DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trbd and OTUD7A

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_001369566.1	Gene:	OTUD7A / 161725	HGNCID:	20718	Length:	933	Species:	Homo sapiens

Alignment Length:	548	Identity:	143/548 - (26%)
Similarity:	215/548 - (39%)	Gaps:	159/548 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 ISGSQNDLHASSSLNSQEENQQQLQQPNVDTVSVNNSFNKKHIYQLGSSETINNCDTLQERQERR 327
            :.|...||.|:.|      :.:||:|  |.|.      |..|::..|..          .:|..|
Human    49 LEGKNWDLTAALS------DYEQLRQ--VHTA------NLPHVFNEGRG----------PKQPER 89

  Fly   328 QRQIRRQVDWQWLNACLGVVENNYSAVEAYLSCGGNPARSLTSTEIAALNRNSAFDVGHTLIHLA 392
            :.|...:|:    ..||  ...:..|.|..||.|.:.|    |:.|.:|.|:          |:|
Human    90 EPQPGHKVE----RPCL--QRQDDIAQEKRLSRGISHA----SSAIVSLARS----------HVA 134

  Fly   393 IRFHREEMLPMLLDQISGSGPGIKRVPSYVAPDLAADIRRHFANTLRLRKSGLPCHYVQKHATFA 457
            ...:.|: .|:             .:|.|                                 ||.
Human   135 SECNNEQ-FPL-------------EMPIY---------------------------------TFQ 152

  Fly   458 LPAEIEELPIPIQEQLYDELLDRDAQKQ-----LETPPPALNWSLEITARLSSRMFVLWNRSAGD 517
            ||      .:.:..:.:...::||..:|     ||.......||...|:  ..|:..|.....|:
Human   153 LP------DLSVYSEDFRSFIERDLIEQATMVALEQAGRLNWWSTVCTS--CKRLLPLATTGDGN 209

  Fly   518 CLLDSAMQATWGVFDRDNILRRALADTLHQCGHVFFT-----RWKEYEMLQASMLHFTLEDSQFE 577
            |||.:|....||..|||.:||:||. |:.:.|.....     ||::.:..:.|.|.:|  :.::|
Human   210 CLLHAASLGMWGFHDRDLVLRKALY-TMMRTGAEREALKRRWRWQQTQQNKESGLVYT--EEEWE 271

  Fly   578 EDWSTLLSLA------------GQPG----------SSLEQLHIFALAHILRRPIIVYGVKYVKS 620
            .:|:.||.||            |..|          .|||:.|:|.|||||||||:|.....::.
Human   272 REWTELLKLASSEPRTHFSKNGGTGGGVDNSEDPVYESLEEFHVFVLAHILRRPIVVVADTMLRD 336

  Fly   621 FRGEDIGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDGRRDDVEDVTYLP 685
            ..||......|.|:||||....|.|..||:.|.|.:.||||||.||       :||...:...:|
Human   337 SGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSME-------QRDQQREQAVIP 394

  Fly   686 LMDCELKLLPIHFLTQS----EVGNEESMMRQWLDVCVTDGGLLVAQQKLSKRPLLVAQMLEEWL 746
            |.|.|.||||:||....    |.|.:::...:...:      :|..:.||:   ||.:.|...|:
Human   395 LTDSEHKLLPLHFAVDPGKDWEWGKDDNDNARLAHL------ILSLEAKLN---LLHSYMNVTWI 450

  Fly   747 NHYRRIAQVITAPFIRRPQITHYSSDGD 774
                ||.....|| :.:|:....|:..|
Human   451 ----RIPSETRAP-LAQPESPTASAGED 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035
		RanBP2-type Zn finger	11..30	CDD:275376
		ZnF_RBZ	91..114	CDD:197784
		RanBP2-type Zn finger	93..112	CDD:275376
		RanBP2-type Zn finger	175..192	CDD:275375
		ZnF_RBZ	234..256	CDD:197784
		RanBP2-type Zn finger	236..255	CDD:275376
		OTU	513..659	CDD:280496	58/172 (34%)
OTUD7A	NP_001369566.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..99		6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..521		4/16 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	501..516
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..620
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..775
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4345
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319972at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4304
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850