DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and herc5.4

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	915	Identity:	188/915 - (20%)
Similarity:	299/915 - (32%)	Gaps:	256/915 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  2022 SQGT--RRHAFFARSESTL--SLGC--------------SAPEGFELPLDMAMPLADKPHLLQPN 2068
            ||.|  |.|.......|.|  |.||              |.|....||.:......:|  |:...
Zfish   275 SQVTCGRHHTLVFEESSKLIYSFGCGMQGQLGNGEQVKQSVPLPVLLPTECTEFTMEK--LITGE 337

  Fly  2069 SKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNER-----VYETVPIDS 2128
            .....||...|      .|.|.....|..|.|             |..|:|     |.|:.|..:
Zfish   338 HHSFALFFKNP------GNESEKPKSGSNGGI-------------LTLNDRMIDRWVSESDPWPT 383

  Fly  2129 SKTGDGNVTNKA---EGS---TDSNIYVQLKKKQGSDDF----KSHKEADGNQSKYEKVVLMETD 2183
            .|.....|.:.|   .||   |..:.:.|...:....||    .|..:...::|...:||.:...
Zfish   384 VKNEINTVFSSAASLNGSFLKTSRDEHYQTSVEHCGLDFDLVKTSFAKLFASKSLISEVVKVVQQ 448

  Fly  2184 DSLPSTSKSTEALMATR-----PEVIIAPNKASVSPATAARSVIVLAGGSCLKTID-------SD 2236
            ..|||.:.:...:.|.|     ||:|....|.......|..|.|:....:..|.::       .|
Zfish   449 TLLPSLNPNPTGVEALRLYLLLPELINGLKKQRTKLIEALASKILELNSAARKVLEMYWSRLPDD 513

  Fly  2237 -----INNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFS-ELPSWNFLLSRWKL 2295
                 |..:...:....:|. ||....:||. ||..........||.:.| ::...:|::.:...
Zfish   514 WFERLIKLFHKESTDLIDQI-CDETDHQSTR-HLKNILEILQMAYQISCSTDITHHDFIIHKIND 576

  Fly  2296 TLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQT 2360
            .|||...:..|.:.||                   .:|:  .|....|:|  ||    |....:|
Zfish   577 LLDLLQTITADLLRME-------------------LYMQ--INEDFHDMV--KL----EEYYFRT 614

  Fly  2361 FKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVG 2425
            .|.| .:|...|..|.....||                           ||......|:.::.:|
Zfish   615 VKIL-VKFPFASDFITKQRMFN---------------------------LLQEECFRNVPNLAMG 651

  Fly  2426 TNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNA 2490
            .:       ||::|..                            .|:::..|...|...|:
Zfish   652 NS-------FSNLLHI----------------------------NRESVLTDTLQYLRQNT---- 677

  Fly  2491 TPESLNDHLSVHLQQ---IGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVN 2552
                   |..:|..|   |||                 .|:.:...:.:..|:||.
Zfish   678 -------HSFMHPLQVAFIGE-----------------DGIDMRGLSAEFFSLISK--------- 709

  Fly  2553 EAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAF 2617
               ..|.:.:|.....:|       |:|..:|        .::.|.:.||
Zfish   710 ---SFIEWDKKILEVHES-------SLVWFNP--------HHTRGNKNFY--------------- 741

  Fly  2618 RNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEET 2682
             .:|.:.|:.|.....:.:.....:.|.:|.:|....||....|....|.:.:::    ::.||.
Zfish   742 -YLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLE----EDEEEV 801

  Fly  2683 INRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVF 2747
            :|...|.|.        |..:||:|.|..:.|...|..:||..|.:....||.:...|....|..
Zfish   802 VNLQHLDFT--------CKGQELVPNGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTRGFS 858

  Fly  2748 DVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIM 2812
            ...|.::......|:|:.||:|....|...|....::  |.....|:|:|.   ||::..:::..
Zfish   859 KGCPLDAWTMFHPEELQELLHGSPQYNWKELQQSASY--EGCSASDELIKN---FWTVFFELSEE 918

  Fly  2813 ERQDLVYFWTGSPALPASEEGFQPLP-SVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKML 2876
            .::..:.|..|:..:||.....:.|. |.|..|..|.|||.|.||..||.:|.||..:.|..|::
Zfish   919 NKKKFLMFLYGTERVPAGGLSKRALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDINTLHDKLI 983

  Fly  2877 MAIKS 2881
            .||.|
Zfish   984 HAINS 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/65 (17%)
		HECTc	2589..2885	CDD:238033	71/294 (24%)
		HECTc	2589..2884	CDD:214523	71/294 (24%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274
		RCC1	133..183	CDD:278826
		RCC1	186..235	CDD:278826
		RCC1	239..286	CDD:278826	5/10 (50%)
		RCC1	294..343	CDD:278826	9/50 (18%)
		HECTc	658..993	CDD:294058	92/447 (21%)
		HECTc	682..992	CDD:214523	86/384 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900