DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9444 and Slc15a3

DIOPT Version :9

Sequence 1:	NP_001262431.1	Gene:	CG9444 / 41175	FlyBaseID:	FBgn0037730	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_647557.1	Gene:	Slc15a3 / 246239	RGDID:	628663	Length:	582	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	156/625 - (24%)
Similarity:	255/625 - (40%)	Gaps:	154/625 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AWRGERAQLKLAHRSSLPNYGFAPPTIRMKYRYPR-AVFFVLATKFFEAFAANGIRTVLALYLRD 98
            |.|.|:...:...|..|...|...|.     |:.| |...||..:..|..|..|:.:.|.||| :
  Rat     3 ALRAEQQPSRSGERQPLVAQGRWGPR-----RWRRTAAAAVLLVEMLERAAFFGVTSNLVLYL-N 61

  Fly    99 DLNFT---ESFSTVVLHIFNFFGQFCPIIGAILADSYIGNVRTISGFSFIY--AFGWLLLTLT-- 156
            .|||.   |..|...|..........| :|..|||.|:|....||....:|  |.|.||.|:|
  Rat    62 SLNFNWDGEHASRATLLFLGASYLLAP-VGGWLADVYLGRFLAISLSLLLYLAATGLLLTTITDD 125

  Fly   157 -------SLPAMGLP----------------MVLLVSIALLFIAVGNGSIRACITSLGALQFKLP 198
                   .:|.:.|.                ....:.:.||.:|:...|:|:.:||.||
  Rat   126 GRRSFCGEMPELPLKPACPSANCQGSWSSPYCATTLYLVLLLLALAASSVRSNLTSFGA------ 184

  Fly   199 EQSVHLA-----EYFSFYYFVYYFGIFLSKILPPLVRANTQCFDKAECYPAVFGTLGAAFMMAWF 258
            :|.:.|.     .:|:::|:....|..||.::...:..|....   :.|..:.|.:|.||    |
  Rat   185 DQVMDLGRDATRRFFNWFYWSINLGAILSLLVVAFIEQNISFL---QGYSIIVGLVGLAF----F 242

  Fly   259 IFLVGKWFY------KSEKLSDDNILFKFCGCIKTALVEKWRRRKSTK-----------RSNYWL 306
            |||:....:      .|:..|..|:.|:.| |...    :|.||.|::           |||.
  Rat   243 IFLIATPVFITKPPTGSQVSSMLNLAFQNC-CPGW----QWWRRPSSRNSEGAHLLPDQRSNQ-- 300

  Fly   307 HNAVVAYDMGFVNDVSRVLRISKLFIPLPFYFALLAQQDSSWTFQA----------TQMNTTLMG 361
            .......||.....:.:||.:....:|   |:.:..|..|::..|.          |..|.:|
  Rat   301 PGPSPQEDMANFQVLLKVLPVMVTLVP---YWMVYFQMQSTYVLQGLHLHIPNIFRTNPNISL-- 360

  Fly   362 VTIQPDQAKAVGP---------IFLFMLIPLWQYITVPLLRRYFNWELQP--LHSVTVGGIFSAG 415
             .::.|.:....|         ..:.:|:|:..::..|||.|   .:|.|  |..:.:|..|...
  Rat   361 -PLRSDSSNYRIPEAWLLLANVAVILILVPVKDHLIDPLLLR---CKLLPSALQKMALGMFFGFT 421

  Fly   416 AFFCAGALQ-ERIK-----NSPPQTV----------NIAWQLPQFLLLMMGELLLSIPGLQFAFT 464
            :...||.|: ||::     .:.||.:          :|.||:||:||:.:.|:..|||||:||::
  Rat   422 SIIVAGVLEKERLQYIAANQTVPQLIGKDLYYAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYS 486

  Fly   465 QAPTSMKSVVTAAWFLNNAFGNL----IVVLVT----------ELGMLSS-QMAEYFF-YAVVML 513
            :||.||:..:...:|..:..|:|    :|.|::          :.|.::: :|..||| .|.:..
  Rat   487 EAPRSMQGAIMGIFFCLSGVGSLLGSGLVALLSLPGGWMYCPKDFGNINNCRMDLYFFLLAGIQA 551

  Fly   514 VCIILYALLAFDYTLQERKAGMYVRMDSEAEDRDVPSTSR 553
            |..:|:..:|..|   ||     .|.|.::::    ||||
  Rat   552 VTAVLFLWIAGRY---ER-----TRQDPDSQN----STSR 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9444	NP_001262431.1	PTR2	68..524	CDD:225646	138/561 (25%)
		MFS	68..>190	CDD:304372	41/152 (27%)
		MFS	137..488	CDD:304372	104/440 (24%)
Slc15a3	NP_647557.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/16 (25%)
		PTR2	41..572	CDD:225646	140/569 (25%)
		MFS	177..521	CDD:304372	90/372 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3104
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D365203at2759
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760