Protein Alignment eca and TMED3

DIOPT Version :10

• Sequence 1: NP_788616.1
• Gene: eca / 41177
• FlyBaseID: FBgn0069242
• Length: 216
• Species: Drosophila melanogaster
• Sequence 2: NP_031390.1
• Gene: TMED3 / 23423
• HGNCID: 28889
• Length: 217
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 68/321 - (21%)
• Similarity: 108/321 - (33%)
• Gaps: 97/321 - (30%)

  Fly   109 SWLQNITSETRATNC----KVYKLSIDEHGDF--AYPRPLEED---PMGCYKFPRITRSIRGQFP 164
            |||         ..|    .|::..:...||.  .|..||.:.   |...:.:|.:..|
Human    55 SWL---------VGCLFTIAVFQPPVQVLGDAGKVYIAPLRDTANLPCPLFLWPNMVLS------ 104

  Fly   165 DLRYYN------------FPNGNEGIESFPPSYRIPEWQAHAGWLGPRPFFRVKWGSPYPFQPSS 217
            ::|:|.            |.:|.:..|...|.|:           |.....|......|..|.|:
Human   105 EMRWYRPGHLPRTQAVHVFRDGQDRDEDLMPEYK-----------GRTALVRDAHKESYILQISN 158

  Fly   218 V-LESN---------GNRSRR-------ARFASKPVIPKSFRCDHMPHYHYVFPLNMPLYCREL- 264
            | ||..         ||.||.       |...|.|.|       |:..|...:   :.|.|:.:
Human   159 VRLEDRGLYQCQVWVGNSSREDNVTLQVAVLGSDPYI-------HVKGYDAGW---IELLCQSVG 213

  Fly   265 ------TVFNHNT------VSEYNG-DGSSFHRDASSSSLSNNQPEDLVIPFISRVALKVNQPFD 316
                  |.:...|      :||.:. |.:...|.|.||.:.:|...: |...|...||...:...
Human   214 WFPKPWTEWRDTTGRALLSLSEVHSLDENGLFRTAVSSRIRDNALGN-VSCTIHNEALGQEKTTA 277

  Fly   317 MFPGIP---TWFFQSMLNNYYLPI-GLLTFADFLLLAMYRCIELHLLGER----DGLVKDN 369
            |..|.|   :....::..:..||: |||......|:...:..:..||.|:    :.|::|:
Human   278 MIIGAPERGSLSSPAVALSVVLPVLGLLILLGIWLICKQKKSKEKLLYEQAMEVENLLEDH 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eca	NP_788616.1	EMP24_GP25L	20..211	CDD:426051	22/122 (18%)
TMED3	NP_031390.1	EMP24_GP25L	28..205	CDD:426051	38/185 (21%)
		COPI vesicle coat-binding. /evidence=ECO:0000255	204..217		2/15 (13%)
		COPII vesicle coat-binding. /evidence=ECO:0000255	204..205		0/3 (0%)