DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9444 and SLC15A2

DIOPT Version :10

Sequence 1:NP_649927.2 Gene:CG9444 / 41175 FlyBaseID:FBgn0037730 Length:557 Species:Drosophila melanogaster
Sequence 2:NP_066568.3 Gene:SLC15A2 / 6565 HGNCID:10921 Length:729 Species:Homo sapiens


Alignment Length:670 Identity:166/670 - (24%)
Similarity:271/670 - (40%) Gaps:210/670 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 PTIRMKYRYPRAVFFVLATKFFEAFAANGIRTVLALYLRDDLNFTESFSTVVLHIFNFFGQFCPI 123
            ||| ....||.::.|::..:|.|.|:..|::.||.||....|::.|..||.:.|.|:....|.||
Human    35 PTI-CGSNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPI 98

  Fly   124 IGAILADSYIGNVRTISGFSFIYAFGWLLLTLTSLPAMGLPMV--LLVSIALLFIAVGNGSIRAC 186
            :||.:|||::|..:||...|.:|..|.::.:|.:||.:|..:|  :|..|.|..||:|.|.|:.|
Human    99 LGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPC 163

  Fly   187 ITSLGALQFKLPEQSVHLAE---YFSFYYFVYYFGIFLSKILPPLVRANTQCFDKAECYPAVFGT 248
            :.:.|..||    :..|..|   |||.:|.....|..:|..:.|::|.:.|||.: :||...||.
Human   164 VAAFGGDQF----EEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFGE-DCYALAFGV 223

  Fly   249 LGAAFMMAWFIFLVGKWFYKSEKLSDDNILFKFCGCIKTALVEKWRRRK-STKRSNYWLHNAVVA 312
            .|...::|..:|.:|...| ::...:.||:.:...||..|:..:::.|. ...:..:||..|...
Human   224 PGLLMVIALVVFAMGSKIY-NKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEK 287

  Fly   313 YDMGFVNDVSRVLRISKLFIPLPFYFALLAQQDSSWTFQATQMNTTLMGVTIQPDQAKAVGPIFL 377
            |....:.||..:.|:..|:||||.::|||.||.|.||.||.:||..|....:||||.:.:.|:.:
Human   288 YPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLV 352

  Fly   378 FMLIPLWQYITVPLLR------------------------------------------------- 393
            .:.|||:.::...|:.                                                 
Human   353 LIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQ 417

  Fly   394 ---------------------------------------------------RYFNWELQPLHSV- 406
                                                               :|.|..|...||| 
Human   418 VLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQ 482

  Fly   407 -------------------------------------------------------TVG------- 409
                                                                   .||       
Human   483 EKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSA 547

  Fly   410 -------------------------GIFSAGAFFC--------AGALQERIKNSPPQTVNIAWQL 441
                                     |:...||.:.        .|....:|::.|...::|||||
Human   548 YRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQL 612

  Fly   442 PQFLLLMMGELLLSIPGLQFAFTQAPTSMKSVVTAAWFLNNAFGNLIVVLVTELGMLSSQMAEYF 506
            ||:.|:..||::.|:.||:|:::|||:|||||:.|||.|..|.||:||::|.:...| .|.||:.
Human   613 PQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGL-VQWAEFI 676

  Fly   507 FYAVVMLVCIILYALLAFDY 526
            .::.::||..::::::.:.|
Human   677 LFSCLLLVICLIFSIMGYYY 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9444NP_649927.2 MFS_SLC15A1_2_like 68..532 CDD:340905 162/661 (25%)
SLC15A2NP_066568.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34
2A1704 58..696 CDD:273343 157/644 (24%)
Extracellular domain (ECD). /evidence=ECO:0000250|UniProtKB:Q63424 402..611 16/208 (8%)
Blue background indicates that the domain is not in the aligned region.

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