DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trbd and zranb1a

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_009305260.1	Gene:	zranb1a / 334230	ZFINID:	ZDB-GENE-100212-3	Length:	689	Species:	Danio rerio

Alignment Length:	823	Identity:	332/823 - (40%)
Similarity:	452/823 - (54%)	Gaps:	198/823 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KWKCETCTYENYPSSLKCTMCQASKP---LLNEDIFRLSPAQESCTVAEEAAAVEVAVMSPTPSS 71
            ||.||.||:||:||::|||||:|. |   ::.|:.|..|....:....|...:..:.:   .|.|
Zfish     7 KWSCEYCTFENWPSAIKCTMCRAQXPSGTIITEESFPSSTGPRAGHPWEPERSDSLLI---CPDS 68

  Fly    72 TCYSLQPQSQARQSNVADSEKWPCKVCTYLNWPRSLRCVQCCTKRGGEAIERGKKDMDNEADGDR 136
               |.:|:.:..:|: ..|.||.|:|||||||||::||.||.:.|
Zfish    69 ---SARPRVRPAESS-EPSGKWSCQVCTYLNWPRAVRCTQCRSLR-------------------- 109

  Fly   137 AGEALQALRISGSEENLANKPVQLIGATASHRLSLSRGIDDATHLNNLANASHNQSQSQHRQPVL 201
                   .|:|...:.                                     .|:.|..|:|
Zfish   110 -------QRVSSPTDT-------------------------------------PQTSSTLRRP-- 128

  Fly   202 QQQMQLQLQPQQQRESSSSAAVPPQQQ----------KQCYVSKWACNSCTYENWPRSIKCSMCG 256
                            :|:.||.|.::          .||    |.|.:|||||..:|.:|.:|.
Zfish   129 ----------------ASAPAVDPCEEYNDRNRLNTRTQC----WTCLACTYENALKSFRCVVCD 173

  Fly   257 KTRE---------------REISGSQNDLHASSSLNSQEENQQQL-----QQPNVDTVSVNNSFN 301
            ..|.               |.:.|:... |:..|...:.|.|.:|     .:|
Zfish   174 HPRPNDTFLPPEPEEPSPGRGVCGAAQK-HSPPSSRREAELQIELAAGAHSRP------------ 225

  Fly   302 KKHIYQLGSSETINNCDTLQERQERRQRQIR---RQVDWQWLNACLGVVENNYSAVEAYLSCGGN 363
                               :|...::.:||:   |:.||.:||||.||||.:.||||||.|.||:
Zfish   226 -------------------EEMDFKKIKQIKNRMRKTDWLFLNACAGVVEGDLSAVEAYKSSGGD 271

  Fly   364 PARSLTSTEIAALNRNSAFDVGHTLIHLAIRFHREEMLPMLLDQISGSGPGIKRVPSYVAPDLAA 428
            .||.|.:.|:..|||.||||.|.||:||||||.|::||.:||.::|..  .:|.:|:.|.|:|..
Zfish   272 IARQLNADEVRLLNRPSAFDSGFTLVHLAIRFQRQDMLAILLTEVSQR--AVKCIPAMVCPELTE 334

  Fly   429 DIRRHFANTLRLRKSGLPCHYVQKHATFALPAEIEELPIPIQEQLYDELLDRDAQKQLETPPPAL 493
            .|||..:::|..||....|:::....||.|||:||:||..:||:|:||:||||.||:||.....:
Zfish   335 QIRREISSSLHQRKGDFNCYFLTDLVTFTLPADIEDLPPAVQEKLFDEVLDRDVQKELEEESAVI 399

  Fly   494 NWSLEITARLSSRMFVLWNRSAGDCLLDSAMQATWGVFDRDNILRRALADTLHQCGHVFFTRWKE 558
            |||||:.:||.||::.||||:||||||||.:|||||::|:|::||:.|.|:||.|.|.|:|||||
Zfish   400 NWSLELGSRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKTLHDSLHDCSHWFYTRWKE 464

  Fly   559 YE--MLQASMLHFTLEDSQFEEDWSTLLSLAGQPGSSLEQLHIFALAHILRRPIIVYGVKYVKSF 621
            :|  ..|:..|||:|.:.|::|||:.:|:||.|||:||||.|||.||||||||||||||||.|||
Zfish   465 WESWYSQSFGLHFSLREEQWQEDWTFILNLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSF 529

  Fly   622 RGEDIGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDG----------RRD 676
            ||:.:||.||:||||||.|:|:||.|||||||||||||||||.||.    ||          ..|
Zfish   530 RGDTLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVGMES----DGYDNRGAGANLNTD 590

  Fly   677 DVEDVTYLPLMDCELKLLPIHFLTQSEVGNEES---MMRQWLDVCVTDGGLLVAQQKLSKR---P 735
            |...||:|||:|.|.|||.||||:..|:|:||.   ::|.|||.||||||:|||.||.|:|   |
Zfish   591 DDVTVTFLPLVDSERKLLQIHFLSAQEMGSEEQQERLLRHWLDCCVTDGGMLVALQKSSRRRHHP 655

  Fly   736 LLVAQMLEEWLNHYRRIAQVITAPFIRRPQITHYSSDGDSDEE 778
             |:.||||:||:.||   |:...|.:         |||:.:|:
Zfish   656 -LITQMLEKWLDGYR---QMHPCPTL---------SDGEEEED 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035	16/27 (59%)
		RanBP2-type Zn finger	11..30	CDD:275376	12/18 (67%)
		ZnF_RBZ	91..114	CDD:197784	16/22 (73%)
		RanBP2-type Zn finger	93..112	CDD:275376	13/18 (72%)
		RanBP2-type Zn finger	175..192	CDD:275375	0/16 (0%)
		ZnF_RBZ	234..256	CDD:197784	9/21 (43%)
		RanBP2-type Zn finger	236..255	CDD:275376	9/18 (50%)
		OTU	513..659	CDD:280496	99/147 (67%)
zranb1a	XP_009305260.1	ZnF_RBZ	7..29	CDD:197784	15/21 (71%)
		RanBP2-type Zn finger	8..27	CDD:275376	12/18 (67%)
		ZnF_RBZ	84..105	CDD:197784	14/20 (70%)
		RanBP2-type Zn finger	86..105	CDD:275376	13/18 (72%)
		RanBP2-type Zn finger	153..172	CDD:275376	9/18 (50%)
		OTU	419..567	CDD:280496	99/147 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594456
Domainoid	1	1.000	230	1.000	Domainoid score	I2385
eggNOG	1	0.900	-	-		E1_KOG4345
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1044
OMA	1	1.010	-	-		QHG49976
OrthoDB	1	1.010	-	-		D319972at33208
OrthoFinder	1	1.000	-	-		FOG0006358
OrthoInspector	1	1.000	-	-		otm25071
orthoMCL	1	0.900	-	-		OOG6_107708
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.670