DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-115b and ablim3

DIOPT Version :9

Sequence 1:	NP_731390.1	Gene:	Unc-115b / 41178	FlyBaseID:	FBgn0260463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_004912894.1	Gene:	ablim3 / 100494921	XenbaseID:	XB-GENE-494311	Length:	664	Species:	Xenopus tropicalis

Alignment Length:	723	Identity:	225/723 - (31%)
Similarity:	313/723 - (43%)	Gaps:	193/723 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GKTGQGKQKIYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQR 99
            |.:|    .|.|.:|.:.|.|||:||..||||..||.|..|...||..|||.|:..|.|..|||:
Frog    15 GNSG----PIQCYRCGETCKGEVVRVQTNHFHIRCFTCQVCNCDLAQSGFFFKNGEYICTRDYQQ 75

  Fly   100 LYGTKCANCQQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSP 164
            ||||:|.:|:.::.|||:|.:|:|||.|||.||.|::||..|.|||..||:.:|:.|
Frog    76 LYGTRCDSCRDFITGEVISALGRTYHPKCFVCSICRKPFPIGDKVTFRGKDCVCQNC-------- 132

  Fly   165 SRQATGGGVSSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDR 229
                      |.:..::.|.:.     ||              |:.||||.|.:|:||:|:||::
Frog   133 ----------SHSLVSDKPIKI-----HG--------------PSHCAGCKEEIKQGQSLLALEK 168

  Fly   230 QWHVSCFRCKACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTC 294
            |||||||:|:.|..||.|||:.||.|||||..|...||:||..|:::|||:||:|| ..|:||||
Frog   169 QWHVSCFKCQTCGIVLTGEYISKDGVPYCESDYHAQFGIKCETCNKYISGRVLEAG-GKHYHPTC 232

  Fly   295 ARCTKCGDPFGDGEEMYLQGSAIWHPRCGPGP-SESGIILNGGGGTSSVVGGASNGNFTDTECDR 358
            |||.:|...|.:||||||.||.:|||.|.... :|..:.......||....|:|.|:.....|.:
Frog   233 ARCVRCQQMFSEGEEMYLTGSEVWHPICKQAARAEKKLKYRRASETSISPPGSSIGSPNRVICAK 297

  Fly   359 MSSSALSEMYIRSRTPSFNGSLYSSSRKHYRTVSPGLILRE-YGRPNAEDISRIYTY-------- 414
            :::..|:...: :..|... .:|:..|       |.||..| |.|..::::...|:|
Frog   298 VNNEILNYKDL-AALPKIK-PIYAVQR-------PDLISYEPYSRYTSDEMLERYSYGEDIYEGI 353

  Fly   415 ----------SYLTDAP----------------HYLRKPIDPYDKTPL--------SP------- 438
                      .|: |:|                ||.....|....:|.        ||
Frog   354 DLRQRRSSSPGYI-DSPLYRQHEVSLTMPRNPQHYYMSGTDSGRNSPFYSQIDVRCSPPTHYQVP 417

  Fly   439 -HFHRPSSYATTASNAGSVAGSRPPSRPHSRTRSAMKVLVDAIRSETPRPKSPGMNNEEPIELSH 502
             |||.|::       |.|....:||......|:|  |...|.::|....|..|.       ||.:
Frog   418 RHFHIPAA-------AESNIYRKPPIYKRHATKS--KTSEDLVQSSKYLPAYPH-------ELYY 466

  Fly   503 YPAAKKPPPGE----QPKIERDDFPAPPYPYTDPERRRRYSDTYKGVPASDDEDENVENGKPNGK 563
                  ||..|    .||:               .|.||||
Frog   467 ------PPESEFWMYSPKV---------------PRARRYS------------------------ 486

  Fly   564 VKNGEEQQRLQREAEQLEKLNSGIGSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKL 628
              :|.|:....|   .:.|:..|||..|   |||..|.|.:    .||....|:.:.|||.|:..
Frog   487 --SGGEEDGFDR---SMHKIQGGIGRMI---LKEEMKARSY----ADPWTPPRSSAGSKEALHTA 539

  Fly   629 RYESPIGASPSRNLDHQKPFY---EDEMFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGF 690
            .||:.:..||:|.       |   .|.:..:|.|........|...||....| |.|.....:|.
Frog   540 GYEASLNGSPTRR-------YLTDSDPLISKSASLPAYRRNGLHRPPSTELFH-YDSANAVNWGM 596

  Fly   691 KTTTL-PY 697
            :...: ||
Frog   597 REYKIYPY 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713	24/50 (48%)
		LIM2_abLIM	102..157	CDD:188714	27/54 (50%)
		LIM3_abLIM	211..262	CDD:188715	32/50 (64%)
		LIM4_abLIM	270..326	CDD:188716	31/55 (56%)
ablim3	XP_004912894.1	LIM1_abLIM	22..73	CDD:188713	24/50 (48%)
		LIM2_abLIM	78..133	CDD:188714	28/72 (39%)
		LIM3_abLIM	150..201	CDD:188715	32/50 (64%)
		LIM4_abLIM	209..264	CDD:188716	31/55 (56%)
		AbLIM_anchor	273..627	CDD:374416	92/423 (22%)
		VHP	629..664	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69175
Inparanoid	1	1.050	345	1.000	Inparanoid score	I2266
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001360
OrthoInspector	1	1.000	-	-		mtm9440
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X852
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.050