DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and ubr5

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:XP_004915163.2 Gene:ubr5 / 100490232 XenbaseID:XB-GENE-939896 Length:2794 Species:Xenopus tropicalis


Alignment Length:3094 Identity:1226/3094 - (39%)
Similarity:1741/3094 - (56%) Gaps:507/3094 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVSMQFVLQPLPGSDDQFIERIREVSDKVNRFGYGSH---RIFEQLKIPVKEVVIGPAHIGVLLE 62
            |.|:.||:.||||::||..:|:||||:|:|::...||   .:.||..|  |:.|:||.|...|||
 Frog     1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLSSHPPLNVLEQTTI--KQCVVGPNHAAFLLE 63

  Fly    63 DGKAFRVSFSINSEKLDLTKSD----AKCSTSGGSGTAS----ASKAP---SSSRPMARSRARLL 116
            ||:..|:.||:..::|:|:|.:    :|.|:..|:|..|    .|.:|   |.|..:.|.....|
 Frog    64 DGRICRIGFSVQPDRLELSKPENNDGSKLSSGSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTL 128

  Fly   117 RATGRSNSTGQGSGS------------RSTGVII------GGSTSSRPLVTVPATYVPEELISQA 163
            .:...|...|.|.||            |.|.||.      .|...|:|...:||:.:||||||||
 Frog   129 GSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQA 193

  Fly   164 EVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEEAEDTEEGA-DNYVP-EDLISLLDNGFSG 226
            :||||||||::|||||||||||||||||||||||||:.:|.::.| ::|:| |||:||||.....
 Frog   194 QVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHS 258

  Fly   227 DNNSVIIDPSDGLFSEEI-FSNYSSIRNLLFDRIRSERSNANANAADSNQSTTRSTSSGTALTGN 290
            .:.||||| :|.:|||:| :..|.|.|.....||.|.|........||                 
 Frog   259 AHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRIGSSRVLLLPLERDS----------------- 305

  Fly   291 SGLSAQISVNADREAFSRWRDRQYYGPRRWISKDDYTWEKDADSKKKEP------SPMLSPIWIS 349
                   .:..:||:..|.|:      |||:....:..|:.:.||:.||      :|:.||:.:.
 Frog   306 -------ELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPALDKKNTPIQSPVSLG 357

  Fly   350 EELQPWPEKSSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYKSETEN--VYHPKTVSLNIV- 411
            |:||.||||...:|.:|||||||.:|:|..|:||||:|.::|||:: |:|  ::||:...|.:. 
 Frog   358 EDLQWWPEKDGTKFISIGALYSELVAVSSKGELYQWKWMESEPYRN-TQNLSLHHPRASFLGLTN 421

  Fly   412 ERVELISANFIRCSVVTETNRVATWMDEQLGYIGAKLEHSCCAFNEFISDSITKIYVCSLYTVVK 476
            |::.|:|||.||.:|.||:|:||||:||.|..:.:||||:...|.|...|.|..::.|:|||..:
 Frog   422 EKIVLLSANSIRATVATESNKVATWVDETLSSVASKLEHTAQIFPELQGDKIVSLHCCALYTCAQ 486

  Fly   477 TESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVA----TDINVGAQVIMKKCPMYQSGSIGFT 537
            .| ||:|||||:||.||:.:.:|.|.|.|||.....    .:|.||.||.::..|:|.:|::.|:
 Frog   487 LE-NNLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFS 550

  Fly   538 CSNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPST 602
            .|.|:||||.|:.|||...|.||.::.:..:...::|                            
 Frog   551 ISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNLEK---------------------------- 587

  Fly   603 GSSKNGQSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTS-----HKRTKRATTKEDSNAPQEGR 662
             ::|..::...||:...:.:|.|||||| |||||..|:.|     :|| :|:|.     ||:|..
 Frog   588 -TNKTTEAKPESKQEPVKTEMGPPPSPA-STCSDASSIASSASMPYKR-RRSTP-----APKEEE 644

