DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-115b and ABLIM2

DIOPT Version :9

Sequence 1:	NP_731390.1	Gene:	Unc-115b / 41178	FlyBaseID:	FBgn0260463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_005248071.1	Gene:	ABLIM2 / 84448	HGNCID:	19195	Length:	701	Species:	Homo sapiens

Alignment Length:	742	Identity:	217/742 - (29%)
Similarity:	304/742 - (40%)	Gaps:	217/742 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 IYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANC 108
            |.|..|...|.||||||.|.:||..||.|..|...||.||||.:...|.|..||||||||:|.:|
Human    27 ILCNTCGNVCKGEVLRVQDKYFHIKCFVCKACGCDLAEGGFFVRQGEYICTLDYQRLYGTRCFSC 91

  Fly   109 QQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGV 173
            .|::||||||.:|||||..||.|:.|:.||..|.:||..|||.:|::|  ..|||
Human    92 DQFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKECMCQKC--SLPVS---------- 144

  Fly   174 SSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRC 238
                                  :...|||.:..  ..|.|||..:|.||||||||:.||:.||:|
Human   145 ----------------------VGSSAHLSQGL--RSCGGCGTEIKNGQALVALDKHWHLGCFKC 185

  Fly   239 KACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDP 303
            |:|..:||.||:.||.:||||..|...||::|..|.::|:|:||:||:. |:||:||.|.:||..
Human   186 KSCGKLLNAEYISKDGLPYCEADYHAKFGIRCDSCEKYITGRVLEAGEK-HYHPSCALCVRCGQM 249

  Fly   304 FGDGEEMYLQGSAIWHPRCGPG------------PSESGIIL---NGGGGTSSVVGGASNGNFTD 353
            |.:|||||||||:||||.|...            .|||.|.:   :..|..|.|:.....|...|
Human   250 FAEGEEMYLQGSSIWHPACRQAARTEDRNKETRTSSESIISVPASSTSGSPSRVIYAKLGGEILD 314

  Fly   354 -------------TECDR---------MSSSA------------------------LSEMYIRSR 372
                         .:.||         :|.||                        .|....|:.
Human   315 YRDLAALPKSKAIYDIDRPDMISYSPYISHSAGDRQSYGESPQLLSPTPTEGDQDDRSYKQCRTS 379

  Fly   373 TPSFNGSL-------YSSSRKHYR----TVSPG----LILREYGRPNAEDISRIYTYSYLTDAPH 422
            :||..||:       .|.|.:||.    |||.|    |.|.::..|.:     ::.:.|:
Human   380 SPSSTGSVSLGRYTPTSRSPQHYSRPAGTVSVGTSSCLSLSQHPSPTS-----VFRHHYI----- 434

  Fly   423 YLRKPIDPYDKTPLSPHFHRPSSYATTASNAGSVAGSRPPSRPHSRTRSAMKVLVDAIRSETPRP 487
                           |:|....|..:|.| ...::.|:||...:.:......|....::....|
Human   435 ---------------PYFRGSESGRSTPS-LSVLSDSKPPPSTYQQAPRHFHVPDTGVKDNIYR- 482

  Fly   488 KSPGMNNEEPIELSHYPAAKKPPPGEQPKI-----------------ERDDFPAPPYPYTDPERR 535
                   :.||...|.|.|:    .:..|:                 :|...|:||     |...
Human   483 -------KPPIYRQHGPVAQ----SQISKLSGLVSVLSLVVQEAGYGKRQTGPSPP-----PAAA 531

  Fly   536 RRYSDTYKGVPASDDE-----------DENVENGKPNGKVK-----NGEEQQRLQREAEQLEKLN 584
            .|.||...|....|:.           |.:.....|:...:     :|.::..|||.|.  :..:
Human   532 ARRSDGEDGSLDQDNRKQKSSWLMLKGDADTRTNSPDLDTQSLSHSSGTDRDPLQRMAG--DSFH 594

  Fly   585 SGIGSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEP----------LY---------KLRY 630
            |....:.:..|..|.|      |.||.|||:..|..: :|          :|         ::|.
Human   595 SRFPYSKSDPLPGHGK------NGLDQRNANLAPCGA-DPDASWGMREYKIYPYDSLIVTNRIRV 652

  Fly   631 ESPIGASPSRNLDHQKPFYEDEMFDRS 657
            :.|.....:|...|..|....|:|..|
Human   653 KLPKDVDRTRLERHLSPEEFQEVFGMS 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713	24/50 (48%)
		LIM2_abLIM	102..157	CDD:188714	29/54 (54%)
		LIM3_abLIM	211..262	CDD:188715	30/50 (60%)
		LIM4_abLIM	270..326	CDD:188716	31/67 (46%)
ABLIM2	XP_005248071.1	LIM1_abLIM	29..80	CDD:188713	24/50 (48%)
		LIM2_abLIM	85..140	CDD:188714	30/56 (54%)
		LIM3_abLIM	158..209	CDD:188715	30/50 (60%)
		LIM4_abLIM	217..272	CDD:188716	31/55 (56%)
		AbLIM_anchor	282..665	CDD:292800	81/434 (19%)
		VHP	667..701	CDD:280388	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160040
Domainoid	1	1.000	88	1.000	Domainoid score	I7921
eggNOG	1	0.900	-	-		E1_KOG1044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2046
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001360
OrthoInspector	1	1.000	-	-		mtm8549
orthoMCL	1	0.900	-	-		OOG6_103132
Panther	1	1.100	-	-	O	PTHR24213
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11864
SonicParanoid	1	1.000	-	-		X852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780