DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trbd and otud7b

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_002938519.2	Gene:	otud7b / 779455	XenbaseID:	XB-GENE-968436	Length:	868	Species:	Xenopus tropicalis

Alignment Length:	465	Identity:	123/465 - (26%)
Similarity:	195/465 - (41%)	Gaps:	101/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 AALN------RNSAFDVGHTL----------IHLAIRFHREEMLPMLLDQIS-GSGPGIKRVPSY 421
            ||||      :.||..:||:.          :..::|       |||..|.. .....:.|..|:
Frog    39 AALNDYDQLRQTSAGGLGHSFSEGRNFKPPEVGRSVR-------PMLQRQDDVVQEKRLSRGISH 96

  Fly   422 VAPDLAADIRRHFANTLRLRKSGLPCHYVQKH-ATFALPAEIEELPIPIQEQLYDELLDRDAQKQ 485
            .:..:.:..|.|.::      :|...|.::.. .||.||      .:.:.:..:...::||..:|
Frog    97 ASSSIVSLARSHVSS------NGSSEHPLETPVCTFQLP------DLTVYKDEFRNFIERDLIEQ 149

  Fly   486 -----LETPPPALNWSLEITARLSSRMFVLWNRSAGDCLLDSAMQATWGVFDRDNILRRALADTL 545
                 || ....|||..::.... .|:..|.....|:|||.:|....||..|||.:||::|. ||
Frog   150 SMLVALE-HAGRLNWWAQLDPTY-PRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKSLY-TL 211

  Fly   546 HQCG---HVFFTRWKEYEMLQASMLHFTLEDSQFEEDWSTLLSLA------------GQPG---- 591
            .:.|   .....||:.::.:|.........:.:::::|:.|:.||            |..|
Frog   212 MEKGAEKEALKRRWRFHQTMQNKESGLVYTEEEWQKEWNDLIKLASSEPRMHYGTNGGNCGGVES 276

  Fly   592 ------SSLEQLHIFALAHILRRPIIVYGVKYVKSFRGEDIGYARFEGVYLPLFWDQNFCTKSPI 650
                  .|||:.|:|.|||:|:||::|.....::...||......|.|:||||....|.|..||:
Frog   277 SEEPVYESLEEFHVFVLAHVLKRPVVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPPNKCHCSPL 341

  Fly   651 ALGYTRGHFSALVPMEPFTRIDGRRDDVEDVTYLPLMDCELKLLPIHFLTQS----EVGNEESMM 711
            .|.|.:.||||||.||.      :....|...::||.|.:.||||:||....    |.|..:|.
Frog   342 VLAYDQAHFSALVSMEQ------KEQTKEQAPFIPLTDSDHKLLPVHFAVDPGKDWEWGKNDSD- 399

  Fly   712 RQWLDVCVTDGGLLVAQQKLSKRPLLVAQMLEEWLNHYRRIAQVITAPFIRRPQITHYSSD---- 772
                :||:....|.: :.||:   ||...|...||:    :.....||..:....|..:.|
Frog   400 ----NVCLASVTLSL-EAKLN---LLHNYMSVTWLS----LPCETQAPLAQPESPTASAGDDARS 452

  Fly   773 ----GDSDEE 778
                |:||:|
Frog   453 AAESGESDKE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035
		RanBP2-type Zn finger	11..30	CDD:275376
		ZnF_RBZ	91..114	CDD:197784
		RanBP2-type Zn finger	93..112	CDD:275376
		RanBP2-type Zn finger	175..192	CDD:275375
		ZnF_RBZ	234..256	CDD:197784
		RanBP2-type Zn finger	236..255	CDD:275376
		OTU	513..659	CDD:280496	51/170 (30%)
otud7b	XP_002938519.2	UBA_Cezanne_like	7..49	CDD:270532	4/9 (44%)
		OTU	180..350	CDD:388712	51/170 (30%)
		zf-A20	828..851	CDD:366793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319972at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4304
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.040