DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eca and tmed4

DIOPT Version :9

Sequence 1:	NP_788616.1	Gene:	eca / 41177	FlyBaseID:	FBgn0069242	Length:	216	Species:	Drosophila melanogaster
Sequence 2:	NP_001002134.1	Gene:	tmed4 / 415224	ZFINID:	ZDB-GENE-040625-140	Length:	220	Species:	Danio rerio

Alignment Length:	217	Identity:	144/217 - (66%)
Similarity:	173/217 - (79%)	Gaps:	10/217 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LILCV--------LHSACGLYFHISETERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGI 66
            |:.||        |..:..|||||.|||:||||||:||||.||..|:.:|:|.::..|:||:||:
Zfish     4 LVSCVGFLLLFVWLSPSQALYFHIGETEKKCFIEEIPDETMVIGRYRTQLWDKQAGSFLPSTPGL 68

  Fly    67 GMHVEVRDSDDKIVLSRVYSSQGRISFTSHTPGEHVICMFSNST--AWFSGAQLRVHLDIQVGEH 129
            |||||::|.:.|::|||.|.|.||.:|||||||||.||:.||||  |.|:|.:||||||||||||
Zfish    69 GMHVEIKDPETKVILSRQYGSDGRFTFTSHTPGEHQICLHSNSTKMALFAGGKLRVHLDIQVGEH 133

  Fly   130 AIDYAHVAQKEKLTELQLRIRQLLDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTVV 194
            ..:|..:|.|:||||||||:||||||||||.||||||||||||||.||||||.||||||:||||:
Zfish   134 TNNYPEIAAKDKLTELQLRVRQLLDQVEQIQKEQNYQRYREERFRMTSESTNQRVLWWSIAQTVI 198

  Fly   195 LVCMGFWQMRHLKSFFEAKKLV 216
            |:..|.|||:||||||||||||
Zfish   199 LIITGIWQMKHLKSFFEAKKLV 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eca	NP_788616.1	EMP24_GP25L	20..211	CDD:279450	133/192 (69%)
tmed4	NP_001002134.1	EMP24_GP25L	22..215	CDD:279450	133/192 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574549
Domainoid	1	1.000	291	1.000	Domainoid score	I1497
eggNOG	1	0.900	-	-		E1_KOG1690
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5308
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2657
OMA	1	1.010	-	-		QHG53581
OrthoDB	1	1.010	-	-		D1294924at2759
OrthoFinder	1	1.000	-	-		FOG0001070
OrthoInspector	1	1.000	-	-		mtm6359
orthoMCL	1	0.900	-	-		OOG6_102210
Panther	1	1.100	-	-	LDO	PTHR22811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1717
SonicParanoid	1	1.000	-	-		X178
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800