DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trbd and zranb1b

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_001071236.1	Gene:	zranb1b / 777720	ZFINID:	ZDB-GENE-061110-94	Length:	716	Species:	Danio rerio

Alignment Length:	828	Identity:	348/828 - (42%)
Similarity:	465/828 - (56%)	Gaps:	181/828 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KWKCETCTYENYPSSLKCTMCQASK---PLLNEDIFRLSPAQES--CTVAEEAAAVEVAVMSPTP 69
            ||.||.|||||:||::|||||:|.:   |::.|:.|:.|.:.:.  ||               |.
Zfish     7 KWSCEYCTYENWPSAIKCTMCRAQRHNAPIITEEPFKSSSSLDPSLCT---------------TQ 56

  Fly    70 SSTCYSLQPQSQAR-QSNVAD-----SEKWPCKVCTYLNWPRSLRCVQCCTKRGGEAIERGKKDM 128
            ..:...:.|.|.|| :..:||     |.||.|.:||||||||::||.||.::|
Zfish    57 GGSTLLICPDSSARPRVRIADELPETSSKWSCHMCTYLNWPRAIRCTQCLSQR------------ 109

  Fly   129 DNEADGDRAGEALQALRISGSEENLANKPVQLIGATASHRLSLSRGIDDATHLNNLANASHNQSQ 193
                                                                          |..
Zfish   110 --------------------------------------------------------------QQG 112

  Fly   194 SQHRQPVLQQQMQLQLQPQQQRESSSSAAVP----------PQQQKQCYVSKWACNSCTYENWPR 248
            ||...|         |.|.:..::|.|...|          .:.:...:..:|.|::|||||||:
Zfish   113 SQQHSP---------LSPSETPQTSGSRPSPVTSDPCEEYNDRNRLNMHAQRWPCSACTYENWPK 168

  Fly   249 SIKCSMCGKTREREISGS----QNDLHASSSLNSQEENQQQLQQPNVDTVSVNNSFNKKHIYQL- 308
            |::|.:|...:.   |||    |.|..|.|:.:....|:|  ::.||.|.......::..:.:|
Zfish   169 SLRCVVCDHPKP---SGSPETPQQDSEAESATSPSIVNEQ--ERENVRTAGGGGGGSRGRLRKLS 228

  Fly   309 -----GSSET-------INNCDTLQERQERRQRQIR---RQVDWQWLNACLGVVENNYSAVEAYL 358
                 |.:|.       ....|..||...::.:|||   |:.||.:||||.||||.:.:|||||.
Zfish   229 PPMCKGQAEVKIELASGAVGSDNEQEADFKKLKQIRNRMRRSDWLFLNACAGVVEGDLAAVEAYK 293

  Fly   359 SCGGNPARSLTSTEIAALNRNSAFDVGHTLIHLAIRFHREEMLPMLLDQISGSGPGIKRVPSYVA 423
            |.||:.||.||:.|:..|||.||||.|.||:||||||.|::||.:||.::|..  ..|.:|:.|.
Zfish   294 SSGGDIARQLTADEVRILNRPSAFDAGFTLVHLAIRFQRQDMLAVLLTEVSQQ--TAKCIPALVC 356

  Fly   424 PDLAADIRRHFANTLRLRKSGLPCHYVQKHATFALPAEIEELPIPIQEQLYDELLDRDAQKQLET 488
            |:|...|||..|..|..||...||::.....||.|||:||:||..:||:|:||:||||.||:||.
Zfish   357 PELTEQIRREVAAALHRRKGEFPCYFFTDLVTFTLPADIEDLPPNVQEKLFDEVLDRDVQKELEE 421

  Fly   489 PPPALNWSLEITARLSSRMFVLWNRSAGDCLLDSAMQATWGVFDRDNILRRALADTLHQCGHVFF 553
            ..|.:|||||:..||.||::.||||:||||||||.:|||||::|:|::||::|.|:||.|.|.|:
Zfish   422 ESPIINWSLELGTRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKSLNDSLHDCSHWFY 486

  Fly   554 TRWKEYE--MLQASMLHFTLEDSQFEEDWSTLLSLAGQPGSSLEQLHIFALAHILRRPIIVYGVK 616
            |||||:|  ..|:..|||:|.:.|::|||:.:||||.|||:||||.|:|.|||||||||||||||
Zfish   487 TRWKEWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHVFVLAHILRRPIIVYGVK 551

  Fly   617 YVKSFRGEDIGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDG-------- 673
            |.||||||.:||.||:||||||.|:|:||.|||||||||||||||||.||.    ||
Zfish   552 YYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMEN----DGYDNRGAGA 612

  Fly   674 --RRDDVEDVTYLPLMDCELKLLPIHFLTQSEVGNEES---MMRQWLDVCVTDGGLLVAQQKLSK 733
              ..||...||:|||:|.|.|||.||||:..|:|.||.   |:|||:|.|||:||:|||.||.|:
Zfish   613 NLNTDDDVTVTFLPLVDSERKLLHIHFLSAQEMGTEEQQERMLRQWMDCCVTEGGVLVAMQKSSR 677

  Fly   734 R---PLLVAQMLEEWLNHYRRIAQVITAPFIRRPQITHYSSDGDSDEE 778
            |   | ||.||:|:||:.||::|...|.            |||:.:||
Zfish   678 RRNHP-LVTQMVEKWLDGYRQLAACPTL------------SDGEEEEE 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035	16/27 (59%)
		RanBP2-type Zn finger	11..30	CDD:275376	13/18 (72%)
		ZnF_RBZ	91..114	CDD:197784	15/22 (68%)
		RanBP2-type Zn finger	93..112	CDD:275376	12/18 (67%)
		RanBP2-type Zn finger	175..192	CDD:275375	0/16 (0%)
		ZnF_RBZ	234..256	CDD:197784	11/21 (52%)
		RanBP2-type Zn finger	236..255	CDD:275376	11/18 (61%)
		OTU	513..659	CDD:280496	100/147 (68%)
zranb1b	NP_001071236.1	ZnF_RBZ	7..29	CDD:197784	16/21 (76%)
		RanBP2-type Zn finger	8..27	CDD:275376	13/18 (72%)
		ZnF_RBZ	84..105	CDD:197784	13/20 (65%)
		RanBP2-type Zn finger	86..105	CDD:275376	12/18 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..143		8/38 (21%)
		ZnF_RBZ	156..178	CDD:197784	12/21 (57%)
		RanBP2-type Zn finger	156..175	CDD:275376	11/18 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..228		12/54 (22%)
		ANK 1	268..298		18/29 (62%)
		ANK 2	321..348		14/28 (50%)
		OTU	446..594	CDD:280496	100/147 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594455
Domainoid	1	1.000	230	1.000	Domainoid score	I2385
eggNOG	1	0.900	-	-		E1_KOG4345
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9728
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1044
OMA	1	1.010	-	-		QHG49976
OrthoDB	1	1.010	-	-		D319972at33208
OrthoFinder	1	1.000	-	-		FOG0006358
OrthoInspector	1	1.000	-	-		otm25071
orthoMCL	1	0.900	-	-		OOG6_107708
Panther	1	1.100	-	-	LDO	PTHR13367
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4304
SonicParanoid	1	1.000	-	-		X4629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800