Protein Alignment Unc-115b and ABLIM1

DIOPT Version :10

• Sequence 1: NP_731390.1
• Gene: Unc-115b / 41178
• FlyBaseID: FBgn0260463
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_024303778.2
• Gene: ABLIM1 / 3983
• HGNCID: 78
• Length: 833
• Species: Homo sapiens
• Alignment Length: 907
• Identity: 274/907 - (30%)
• Similarity: 356/907 - (39%)
• Gaps: 358/907 - (39%)

  Fly    12 HPQTDKTRPIYPSTLGTELRTELGKTGQGKQKIYCAKCTKKCSGEVLRVADNHFHKACFQCCQCK 76
            |||.    |.:||.               |..|:|.||.:.|.||||||...|||..||.|..|.
Human    71 HPQD----PHHPSE---------------KPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCG 116

  Fly    77 KSLATGGFFTKDNAYYCIPDYQRLYGTKCANCQQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSG 141
            ..||.||||.|:..|.|..||||:|||:|..|.::||||||:.:|||||..||.|:.||:||..|
Human   117 CDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPG 181

  Fly   142 SKVTNTGKEVLCEQCVTGAPVSPSRQATGGGVSSPAPPAESPTRATAHQQHGSVISHKAHLKEDY 206
            .:||..|::.||:.|  ..|:|          |||                          ||..
Human   182 DRVTFNGRDCLCQLC--AQPMS----------SSP--------------------------KETT 208

  Fly   207 DPNDCAGCGELLKEGQALVALDRQWHVSCFRCKACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCA 271
            ..::|||||..:|.||||:|||:|||:.||:||:|..||.|||:.||..|||||.||..|||||.
Human   209 FSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCE 273

  Fly   272 YCSRFISGKVLQAGDNHHFHPTCARCTKCGDPFGDGEEMYLQGSAIWHPRC-------------- 322
            .|.:||:||||:|||. |:||:||||::|...|.:|||||||||.:|||.|
Human   274 ACHQFITGKVLEAGDK-HYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRLPN 337

  Fly   323 ------------------GPGPS------ESGIILNGGGGTSSVVGGASNGN------------- 350
                              |..||      .|..|.:..|  ||:.|  |.|:
Human   338 IRRSSSDFFYSKSLIRRTGRSPSLQPTRTSSESIYSRPG--SSIPG--SPGHTIYAKVDNEILDY 398

  Fly   351 --------------------------FTDTECDRMSSSALSEM-YIRSRTPSFNGSLYSSSRKHY 388
                                      :|....|:....:|.|. ...|.|||..|......|..:
Human   399 KDLAAIPKVKAIYDIERPDLITYEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIH 463

  Fly   389 RTVSPGLILREYGRPNAEDISRIYTYSYLTDAPHYLRKPIDPYDKTPLSP-HFHRPS-------- 444
            |:.|.|.|                      ::|.|.|....|  .|..|| |||||.
Human   464 RSTSQGSI----------------------NSPVYSRHSYTP--TTSRSPQHFHRPELLSPGVQR 504

  Fly   445 -SYATTASNAGSVAGSR--PPSRPHSRTRSAMKVLVDAIRSETP--------------RPKSP-- 490
             ||..|:|.:.:.:.||  ||.|.|         .:..|:...|              ||.:|
Human   505 LSYLRTSSLSPTHSDSRPNPPFRHH---------FIPHIKGNEPSSGRNSPLPYRPDSRPLTPTY 560

  Fly   491 ------------GMN--------------------NEEPIELSHYPAAKKPPPGEQPKIERDDFP 523
                        |:|                    :|:.|:.|.:|||:.|.|.|.||||.|.:|
Human   561 AQAPKHFHVPDQGINIYRKPPIYKQHAALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIETDHWP 625

  Fly   524 APP-YPYTDPERRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEEQQRLQREAEQLEKLNSGI 587
            .|| :....|:.:||.|       ..:::||              |..:|.|.:.|||.|||||:
Human   626 GPPSFAVVGPDMKRRSS-------GREEDDE--------------ELLRRRQLQEEQLMKLNSGL 669

  Fly   588 GSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASPSRNLDHQKPFYEDE 652
            |..|.|:..|                   ..|..:..|...||:|||
Human   670 GQLILKEEME-------------------KESRERSSLLASRYDSPI------------------ 697

  Fly   653 MFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGFKTTTLPYIRNGF----SSDFS-YGGLG 712
                             |:.|:  |.|.::...||||         |||.    |:||: |...|
Human   698 -----------------NSASH--IPSSKTASLPGYG---------RNGLHRPVSTDFAQYNSYG 734

  Fly   713 DKTHSTDLSCGKSEASVDSITEG--DRRALMGGDLPASSTYSGALSYHYPQAGLIRRSLPNM 772
            |                  ::.|  |.:.|..|.:||.....|.             |:|||
Human   735 D------------------VSGGVRDYQTLPDGHMPAMRMDRGV-------------SMPNM 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713	26/50 (52%)
		LIM2_abLIM	102..157	CDD:188714	28/54 (52%)
		LIM3_abLIM	211..262	CDD:188715	33/50 (66%)
		LIM4_abLIM	270..326	CDD:188716	34/87 (39%)
ABLIM1	XP_024303778.2	LIM1_abLIM	86..137	CDD:188713	26/50 (52%)
		LIM2_abLIM	142..197	CDD:188714	29/56 (52%)
		LIM3_abLIM	213..264	CDD:188715	33/50 (66%)
		LIM4_abLIM	272..327	CDD:188716	33/55 (60%)
		AbLIM_anchor	364..783	CDD:465046	124/556 (22%)
		VHP	798..833	CDD:128458