DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and Wwp1

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_796301.2 Gene:Wwp1 / 107568 MGIID:1861728 Length:918 Species:Mus musculus


Alignment Length:947 Identity:188/947 - (19%)
Similarity:328/947 - (34%) Gaps:254/947 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  2061 KPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGD-----GGSIFDYTPTRLGFSNSLKRNERV 2120
            |..||..|.|.:::...|.|.:   .|.:|....|:     .|.:.:..|.....|:.       
Mouse   102 KQVLLTHNRKLEKVKEQLKLSL---ENKNGIVQTGELTVVLDGLVIEQEPVTNRSSSP------- 156

  Fly  2121 YETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDS 2185
                ||:..:.||. :....:.:|.:...:.::...|.|:..|......| |....||..|...|
Mouse   157 ----PIEIQQNGDA-LHENGDPATRTTPRLPVEGTIGIDNHVSTNTVVPN-SCCSHVVNGENTPS 215

  Fly  2186 LPSTSKSTEALMATRPEVIIAPNKASVSPAT---AARSVIVLAGG-SCLKTIDSDINNYSASNLS 2246
            .||.       :|.||:...||...:.:|.:   ...|..|||.. |.:.|:....:..|.||.:
Mouse   216 SPSQ-------VAARPKNAPAPKPVTSAPTSDTVNGESSSVLADNTSTMGTLLPSEDTTSTSNCT 273

  Fly  2247 TAEQAKCDTQYQKSTSDHLLLFPARGS-------------------------------------Q 2274
            :....:...|...::|:|....|:..:                                     |
Mouse   274 STTTQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSVFDKVRQPEGCVEPLRPQ 338

  Fly  2275 FYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDD-----VGMEHGSVLPELRGFPVKEMRF----- 2329
            ...:|...||      |.|:...|..||.:..|     ...|....||     |..|.|.     
Mouse   339 SGNTNTEALP------SGWEQRKDPHGRTYYVDHNTRTTTWERPQPLP-----PGWERRVDDRGR 392

  Fly  2330 --------------RRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKEL-----------NTQFG 2369
                          |..||.:||.:|     .:.:||:....:|.|.:.           |..:|
Mouse   393 VYYVDHNTRTTTWQRPTMESVRNFEQ-----WQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYG 452

  Fly  2370 ----NQSRRIQPP-----ITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVG 2425
                ...:|:...     :..|.....::|...:|                    :||.|.:..|
Mouse   453 PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG--------------------LPNEEPLPEG 497

  Fly  2426 -----TNHS-KYVVPFSSILRSRTVSGSSRDQSTLQRRGS----NSKILWRSARERKALNLDARP 2480
                 |... :|.|..::  |:.|.......:|::.:.|.    .....|:.|..|.....:|.|
Mouse   498 WEIRYTREGVRYFVDHNT--RTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALP 560

  Fly  2481 YTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDE 2545
                            .|:             ||:...||        |.|....|::::...| 
Mouse   561 ----------------SHV-------------KINVSRQT--------LFEDSFQQIMALKPYD- 587

  Fly  2546 TLRQKVNEAIEIITFKQKS---------ETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGF 2601
             ||:::     .:.|:.:.         |.....|....:|...:.:....:|..|..:|...  
Mouse   588 -LRRRL-----YVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAST-- 644

  Fly  2602 YTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYES 2666
            ..|       :.::.|..|||.|.:.|...:.:.........|.:|.:|:...||...|...|.|
Mouse   645 INP-------DHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNS 702

  Fly  2667 FRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRL 2731
            ...|..|...:.|      :|:.|.:|:.......:.:|..||.::.||..|..||:...||:|.
Mouse   703 LIWIRDNNIEECG------LEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRF 761

  Fly  2732 IKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINV-----STLISYTTFNDESSEG 2791
            .:..::..:|..||..:|:|...:.....::|.::|.|:.::::     :|:..:.|.|.:    
Mouse   762 SRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSK---- 822

  Fly  2792 PDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQ-------PLPSVTIRPADDSH 2849
              :::    |||..|::.:...|..|:.|.||:..||..  ||.       |......:...|:.
Mouse   823 --QII----WFWQFVKETDNEVRMRLLQFVTGTCRLPLG--GFAELMGSNGPQKFCIEKVGKDTW 879

  Fly  2850 LPTANTCISRLYIPLYSSKSILRSKMLMAI-KSKNFG 2885
            ||.::||.:||.:|.|.|...|:.|:|.|| :::.||
Mouse   880 LPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562
PolyA 2498..2561 CDD:197769 11/62 (18%)
HECTc 2589..2885 CDD:238033 75/308 (24%)
HECTc 2589..2884 CDD:214523 75/307 (24%)
Wwp1NP_796301.2 C2_E3_ubiquitin_ligase 17..140 CDD:175988 10/40 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..182 6/43 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..360 30/163 (18%)
Interaction with ERBB4. /evidence=ECO:0000269|PubMed:19561640 345..525 39/217 (18%)
WW 347..376 CDD:278809 9/34 (26%)
WW 379..408 CDD:278809 5/33 (15%)
WW 454..483 CDD:278809 2/28 (7%)
WW 495..524 CDD:238122 6/30 (20%)
HECTc 564..916 CDD:238033 89/393 (23%)
HECTc 587..915 CDD:214523 82/361 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.