DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trbd and TNFAIP3

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_001257436.1	Gene:	TNFAIP3 / 7128	HGNCID:	11896	Length:	790	Species:	Homo sapiens

Alignment Length:	340	Identity:	96/340 - (28%)
Similarity:	156/340 - (45%)	Gaps:	53/340 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 EEMLPMLLDQISGSGPGIKRVPSYVAPDLAADIRRHFANTLRLRKSGLPCHYVQKHA-TFALPAE 461
            |::||..| .:|.....:|             ||......:....:|:..|:...|. |..:...
Human     3 EQVLPQAL-YLSNMRKAVK-------------IRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRT 53

  Fly   462 IEELPIPIQEQLYDELLDRDAQKQLETPPPALNWSLEITARLSSRMFVLWNRSAGDCLLDSAMQA 526
            .:..| ..:|.::..|:||:.|..||: ...|||..|:     .::..|.....|:||:.:..|.
Human    54 CQFCP-QFREIIHKALIDRNIQATLES-QKKLNWCREV-----RKLVALKTNGDGNCLMHATSQY 111

  Fly   527 TWGVFDRDNILRRALADTLHQCG-HVFFTRW-----KEYEMLQASMLHFTLEDSQFEEDWSTLLS 585
            .|||.|.|.:||:||..||.:.. ..|..||     |..|.::..:.:.|   ..:.::|..|:.
Human   112 MWGVQDTDLVLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDT---RNWNDEWDNLIK 173

  Fly   586 LA---------GQPGSSLEQLHIFALAHILRRPIIVYGVKYVKSFR-GEDIGYARFEGVYLPLFW 640
            :|         |...:|||::|||.|.:||||||||...|.::|.. |.:....:..|:||||.|
Human   174 MASTDTPMARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHW 238

  Fly   641 DQNFCTKSPIALGYTRGHFSALVPMEPFTRIDGRRDDVEDVTYLPLMDCE---LKLLPIHFLTQS 702
            ....|.:.||.|||...||..||.:         :|...::..:||::.:   .:.|.:||||..
Human   239 PAQECYRYPIVLGYDSHHFVPLVTL---------KDSGPEIRAVPLVNRDRGRFEDLKVHFLTDP 294

  Fly   703 EVGNEESMMRQWLDV 717
            |...:|.:::::|.|
Human   295 ENEMKEKLLKEYLMV 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035
		RanBP2-type Zn finger	11..30	CDD:275376
		ZnF_RBZ	91..114	CDD:197784
		RanBP2-type Zn finger	93..112	CDD:275376
		RanBP2-type Zn finger	175..192	CDD:275375
		ZnF_RBZ	234..256	CDD:197784
		RanBP2-type Zn finger	236..255	CDD:275376
		OTU	513..659	CDD:280496	55/161 (34%)
TNFAIP3	NP_001257436.1	TRAF-binding	58..300		81/260 (31%)
		OTU	98..257	CDD:280496	55/161 (34%)
		Interaction with ubiquitin. /evidence=ECO:0000305	157..159		0/1 (0%)
		Interaction with ubiquitin. /evidence=ECO:0000305	190..192		1/1 (100%)
		Interaction with ubiquitin. /evidence=ECO:0000305	224..227		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377
		Interaction with TNIP1. /evidence=ECO:0000250	369..775
		ZnF_A20	384..409	CDD:128555
		Interaction with RIPK1. /evidence=ECO:0000269\|PubMed:19131965	386..453
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..468
		ZnF_A20	475..500	CDD:128555
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..583
		ZnF_A20	604..629	CDD:128555
		Required for proteosomal degradation of UBE2N and UBE2D3, TRAF6 deubiquitination, and TAX1BP1 interaction with UBE2N. /evidence=ECO:0000250	605..655
		Sufficient for inhibitory activity of TNF-induced NF-kappa-B activity. /evidence=ECO:0000250	606..790
		ZnF_A20	654..679	CDD:128555
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..712
		Required for lysosomal localization and for TRAF2 lysosomal degradation	697..790
		ZnF_A20	713..738	CDD:128555
		ZnF_A20	759..784	CDD:128555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4345
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319972at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13367
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920