DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-115b and dmtn

DIOPT Version :9

Sequence 1:	NP_731390.1	Gene:	Unc-115b / 41178	FlyBaseID:	FBgn0260463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001188338.1	Gene:	dmtn / 565367	ZFINID:	ZDB-GENE-030131-9438	Length:	397	Species:	Danio rerio

Alignment Length:	412	Identity:	97/412 - (23%)
Similarity:	140/412 - (33%)	Gaps:	138/412 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 RCGPGPSESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEMYIRS-------------- 371
            :.|..||..|....|...||.|.              ||.:..:....:.:
Zfish     3 KAGTAPSSRGPSAPGSPATSIVA--------------RMDNQVIGYKDLAAIPKDKAILEVERPD 53

  Fly   372 ---RTPSFNGSLYSS---SRKHYRTVSPGLI----------------LREYGRPNAEDISRIYTY 414
               ..|.||.:....   ||...|::||..|                ..|.|.|...::.
Zfish    54 LMVYEPHFNMAALDHVGLSRSRERSMSPHSISPPPSPEISASKELKDWSEQGSPGGSNMG----- 113

  Fly   415 SYLTDAPHYLRKPIDPYDKTPLSPHFHRPSSYATTASNAGSVAGSRPPSRPHSRTRSAMKVLVDA 479
                 :...||| |.|..|.|:. |||||.|..............|....|||:.        |.
Zfish   114 -----STTQLRK-ISPASKGPMQ-HFHRPDSGINLYKKPPIYKNERQTGAPHSKQ--------DL 163

  Fly   480 IRSETPRPKSPGMNNEEPIELSHYPAAKKPPPGEQPKIERDDFPAPPYPYT-DPERRRRYSDTYK 543
            |                 |..|.:|||:.|.|....|||.:.:|.||...| :.|.||:.::  :
Zfish   164 I-----------------IVSSKFPAAQPPDPSLPSKIETEYWPCPPSLATMEIEWRRKAAE--Q 209

  Fly   544 GVPASDDEDENVENGKPNGKVKNGEEQQRLQREAEQLEKLNSGIGSAIAKDLKEHAKYRKWKQNN 608
            |.|..||:.|::.           |:.:|||.  ::|:|:.|.:|..|.|:..|.:...:.|..:
Zfish   210 GKPMEDDDFEDLT-----------EDAKRLQE--QELQKIQSNLGKLILKEEIEKSGLIRRKTRS 261

  Fly   609 L-DPRN------ASRTPSASKEPLYK---LRYES---------------PIGASPSRNLDH---- 644
            | |..|      ||.|.|||..|..:   .|.:|               |.|.|.|..:|.
Zfish   262 LPDGTNIHLGSSASTTKSASLPPCSRTGLTRLQSADFSSTDNGKAKTGVPNGDSQSGRMDRGNSL 326

  Fly   645 ----QKPFYEDEMFDRSTSYRG 662
                ::..|..||.  ..::||
Zfish   327 PSILEQKIYPYEML--IVTHRG 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713
		LIM2_abLIM	102..157	CDD:188714
		LIM3_abLIM	211..262	CDD:188715
		LIM4_abLIM	270..326	CDD:188716	1/4 (25%)
dmtn	NP_001188338.1	AbLIM_anchor	9..361	CDD:292800	95/406 (23%)
dmtn	NP_001188338.1	VHP	363..397	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596340
Domainoid	1	1.000	86	1.000	Domainoid score	I8033
eggNOG	1	0.900	-	-		E1_KOG1044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24213
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800