DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trbd and otud7a

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_004917978.2	Gene:	otud7a / 779462	XenbaseID:	XB-GENE-1012996	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	468	Identity:	126/468 - (26%)
Similarity:	186/468 - (39%)	Gaps:	140/468 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 ISGSQNDLHASSSLNSQEENQQQLQQPNVDTVSVNNSFNKKHIYQLGSSETINNCDTLQERQERR 327
            :.|...||.|:.|      :.:||:|  |.|.::...||:...|:....|...:.:.:::...:|
Frog    27 LEGKNWDLTAALS------DYEQLRQ--VHTANLPQVFNEGKYYKQQEKEITQHVNKIEKPNLQR 83

  Fly   328 QRQIRRQVDWQWLNACLGVVENNYSAVEAYLSCGGNPARSLTSTEIAALNRNSAFDVGHTLIHLA 392
            |..|                     |.|..||.|.:.|    |:.|.:|.|          :|:|
Frog    84 QDDI---------------------AQEKRLSRGISHA----SSAIVSLAR----------LHVA 113

  Fly   393 IRFHREEMLPMLLDQISGSGPGIKRVPSYVAPDLAADIRRHFANTLRLRKSGLPCHYVQKHATFA 457
            .....|   |..|:           :|.|                                 ||.
Frog   114 NECSSE---PFPLE-----------MPIY---------------------------------TFQ 131

  Fly   458 LPAEIEELPIPIQEQLYDELLDRDAQKQ-----LETPPPALNWSLEITARLSSRMFVLWNRSAGD 517
            ||      .:.:..:.:...::||..:|     || ....||| ...|.....|:..|.....|:
Frog   132 LP------DLSVYSEDFRSFIERDLIEQSTMVALE-QAGRLNW-WSTTCSSCKRLLPLATTGDGN 188

  Fly   518 CLLDSAMQATWGVFDRDNILRRALADTLHQCGHVFFT-----RWKEYEMLQASMLHFTLEDSQFE 577
            |||.:|....||..|||.:||:||. |:.:.|.....     ||::.:..:.|.|.:|  :.::|
Frog   189 CLLHAASLGMWGFHDRDLVLRKALY-TMMRSGAEREALKRRWRWQQTQQNKESGLVYT--EDEWE 250

  Fly   578 EDWSTLLSLA------------GQPG----------SSLEQLHIFALAHILRRPIIVYGVKYVKS 620
            .:|:.||.||            |..|          .|||:.|:|.|||||||||:|.....::.
Frog   251 REWNELLKLASSEPRTHFSKNGGSGGGVDNAEDPVYESLEEFHVFVLAHILRRPIVVVADTMLRD 315

  Fly   621 FRGEDIGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDGRRDDVEDVTYLP 685
            ..||......|.|:||||....|.|..||:.|.|.:.||||||.||       ::|...:...:|
Frog   316 SGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSME-------QKDQQREQAVIP 373

  Fly   686 LMDCELKLLPIHF 698
            |:|.|.||||:||
Frog   374 LIDSEHKLLPLHF 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035
		RanBP2-type Zn finger	11..30	CDD:275376
		ZnF_RBZ	91..114	CDD:197784
		RanBP2-type Zn finger	93..112	CDD:275376
		RanBP2-type Zn finger	175..192	CDD:275375
		ZnF_RBZ	234..256	CDD:197784
		RanBP2-type Zn finger	236..255	CDD:275376
		OTU	513..659	CDD:280496	58/172 (34%)
otud7a	XP_004917978.2	UBA_Cezanne_like	4..46	CDD:270532	7/24 (29%)
		OTU	184..354	CDD:418725	58/172 (34%)
		zf-A20	889..912	CDD:396357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319972at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4304
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950