DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trbd and Otud7b

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_001020784.1	Gene:	Otud7b / 229603	MGIID:	2654703	Length:	840	Species:	Mus musculus

Alignment Length:	366	Identity:	101/366 - (27%)
Similarity:	169/366 - (46%)	Gaps:	82/366 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 ELP-IPIQEQLYDELLDRDAQKQ-----LETPPPALNW--SLEITARLSSRMFVLWNRSAGDCLL 520
            :|| :.:.::.:...::||..:|     || ....|||  |::.|.:   |:..|.....|:|||
Mouse   136 QLPDLTVYKEDFRSFIERDLIEQSMLVALE-QAGRLNWWVSMDSTCQ---RLLPLATTGDGNCLL 196

  Fly   521 DSAMQATWGVFDRDNILRRAL---------ADTLHQCGHVFFTRWKEYEMLQASMLHFTLEDSQF 576
            .:|....||..|||.:||:||         .:.|.:     ..||::.:..:.|.|.:|  :.::
Mouse   197 HAASLGMWGFHDRDLVLRKALYALMEKGVEKEALRR-----RWRWQQTQQNKESGLVYT--EDEW 254

  Fly   577 EEDWSTLLSLA--------GQPGS--------------SLEQLHIFALAHILRRPIIVYGVKYVK 619
            :::|:.|:.||        |..|:              |||:.|:|.|||:|:|||:|.....::
Mouse   255 QKEWNELIKLASSEPRMHLGSNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLR 319

  Fly   620 SFRGEDIGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDGRRDDVEDVTYL 684
            ...||......|.|:||||....:.|.:||:.|.|.:.||||||.||       :::..::...:
Mouse   320 DSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSME-------QKESAKEQAVI 377

  Fly   685 PLMDCELKLLPIHFLTQS----EVGNEESMMRQWLDVCVTDGGLLVAQQKLSKRPLLVAQMLEEW 745
            ||.|.|.||||:||....    |.|.:::...:...:      :|..:.||.   ||.:.|..:|
Mouse   378 PLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASI------ILSLEVKLH---LLHSYMNVKW 433

  Fly   746 LNHYRRIAQVITAPFIRRPQITHYSSD--------GDSDEE 778
            :    .::....||..:....|..:.|        |:||:|
Mouse   434 I----PLSSDSQAPLAQPESPTASAGDEPRSTPESGESDKE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035
		RanBP2-type Zn finger	11..30	CDD:275376
		ZnF_RBZ	91..114	CDD:197784
		RanBP2-type Zn finger	93..112	CDD:275376
		RanBP2-type Zn finger	175..192	CDD:275375
		ZnF_RBZ	234..256	CDD:197784
		RanBP2-type Zn finger	236..255	CDD:275376
		OTU	513..659	CDD:280496	52/176 (30%)
Otud7b	NP_001020784.1	UBA_Cezanne_like	4..46	CDD:270532
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..88
		TRAF-binding. /evidence=ECO:0000250	152..401		82/266 (31%)
		Catalytic. /evidence=ECO:0000250	167..440		86/302 (28%)
		Regulatory loop. /evidence=ECO:0000250\|UniProtKB:Q6GQQ9	187..193		0/5 (0%)
		OTU	189..359	CDD:418725	52/176 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..592		8/31 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	483..498
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..710
		zf-A20	798..820	CDD:396357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4345
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4304
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840