  Fly   663 K-DEELWEVKDVVFVED-KVGPVGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKE 725
            | :||.|.:::|||||| |..||||||||||.:|||:||            .||:.||...|   
 Frog   645 KVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFP------------GTSNNSNNQCT--- 694

  Fly   726 EGKEDD----WQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVDSRGI 786
            .|.:.|    .|.|||||.:::|:.:|..:.:.||..|:.|||:.:   ....:||.:.|||:|:
 Frog   695 PGCDPDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCI---PEKTEILAVNVDSKGV 756

  Fly   787 HVIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNG 851
            |.:.|....:.|.:::|...|.||...|||...:|:|....|:.:.    .:|..|.|:||||||
 Frog   757 HAVLKTGTWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIF----TAGQESPIILRDGNG 817

  Fly   852 ALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLPAMLSGVNLKSKVCMTALLFDT---QKLMPH 913
            .:||:||||:|.|:||.|.||||:.|:.|...||..:.:...:|.|..:..:..:.   |.||.|
 Frog   818 TIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLTNLPANSTIKKKAAIIIMAVEVCIKQTLMQH 882

  Fly   914 ILRCDVKNSFAALGRLEREDQAD--TALV---VEERCDGARNIFHACVIMCAPSSNKDSPPDSPS 973
            |||||.:.....|..||:....|  |.::   :..||||.|||.||||.:|.|:|||::..:..:
 Frog   883 ILRCDYEACRQYLMNLEQGVVLDPNTQMLQTFLSHRCDGNRNILHACVSVCFPTSNKETKEEEEA 947

  Fly   974 GGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTSRDNRTN 1038
            ...|:.:.           ....:.|.:||...|..|||.       ..:.|||:||.|    ..
 Frog   948 ERSERNTF-----------AERLSAVEAIANAISVVSSNG-------PGNRAGSSSSRS----LR 990

  Fly  1039 LRDMMNRLIN-----------SDQAEQSGSQPMATNNEDHAYIPWPAE-----------TPAASN 1081
            ||:||.|.:.           |...:...|.|:|    ..:::|.|..           .||..:
 Frog   991 LREMMRRSLRAAGLGRHEAGASSDHQDPVSPPIA----PPSWVPDPPAMDPDGDIDFILAPAVGS 1051

  Fly  1082 LSASSS---QNVSDSIEDDISKIIPS-SSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQMCVS 1142
            |:.:|:   |..|.|       .||. ||:.|::.:            ..|:.:|..||:.:|.|
 Frog  1052 LTTASTVPGQGPSTS-------TIPGPSSEPSVVES------------KDRKANAHFILKLLCDS 1097

  Fly  1143 PALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILML-------SEQDPQLKEAMIFP 1200
            ..|:|||..:||.|||:|.||||.:||.|||.|.|.:|.|...:       ||::..:.:.||.|
 Frog  1098 IVLQPYLRDLLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEANSSEKEEDVFKGMICP 1162

  Fly  1201 NGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKLKR 1265
            .|:.||.|||:|:|.|||||||||||:||||:||||:||||..||||||||||||||||||||||
 Frog  1163 PGTNADDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKR 1227

  Fly  1266 TAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQ 1330
            |:||||||||||||||.||||..:.|..||.:|::.|:|||..||:||.|||||:|||.||.||.
 Frog  1228 TSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTITNLVTMPNSRGEHILLFLVQTVARQTVEH 1292

  Fly  1331 RQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLIDWNAV 1395
            .||| ..|:|.              ..|||.:..| |:||||||||||:||:.||||:|.||||:
 Frog  1293 CQYR-PPRIRE--------------DRNRKAANPE-DSDMPDHDLEPPRFAQLALERVLQDWNAL 1341

  Fly  1396 RSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSD--HLDTLLL 1458
            :||||.|::....|..|.|...:...|. .:::..|.|:..||.|||.||||||:|  .|||||.
 Frog  1342 KSMIMFGSQENKDPLSASSRIGHLLPEE-QVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLG 1405

