DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-115b and DMTN

DIOPT Version :9

Sequence 1:	NP_731390.1	Gene:	Unc-115b / 41178	FlyBaseID:	FBgn0260463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001107607.1	Gene:	DMTN / 2039	HGNCID:	3382	Length:	405	Species:	Homo sapiens

Alignment Length:	467	Identity:	104/467 - (22%)
Similarity:	155/467 - (33%)	Gaps:	179/467 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 PRCGPG---PSESGIILNGGGGTSSVVGGASN-----------------------------GNFT 352
            |...||   ||....:   .|..||:|....|                             .:||
Human     8 PLTSPGSVSPSRDSSV---PGSPSSIVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFT 69

  Fly   353 -----DTECDRMSSSALSEMYIRSRTPSFNGSLYSSSRKHYRTVSPGLILREYGRPNAEDISRIY 412
                 ..|..|....:||.   :|.:|..:..:::.||      |||:|.:
Human    70 YSLLEHVELPRSRERSLSP---KSTSPPPSPEVWADSR------SPGIISQ-------------- 111

  Fly   413 TYSYLTDAPHYLRKPIDPYDKTPLSPHFHRPSSYATTASNAGSVAGSRPPSRPHSRTRSAMKVLV 477
                 ..||.....|     :|.| ||||.|.:             |||.|..:.:     ..:.
Human   112 -----ASAPRTTGTP-----RTSL-PHFHHPET-------------SRPDSNIYKK-----PPIY 147

  Fly   478 DAIRSETPRPKSPGMNNEEPIELSHYPAAKKPPPGEQPKIERDDFPAPP-YPYTDPERRRRYSDT 541
            ....|....|::..:..:..||.|.:|||:.|.|.:..|||.|.:|.|| ....:.|.|:|.:..
Human   148 KQRESVGGSPQTKHLIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASR 212

  Fly   542 YKGVPASDDEDENVENGKPNGKVKNGEEQQRL-QREAEQLEKLNSGIGSAIAKDLKEHAKYRKWK 605
            .......::||::           :|||.:.| :|:.|:|.|:.|.:|..|.|:..|.:
Human   213 RGAEEEEEEEDDD-----------SGEEMKALRERQREELSKVTSNLGKMILKEEMEKS------ 260

  Fly   606 QNNLDPRNASRTPSASKEPLYKLRYESPIGASPSRNLDHQKPFYEDEMFDRSTSYRGSLGKSLGN 670
                       .|...|                :|:|..:.||:..  ..:.||...||
Human   261 -----------LPIRRK----------------TRSLPDRTPFHTS--LHQGTSKSSSL------ 290

  Fly   671 APSYNAIHSYRSPPKPGYGFKTTTLPYIRNGFSSDFSYGGLGDKTHSTDLSCGKSEASVDSITEG 735
                           |.||  .|||..::   |::||..  |.:|.|..|..|          ||
Human   291 ---------------PAYG--RTTLSRLQ---STEFSPS--GSETGSPGLQNG----------EG 323

  Fly   736 DR-RALMGGDLP 746
            .| |...|..||
Human   324 QRGRMDRGNSLP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713
		LIM2_abLIM	102..157	CDD:188714
		LIM3_abLIM	211..262	CDD:188715
		LIM4_abLIM	270..326	CDD:188716	3/8 (38%)
DMTN	NP_001107607.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/24 (29%)
		AbLIM_anchor	8..369	CDD:406566	104/467 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..158		26/130 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..192		9/18 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..332		46/212 (22%)
		Interaction with RASGRF2. /evidence=ECO:0000269\|PubMed:11856323	224..308		31/155 (20%)
		VHP	370..405	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160039
Domainoid	1	1.000	89	1.000	Domainoid score	I7842
eggNOG	1	0.900	-	-		E1_KOG1044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24213
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.800