Protein Alignment Unc-115b and Ablim2

DIOPT Version :10

• Sequence 1: NP_731390.1
• Gene: Unc-115b / 41178
• FlyBaseID: FBgn0260463
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_036020916.1
• Gene: Ablim2 / 231148
• MGIID: 2385758
• Length: 720
• Species: Mus musculus
• Alignment Length: 771
• Identity: 227/771 - (29%)
• Similarity: 319/771 - (41%)
• Gaps: 188/771 - (24%)

  Fly    44 IYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANC 108
            |.|..|...|.||||||.:.:||..||.|..|...||.||||.:...:.|..||||||||:|.:|
Mouse    27 ILCNTCGNVCKGEVLRVQNKYFHIRCFVCKACGCDLAEGGFFVRQGEHICTRDYQRLYGTRCFSC 91

  Fly   109 QQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGV 173
            .:::||||||.:|||||..||.|:.|:.||..|.:||..|||.:|::|
Mouse    92 DRFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKECMCQKC----------------- 139

  Fly   174 SSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRC 238
               :||              :::.:.||:.:..  ..|.|||..:|.||||||||:.||:.||:|
Mouse   140 ---SPP--------------TLLGNSAHVAQGL--RSCGGCGLEIKNGQALVALDKHWHLGCFKC 185

  Fly   239 KACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDP 303
            |.|..:||.||:.||.:||||..|...||::|..|.::|:|:||:||:. |:||:||.|.:||..
Mouse   186 KTCGKLLNAEYISKDGLPYCEADYHSKFGIRCDGCEKYITGRVLEAGEK-HYHPSCALCVRCGQM 249

  Fly   304 FGDGEEMYLQGSAIWHPRCGPGP-SESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEM 367
            |.:|||||||||:||||.|.... :|....::     |||......|..   .|....:...||.
Mouse   250 FSEGEEMYLQGSSIWHPACRQAARTEDKSKMH-----SSVCSQPCPGTL---PCALQETRTSSES 306

  Fly   368 YIRSRTPSFNGSLYSSSRKHYRTVSPGLI-------------LREYGRPNAEDISRIYTYSYLTD 419
            .:.....|.:|   |.||..|..:...::             :....||:....|...::|.:.|
Mouse   307 IVSVPASSTSG---SPSRVIYAKLGDEILDYRDLAALPKNKAIYNIDRPDMISYSPYISHSAVGD 368

  Fly   420 APHYLRKP--IDPYDKTPLSPHFHRPSSYATTASNAGSVAGS------RPPSR-PHSRTRSAMKV 475
            ...|...|  :.|   ||.... ....||....:::.|.|||      .|.|| |...:|.|..|
Mouse   369 RQSYGESPQLLSP---TPTEGD-QDDRSYKQCRTSSPSSAGSVSLGHYTPTSRSPQHYSRPAGTV 429

  Fly   476 LVDAIR----SETPRPKSPGMNNEEPIELSHY-PAAKKPPPGEQ-PKIE-RDDFPAPPYPYTDPE 533
            .|....    |:.|.|.|        :...|| |..:....|.. |.:. ..|...|...|....
Mouse   430 SVGTSSCLSLSQHPSPTS--------VFRHHYIPYFRGSESGRSTPSLSVHSDSRPPSSTYQQAP 486

  Fly   534 RRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEEQQRLQREAEQLEKLNSGIGSAIAKDLKEH 598
            |.....||  ||      .:|:....|..| ::|...|      ..:.|| ||:.|.::..::|.
Mouse   487 RHFHVPDT--GV------KDNIYRKPPIYK-QHGPVAQ------SPMSKL-SGLVSVLSLVVQEA 535

  Fly   599 AKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASPSRNLDHQKPFYEDEMFDRSTSYRGS 663
            .:.::|..                        .||..|:.:|.||     .||..||:.:.
Mouse   536 GRSKRWAG------------------------LSPPQAAAARRLD-----VEDSSFDQDSR---- 567

  Fly   664 LGKSLGNAPSYNAIHSYRSPPKPGYGFKTTTLPYIRNGFSSDFSYGGLGDKTHSTDLSCGKSEAS 728
                                       |.||...::         |....:|:|.||.  ....|
Mouse   568 ---------------------------KKTTWLLLK---------GDADTRTNSPDLD--SQSLS 594

  Fly   729 VDSITEGDRRALMGGDLPASSTYSGALSYHYPQAGLIRRSLPNMSHSIISCANAKL 784
            :.|.|:.:....|.||    |.|| ...|..|.      :||......:...||.|
Mouse   595 LSSGTDQEPLQRMAGD----SLYS-RFPYSKPD------TLPGPRKDGLDLRNANL 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713	22/50 (44%)
		LIM2_abLIM	102..157	CDD:188714	28/54 (52%)
		LIM3_abLIM	211..262	CDD:188715	30/50 (60%)
		LIM4_abLIM	270..326	CDD:188716	31/55 (56%)
Ablim2	XP_036020916.1	LIM1_abLIM	29..80	CDD:188713	22/50 (44%)
		LIM2_abLIM	85..140	CDD:188714	29/74 (39%)
		LIM3_abLIM	158..209	CDD:188715	30/50 (60%)
		LIM4_abLIM	217..272	CDD:188716	31/55 (56%)
		AbLIM_anchor	300..670	CDD:465046	95/453 (21%)
		VHP	685..720	CDD:460493