  Fly  1459 TLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQSCVKVFQ 1523
            |||:||||.....|.:||..|..||:|||||||||.::|.   ...:|.::...:.:..|.:|||
 Frog  1406 TLVKELQNKYTPGRREEAVAVTMRFLRSVARVFVILSVEM---ASSKKKNNFIPQPIGKCKRVFQ 1467

  Fly  1524 TLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLD-VRNSDDLFSVDPLAPSNVESPSEQ 1587
            .|...::||||.|:|:||.|||:|:.|||||||::|:::| ::.|::||||:||.|    .||  
 Frog  1468 ALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPP----RPS-- 1526

  Fly  1588 ILVHDAGNDQSANFNIQQNYDVVAMETIRDASESEEVINR-----------------------EA 1629
                   :|||.:.|..|:..::.....|..|:|:.|..|                       |.
 Frog  1527 -------SDQSNSSNQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEE 1584

  Fly  1630 NSHNQDDELIENQRNEDGMQD--DESDNDFTFN---DAETESDSDDNQSNQE---VQRSVQAGAT 1686
            :.|::.:|..|.....:|..|  ||..:|...:   .|||||||:.|.|||:   .:|||...||
 Frog  1585 DHHDEQEEHGEENTEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAAT 1649

  Fly  1687 VGSE---NDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNAR-SDLAP 1747
            .|||   :.:...|.||:|..:.:.:.| |...:|||...|....::.|||.|.:::|. :..||
 Frog  1650 AGSEAGASSVPAFFSEDDSQSNDSSDSD-SSSSQSDDLDQETFMIDEPLERSSNSNHANGAAQAP 1713

  Fly  1748 QTMQWAIRSRDTAR------SSVRVPTGSN--MVFIDPMALRRSTVPASTTVTTPSIEPHTMA-- 1802
            ::||||:|:..:.|      |:...|..|:  :::|:|.:||||. ..|::....::|....:  
 Frog  1714 RSMQWAVRNTQSQRAPNTTPSNTSTPAASSGALIYIEPSSLRRSG-NMSSSAAAAALEASNSSSY 1777

  Fly  1803 -TTASNLARAFGITIRQISELISIL-SYN--VLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWM 1863
             |:||:||||:.|.|||||:|:.:: .||  |.:.|..::|:...:|:.:|.:||::|..||:||
 Frog  1778 LTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWM 1842

  Fly  1864 FTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVN----------I 1918
            .::||.|||||::|:.|.:..||.||.|||:.|..::..:.......:|:..:.          .
 Frog  1843 VSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSNRRERMTAREEASLRTLEGRRRATLLSAR 1907

  Fly  1919 MGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISG 1983
            .|.::|.||..|.|||||||..||.|.|||||:.:|:|:|||..|.:|:::    ..::|.|:. 
 Frog  1908 QGMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIK----AMNQQTTLD- 1967

  Fly  1984 RINNLSPMTESYDT-----------DDELANLEEFNADVQMS---ASSMPSGSQGTRRHAFFARS 2034
                 :|..|...|           |.|..|.::.|..:.::   ..::|  |:....|.||.||
 Frog  1968 -----TPQLERKRTRELLELGLDNEDSEHENDDDTNQSLTLNDKDDDTLP--SETGPNHPFFRRS 2025

  Fly  2035 ESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG-----ATND 2094
            :|...|||..|..||:||..|:||||:|||||||:::::||......:.::..|:|     .|.|
 Frog  2026 DSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSTANTGKCLLEVTVD 2090

  Fly  2095 GDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSD 2159
               .:..:..||::.::::||                   ||.|           :|.::|:..:
 Frog  2091 ---RNCLEVLPTKMSYASNLK-------------------NVMN-----------MQSRQKEAEE 2122

  Fly  2160 DFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVL 2224
                           :.|...|.|.|.|..|....|              |.:..:..|...:..
 Frog  2123 ---------------QNVPAEENDTSKPGPSAHDLA--------------AQLKSSLLAEIGLTE 2158

