Protein Alignment hyd and YAP1

DIOPT Version :9

• Sequence 1: NP_001287262.1
• Gene: hyd / 41181
• FlyBaseID: FBgn0002431
• Length: 2887
• Species: Drosophila melanogaster
• Sequence 2: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 107/579 - (18%)
• Similarity: 178/579 - (30%)
• Gaps: 208/579 - (35%)

  Fly  1886 PNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLD 1950
            |:.|..|...:.||:....||......|.|      :|..|......::|...|:.....:|:
Human    30 PSGPGQPAPAATQAAPQAPPAGHQIVHVRG------DSETDLEALFNAVMNPKTANVPQTVPM-- 86

  Fly  1951 ITALRHIAYVLDAFVYYMRNDSGFYDKQ-DTISGRINNLSPMTESYDTDDELANLEEFNADVQMS 2014
              .||.:.   |:|  :...:...:.:| .|.:|....|:|
Human    87 --RLRKLP---DSF--FKPPEPKSHSRQASTDAGTAGALTP------------------------ 120

  Fly  2015 ASSMPSGSQGTRRHAFFARSESTLSLGCSAP-----------------------EGFELPLDMAM 2056
                    |..|.|:    |.::|.||..:|                       ..||:|.|:.:
Human   121 --------QHVRAHS----SPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPL 173

  Fly  2057 PLADKPHLLQPNSKRQELFANLPLLVTT------------------------NANN--SGATNDG 2095
            |...:   :...|..|..|.|.....||                        |..|  ||...||
Human   174 PAGWE---MAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDG 235

  Fly  2096 ------DGGSIF---------DYTPTRLGFSNSLKRNERVYETVPID-----SSKTGDGNVTNKA 2140
                  ..|.|:         .:...||........|:|:.::.|:.     :.::..|.|.
Human   236 WEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFGKAMNQRISQSAPVKQPPPLAPQSPQGGVM--- 297

  Fly  2141 EGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVII 2205
             |.::||...|::.:|             .|.:.|::.|           |..|.|...||:.:
Human   298 -GGSNSNQQQQMRLQQ-------------LQMEKERLRL-----------KQQELLRQVRPQAM- 336

  Fly  2206 APNKASVSPATA-ARSVIVLAGGSCLKTIDSD-------------------INNYSASNLSTAEQ 2250
                .:::|:|| :.....||..|.|.|::.|                   ..|.|...|::...
Human   337 ----RNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTY 397

  Fly  2251 AKCDTQYQKSTSDHLLLFPARGSQFYQS----------NFSELPSW-----NFLLSRWKLTLDLF 2300
            ...|.......|......|.....|..|          |.|.|||.     ::|.:.....:||
Human   398 HSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDL- 461

  Fly  2301 GRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDL--VLCKLERNRESLI 2357
            |.:..|.:.:|...::|.|:             |.|.:....|:  ||...:.::||.:
Human   462 GTLEGDGMNIEGEELMPSLQ-------------EALSSDILNDMESVLAATKLDKESFL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
YAP1	XP_005271435.1	WW	174..203	CDD:238122	7/31 (23%)
		WW	232..261	CDD:366073	4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900