DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-115b and ablim3

DIOPT Version :9

Sequence 1:	NP_731390.1	Gene:	Unc-115b / 41178	FlyBaseID:	FBgn0260463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_021336718.1	Gene:	ablim3 / 566821	ZFINID:	ZDB-GENE-070112-1122	Length:	690	Species:	Danio rerio

Alignment Length:	718	Identity:	232/718 - (32%)
Similarity:	323/718 - (44%)	Gaps:	173/718 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 IYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANC 108
            |:|.:|.:.|.|||:||...|||..||.|..|...||..|||.|...|.|..||||||||||.:|
Zfish    22 IHCFRCRELCKGEVVRVQHVHFHIKCFTCQVCGCDLAHSGFFQKSGEYICTSDYQRLYGTKCDSC 86

  Fly   109 QQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGV 173
            ..::.|||||.:|:|||.:||.||.|::||..|.:||.:|||.:|:||.... |:|:
Zfish    87 GDFISGEVVSALGRTYHPQCFVCSVCRKPFPIGDRVTFSGKECVCQQCSIKL-VNPN-------- 142

  Fly   174 SSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRC 238
                    .|.:.     ||              |:.||||.|.:|:||:|:||::|||||||||
Zfish   143 --------EPIKI-----HG--------------PSYCAGCKEEIKQGQSLLALEKQWHVSCFRC 180

  Fly   239 KACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDP 303
            :.|..||.|||:.||.|||||..|...||:||..|.|:|||:||:|| ..|:|||||||.:|...
Zfish   181 QTCGLVLTGEYISKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAG-GKHYHPTCARCARCQMM 244

  Fly   304 FGDGEEMYLQGSAIWHPRCGPGP-SESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEM 367
            |.:||||||.||.:|||.|.... :|..:.|......|....|:|..:.:...|.:|.:..|...
Zfish   245 FTEGEEMYLTGSEVWHPVCKQASRTERKLRLRRTSEASISPPGSSISSPSRVICAKMDNEILDYK 309

  Fly   368 YIRSRTPSFNGSLYSSSRKHY-------RTVSPGLILR-EYGR------PNAED--------ISR 410
            .: :..|... ::|...|..|       |..|...:.| .||.      |.::|        :.|
Zfish   310 DL-AALPKVK-AIYEVQRPDYWSYESSHRYCSDDRLERLSYGESLGTLSPYSQDMYDSMDIRMRR 372

  Fly   411 IYTYSYLTDAPHYLRKPIDPYDKTPLSP-HFHRPSSYATTASNAGSVAGSRPPSRPHSRTRSAMK 474
            ..:..|: |:|.|.|:.:.|.  .|.|| |::|   |.|.:..          |.|:.....|
Zfish   373 SSSPGYI-DSPTYSRQGMSPI--MPRSPQHYYR---YGTESGR----------SSPYYSQLDA-- 419

  Fly   475 VLVDAIRSETPRPKSPGMNNEEPIELSHYPAA------KKPP----------PGEQPKIERD--- 520
                  ||.||      ..|:.|... |.||.      :|||          |..:.|...|
Zfish   420 ------RSSTP------TTNQAPKHF-HLPATGEPNIYRKPPIYKRHDNHCNPATKSKTSEDIVQ 471

  Fly   521 --DFPAPPYP------------YTDPER-----RRRYSDTYKGVPASDDEDENVENGKPNGKVKN 566
              .||:...|            ||...:     |||||        |..|::...:|
Zfish   472 SSKFPSAYSPEHYQHSESDYSYYTSSPKSLRAPRRRYS--------SGGEEDGWSHG-------- 520

  Fly   567 GEEQQRLQREAEQLEKLNSGIGSAIAKDLKEHAKYRKWKQNNLDPRNASR-TPSASKEPLYKLRY 630
                         |:::..|||..|   |||..|.|....:| ||..::| :.|.|:|.|:.:.:
Zfish   521 -------------LQRIQGGIGRMI---LKEEMKARSGSYDN-DPWGSARNSRSGSREMLHSMGH 568

  Fly   631 ESPIGASPSRNLDHQKPFYEDEMFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGFKT-TT 694
            .:.:..||..|.     ..|::...:|.|..| .|::..:.|.....:.|.|..:..:|.:. |.
Zfish   569 NNTVNGSPRSNF-----AAENDYISKSASLPG-YGRNGLHRPQSADYYQYDSGSEVNWGIREYTV 627

  Fly   695 LPY 697
            .||
Zfish   628 YPY 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713	23/50 (46%)
		LIM2_abLIM	102..157	CDD:188714	29/54 (54%)
		LIM3_abLIM	211..262	CDD:188715	33/50 (66%)
		LIM4_abLIM	270..326	CDD:188716	32/55 (58%)
ablim3	XP_021336718.1	LIM1_abLIM	24..75	CDD:188713	23/50 (46%)
		LIM2_abLIM	80..135	CDD:188714	29/54 (54%)
		LIM3_abLIM	153..204	CDD:188715	33/50 (66%)
		LIM4_abLIM	212..267	CDD:188716	32/55 (58%)
		AbLIM_anchor	295..654	CDD:318423	92/408 (23%)
		VHP	655..690	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596339
Domainoid	1	1.000	87	1.000	Domainoid score	I7949
eggNOG	1	0.900	-	-		E1_KOG1044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001360
OrthoInspector	1	1.000	-	-		mtm6380
orthoMCL	1	0.900	-	-		OOG6_103132
Panther	1	1.100	-	-	O	PTHR24213
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.750