DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trbd and zranb1

DIOPT Version :9

Sequence 1:	NP_649931.1	Gene:	trbd / 41179	FlyBaseID:	FBgn0037734	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_001116900.1	Gene:	zranb1 / 100144659	XenbaseID:	XB-GENE-876399	Length:	701	Species:	Xenopus tropicalis

Alignment Length:	807	Identity:	338/807 - (41%)
Similarity:	463/807 - (57%)	Gaps:	154/807 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KWKCETCTYENYPSSLKCTMCQASKP---LLNEDIFRLSPAQESCTVAEEAAAVEVAVMSP--TP 69
            ||.||.|||||:||::|||||:|.:|   ::.|:.|:.|        ..:..::|....||  .|
Frog     7 KWACEYCTYENWPSAIKCTMCRAPRPSGAIITEEPFKNS--------TPDVGSMERESGSPLICP 63

  Fly    70 SSTCYSLQPQSQARQSNVADSEKWPCKVCTYLNWPRSLRCVQCCTKRGGEAIERGKKDMDNEADG 134
            .|   |.:|:.::..| :..|.||.|.:||||||||::||.||.::|
Frog    64 DS---SARPRVKSSYS-METSTKWSCHMCTYLNWPRAIRCTQCLSQR------------------ 106

  Fly   135 DRAGEALQALRISGSEENLANKPVQLIGATASHRLSLSRGIDDATHLNNLANASHNQSQSQHRQP 199
             |.....::.:.|||.......|                 ||.....|:
Frog   107 -RTRSPTESPQSSGSSLRAIPSP-----------------IDPCEEYND---------------- 137

  Fly   200 VLQQQMQLQLQPQQQRESSSSAAVPPQQQKQCYVSKWACNSCTYENWPRSIKCSMCGKTREREIS 264
                :.:|.::.|.                      |.|::|||||..::.||.:|.......:.
Frog   138 ----RNKLNIKGQH----------------------WTCSACTYENCAKAKKCVVCDHPTPNNMD 176

  Fly   265 GSQ--NDLHASSSLNSQE---------ENQQQLQQPNVDTVSVNNSFNKKHIY-QLGSSETINNC 317
            ..:  |...|||.:|.|:         .:..|.:.|.......:..|.:..:. .:||.|..
Frog   177 AIELANTDEASSIINEQDRARWRGGCSSSNSQRRSPPTSKRDSDMDFQRIELAGAVGSKEEF--- 238

  Fly   318 DTLQERQERRQRQIR---RQVDWQWLNACLGVVENNYSAVEAYLSCGGNPARSLTSTEIAALNRN 379
                |...::.:||:   |:.||.:||||:||||.:.||||||.:.||:.||.|::.|:..|||.
Frog   239 ----ELDLKKLKQIKNRMRKTDWLFLNACVGVVEGDLSAVEAYKTSGGDIARQLSADEVRLLNRP 299

  Fly   380 SAFDVGHTLIHLAIRFHREEMLPMLLDQISGSGPGIKRVPSYVAPDLAADIRRHFANTLRLRKSG 444
            ||||||:||:||:|||.|::||.:||.:.|..  ..|.:|:.|.|:|...|||..|.::..||..
Frog   300 SAFDVGYTLVHLSIRFQRQDMLAILLTEFSQH--AAKCIPAMVCPELTEQIRREIAASVHQRKGD 362

  Fly   445 LPCHYVQKHATFALPAEIEELPIPIQEQLYDELLDRDAQKQLETPPPALNWSLEITARLSSRMFV 509
            ..|:::....||.|||:||:||..:||:|:||:||||.||:||...|.:|||||:..||.||::.
Frog   363 FACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSLELGTRLDSRLYA 427

  Fly   510 LWNRSAGDCLLDSAMQATWGVFDRDNILRRALADTLHQCGHVFFTRWKEYE--MLQASMLHFTLE 572
            ||||:||||||||.:|||||::|:|::||:||.|:||.|.|.|::||||:|  ..|:..|||:|.
Frog   428 LWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLHDCSHWFYSRWKEWESWYSQSFGLHFSLR 492

  Fly   573 DSQFEEDWSTLLSLAGQPGSSLEQLHIFALAHILRRPIIVYGVKYVKSFRGEDIGYARFEGVYLP 637
            :.|::|||:.:||||.|||:||||.|||.||||||||||||||||.||||||.:||.||:|||||
Frog   493 EEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLP 557

  Fly   638 LFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDG----------RRDDVEDVTYLPLMDCELK 692
            |.|:|:||.|||||||||||||||||.||.    ||          ..||...||:|||:|.|.|
Frog   558 LLWEQSFCWKSPIALGYTRGHFSALVAMEN----DGFDNRGAGANLNTDDDVTVTFLPLVDSERK 618

  Fly   693 LLPIHFLTQSEVGNE---ESMMRQWLDVCVTDGGLLVAQQKLSKR---PLLVAQMLEEWLNHYRR 751
            ||.||||:..|:|||   |.::|:|:|.|||:||:|||.||.|:|   | ||.||:|:||:.||:
Frog   619 LLHIHFLSAQELGNEDQQEKLLREWMDCCVTEGGVLVAMQKSSRRRNHP-LVTQMVEKWLDGYRQ 682

  Fly   752 IAQVITAPFIRRPQITHYSSDGDSDEE 778
            |          ||...  .|||:.||:
Frog   683 I----------RPCTA--LSDGEEDED 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbd	NP_649931.1	zf-RanBP	11..36	CDD:279035	17/27 (63%)
		RanBP2-type Zn finger	11..30	CDD:275376	13/18 (72%)
		ZnF_RBZ	91..114	CDD:197784	15/22 (68%)
		RanBP2-type Zn finger	93..112	CDD:275376	12/18 (67%)
		RanBP2-type Zn finger	175..192	CDD:275375	3/16 (19%)
		ZnF_RBZ	234..256	CDD:197784	9/21 (43%)
		RanBP2-type Zn finger	236..255	CDD:275376	9/18 (50%)
		OTU	513..659	CDD:280496	101/147 (69%)
zranb1	NP_001116900.1	ZnF_RBZ	7..30	CDD:197784	16/22 (73%)
		RanBP2-type Zn finger	8..27	CDD:275376	13/18 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..59		4/28 (14%)
		ZnF_RBZ	82..102	CDD:197784	13/19 (68%)
		RanBP2-type Zn finger	83..102	CDD:275376	12/18 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..129		4/37 (11%)
		ZnF_RBZ	147..170	CDD:197784	10/44 (23%)
		RanBP2-type Zn finger	148..167	CDD:275376	9/18 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..220		2/21 (10%)
		ANK 1	253..283		18/29 (62%)
		ANK 2	306..333		13/28 (46%)
		OTU	431..579	CDD:280496	101/147 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2402
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9728
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1125
OMA	1	1.010	-	-		QHG49976
OrthoDB	1	1.010	-	-		D319972at33208
OrthoFinder	1	1.000	-	-		FOG0006358
OrthoInspector	1	1.000	-	-		otm49464
Panther	1	1.100	-	-	LDO	PTHR13367
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4304
SonicParanoid	1	1.000	-	-		X4629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110