DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and ECEL1

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	716	Identity:	186/716 - (25%)
Similarity:	312/716 - (43%)	Gaps:	119/716 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTY-TLIDITEQLLGRMDL 118
            |.|:.:.::.|::||::||.:|||.:  |:..||          ..:|| |:..|.||...|:..
Human   109 ARFLAANLDASIDPCQDFYSFACGGWLRRHAIPD----------DKLTYGTIAAIGEQNEERLRR 163

  Fly   119 AEALNVSSELAVAQR----FYNACLGANLHPFNAADP-AYLSLIRSIGGFPAVDGDAWKASNFNW 178
            ..|.........|||    |:.:||  ::.......| ..|.:|...||:.....:........|
Human   164 LLARPGGGPGGAAQRKVRAFFRSCL--DMREIERLGPRPMLEVIEDCGGWDLGGAEERPGVAARW 226

  Fly   179 -INMSAHLAN--YGANGLIRETLQL------RYPF---EPYTKLPELGFDHIIVHEENISRNTTR 231
             :|...:.|.  |.|..|...|:.|      ||..   :....|||   ..:.:.::..|.....
Human   227 DLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPE---RTLYLAQDEDSEKILA 288

  Fly   232 AFRLNEERMHGYLRAFGLPED-----RIREAIAGVFAFWRDALEIPPQCEVFDPY------RIKR 285
            |:|:..||:...|.|..:.:.     ::.:.:|.:.....|.|    :.:|...|      ::::
Human   289 AYRVFMERVLSLLGADAVEQKAQEILQVEQQLANITVSEHDDL----RRDVSSMYNKVTLGQLQK 349

  Fly   286 VFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKV---------------CARHRKAVANYLAMKL 335
            :.|      ::.|..|  .:::|.:.:..|.:.|               ...|| .:.|||..::
Human   350 ITP------HLRWKWL--LDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHR-VLHNYLVWRV 405

  Fly   336 LYRFDPKLKAPRYQ---------------RNYCSVTLYQSMR---FLFNKLYMANNFSEAKRLEM 382
            :......|..|..:               :....|.|.|:.|   .....|::..:||.|.:.::
Human   406 VVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKV 470

  Fly   383 SEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKVIEDR 447
            .::|.:::..|.:.||:.||:|||:||.|..|...:...:| :.|..|....:.:....:|.|..
Human   471 QQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVG-YPDFLLKPDAVDKEYEFEVHEKT 534

  Fly   448 YAETNINLQHLVVQINRFSSRHFQELTNDT---KPQKILTGLQVGAGYYTPD-NSINVMAGVVEP 508
            |.:..:|.....:|::....|  ||:...|   .||.:       ..||.|: |.:...||:::|
Human   535 YFKNILNSIRFSIQLSVKKIR--QEVDKSTWLLPPQAL-------NAYYLPNKNQMVFPAGILQP 590

  Fly   509 PIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYG 573
            .:|....|.||.:|.:|.|:||||.||:|.....:|.:|::....:|.|......:|||.:..|.
Human   591 TLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYD 655

  Fly   574 KYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSH-RQQLLEHPGQERISDAMPGLDLTPEQL 637
            .:.|  .::|||||.||.|||||..||:.|..||:.. |:...|||        :|.|..|.:||
Human   656 NFTV--YNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHGPEHP--------LPRLKYTHDQL 710

  Fly   638 FFLGFAQLFC-SHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRL 701
            ||:.|||.:| ....:..|.:.|:|.|..:.:||||.:|..|:|..|::|...|.|.|..| |.:
Human   711 FFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHK-CSV 774

  Fly   702 W 702
            |
Human   775 W 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	181/701 (26%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	181/701 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850