  Fly  2225 AGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFL 2289
            :.|..|                |:.:.:|                        |....:.|.:.|
 Frog  2159 SEGPPL----------------TSFRPQC------------------------SFMGMVISHDML 2183

  Fly  2290 LSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRE 2354
            |.||:|:|:|||||||:|||.|.||:|.||.||.|||.:|||.||||||.|.|||.| :::|:|:
 Frog  2184 LGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLTL-EVDRDRD 2247

  Fly  2355 SLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNL 2419
            .||.||.::||..||.  |....|:..:||||||||||||||||||||||::|:|.|::.|:|:|
 Frog  2248 LLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAVAQAFLSNEKLPSL 2310

  Fly  2420 ESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARE---RKALNLDARPY 2481
            :.:| ..|...:.   |.:.|.|......|::....||.|..:...|..|:   |:.|::|.||:
 Frog  2311 DCIQ-NANKGTHT---SLMQRLRNRGERDRERERDMRRSSGLRTGSRRDRDRDFRRQLSIDTRPF 2371

  Fly  2482 TPP---NSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISS 2543
            .|.   |.||:..|      |..|.|.:||||||::.::....|.||||||||:...|||.:::|
 Frog  2372 RPASEGNPSDDPDP------LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLAS 2430

  Fly  2544 DETLRQKVNEAIEIITFKQKS------------ETSAQSSQPKK----SPSVVVVDPVD----DD 2588
            :::||.:|:||:|:|....:.            |.:.:..:.:|    |.|||.::..|    ||
 Frog  2431 EDSLRARVDEAMELIIAHGRENGADSILDLGLLEAADKVQENRKRHGSSRSVVDMELTDTDDGDD 2495

  Fly  2589 NEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKF 2653
            |.||||.|||||||:||.|..:..|:|.||||||::|||||||||.|:.|.|.|:|.:||||:.:
 Frog  2496 NAPLFYQPGKRGFYSPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLSRQVIKVLLGRKVNW 2560

  Fly  2654 HDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSN 2718
            ||.||||..:|||.||:|..:|:.:.:.....|:|.|.|||.|||..|..||||.|.::.||..|
 Frog  2561 HDFAFFDHVMYESLRQLILASQSPDADAVFASMDLAFAIDLCKEESGGQVELIPNGVNIPVTPQN 2625

  Fly  2719 IFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTT 2783
            ::||||:|.|:|::...|:.|.|::.|:.||||.|::.:|||||.|||:||.|::||..|||:|:
 Frog  2626 VYEYVRKYAEHRMLTVAEQPLNAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTS 2690

  Fly  2784 FNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDS 2848
            |||||.|..:|||:||:|||||||||::.||||||||||.||:||||||||||:||:||||.||.
 Frog  2691 FNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ 2755

  Fly  2849 HLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887
            |||||||||||||:||||||.||:.|:|:|||:||||||
 Frog  2756 HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409 38/45 (84%)
ZnF_UBR1 1217..1284 CDD:197698 59/66 (89%)
ASF1_hist_chap 1535..1733 CDD:304562 75/232 (32%)
PolyA 2498..2561 CDD:197769 29/62 (47%)
HECTc 2589..2885 CDD:238033 183/295 (62%)
HECTc 2589..2884 CDD:214523 182/294 (62%)
ubr5XP_004915163.2 CUE_UBR5 184..230 CDD:270606 40/45 (89%)
ZnF_UBR1 1179..1246 CDD:197698 59/66 (89%)
PolyA 2385..2448 CDD:197769 30/68 (44%)
HECTc 2469..2791 CDD:214523 190/321 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1332 1.000 Domainoid score I8
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H9295
Inparanoid 1 1.050 1900 1.000 Inparanoid score I58
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D13816at33208
OrthoFinder 1 1.000 - - FOG0007203
OrthoInspector 1 1.000 - - oto104589
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5312
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

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