::....: :.:||      |..|.::..:.|    |:....|.::.
Mouse   169 APVVRRGWLYKQDSTGMKLWKKRWFV-LSDLCLFYYRDEKEEGILGSILL----PSFQIAMLTAE 228

  Fly  1562 LDVRNSDDLFSVDPLAPSNVESPSEQILVHDAGNDQSANFNIQQNYDVVAMETIR---------- 1616
             |..|....|..   |..|:.:   .....|.|.:.........:..:|..|.::
Mouse   229 -DHINRKYAFKA---AHPNMRT---YYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDK 286

  Fly  1617 ---DASESEE---------VINREANSHNQDDEL--IENQR----NEDGMQDDESD------NDF 1657
               |::.::|         :|..|..:|.::.|:  ||.:|    ...|.|.|..|      |..
Mouse   287 ITTDSASTKETNNIPNHRVLIRPEVQNHQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSV 351

  Fly  1658 TFNDAETESDSDDNQSNQEVQ-RSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQ 1721
            ..|...:|.:|..:...|.|. |.:...::.|...::.   |.|..|.|  ....|....|:|..
Mouse   352 KLNSLLSEYESGPDCPPQNVHYRPINVNSSDGKAVNVS---LADVRGGS--HPNAGPLATEADRV 411

  Fly  1722 SDEFNFNEQQLER-------RSTNSNARSDLAPQTMQWAIRSRDTARSSV--RVPTGSNMVFIDP 1777
            ....| :.||||:       |......|..::.||:.   |:..:.|:.:  |.|.|..     .
Mouse   412 IQRTN-SMQQLEQWIKVQKGRGLEEEPRGVISYQTLP---RNMPSHRAQILARCPEGYR-----T 467

  Fly  1778 MALRRSTVPASTTVTT--------PSIEPHTMATTASNLARAFGITIRQISELISIL-------- 1826
            :.....|.|.|....|        |..|....:.....:.:.:....||.....|.|
Mouse   468 LPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSS 532

  Fly  1827 -------SYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFG-AYLTNY 1883
                   |...::.|.||  ..:..|.|.|.|..:|         |......:.::.| ..:...
Mouse   533 PKAMVQVSDQTMHSIPTS--PSHGSAAAYQGFSPQR---------TYRSEVTSPIQRGDVTIDRR 586

  Fly  1884 TDPNHPLH---------PLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRSHT 1939
            ..|:||.|         |..|:.||.|.|:....|...:..:.|.....:.:     ||.:|.||
Mouse   587 HRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTPEELTLLLIKLRRQQAE-----LSSVREHT 646

  Fly  1940 -------------------SEH------------RDALPVLDI-------TALRHIAYVLDAFVY 1966
                               |.|            ::..|::.:       :|||...|  ..|:.
Mouse   647 LAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLY--QQFLR 709

  Fly  1967 YMRNDSGFYDKQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPS--GSQGTRRHA 2029
            .....|.:...||...|.:....|  |....|.:|:.|.|.:..|:.....:..  ..:.|...|
Mouse   710 QKNKISLYCLSQDECRGTLYKYRP--EEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQA 772

  Fly  2030 FFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATND 2094
            ..:.|:             |:.::...|.|.:..:||    |.:|...   |::|....|.||.:
Mouse   773 LLSASQ-------------EIEMNADNPAAIQTVVLQ----RDDLQNG---LLSTCRELSRATAE 817

  Fly  2095 GDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGD---------GNVTNKAEGSTDSNIYV 2150
                               |:|..|.|:.:..|.:.|.|         |.|.:::.|...:.|..
Mouse   818 -------------------LERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQK 863

  Fly  2151 QLKKKQG-SDDFKSHKEADGNQS-------------KYEKVVLMETDDSLPSTSKSTEALMATRP 2201
            :|.:.|. .:....||:..|:..             ||:.    |.::.:|.......:...|..
Mouse   864 ELWRIQDVMEGLSKHKQQRGSSETVGLAGSKPFSSVKYKS----EEEEVVPPRPPLPRSYDFTEQ 924

  Fly  2202 EVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLL 2266
            ..||.|                      |.:..|.:..||...:...|..|.. |.|.
Mouse   925 PPIIPP----------------------LPSDSSSLLCYSRGPVHLPEDKKIH-QVQG------- 959

  Fly  2267 LFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHG---------SVLPELRG- 2321
             :|..||...       |.:....|..:||.       :.:|...:|         :..|.::|
Mouse   960 -YPRNGSHCG-------PDYRLYKSEPELTT-------VAEVDESNGEEKSEPVSETEAPVVKGS 1009

  Fly  2322 -FPV-------------------KEMRFRRHMEKLRNGQQRDLV--LCKLERNRESLIVQTFKEL 2364
             |||                   ..:|..:.|.:||..:.|..|  ||..|..|..:.|:...|
Mouse  1010 HFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLE- 1073

  Fly  2365 NTQFGNQSRRIQPPITFNRVK---VTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGT 2426
                  :.||.|......:.|   |....:|.:    .|.....:.:.|.....:..|::|. ..
Mouse  1074 ------RIRRHQQACLREKKKGLSVLGASDPSD----VRDSPLRLTQTLRRDDNVKELDTVH-RE 1127

  Fly  2427 NHSK--YVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTP-PN--S 2486
            |..|  |..|.:...........:.|   :.|:...|::|                ||| ||  :
Mouse  1128 NDVKPDYETPAAQCAHLEDAEPQNAD---IGRKLKRSEML----------------YTPEPNGMA 1173

  Fly  2487 SDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGML---LEIPTPQLLSVISSDETLR 2548
            |:..|.:              ||...::|:.......:.|.|.   :|.|..:..|:...:|||
Mouse  1174 SEEVTEK--------------ERQKEQVHADGSCSPQEETAMTEHQMEGPPEEAESLHEEEETL- 1223

  Fly  2549 QKVNEAIEIITFKQKSETSAQSSQPKKSP-SVVVVDP 2584
            .....|.||   .::::|:.:|..|  || |....||
Mouse  1224 ASCEPAPEI---PRENQTTVRSLSP--SPDSSTAADP 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	45/232 (19%)
		PolyA	2498..2561	CDD:197769	14/65 (22%)
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
Plekha5	XP_006506926.1	WW	13..42	CDD:366073
		WW	59..88	CDD:366073
		PH_PEPP1_2_3	165..268	CDD:270068	18/114 (16%)
		Smc	<623..>864	CDD:224117	51/288 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900