Protein Alignment Nepl12 and Ece1

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_006239337.1
• Gene: Ece1 / 94204
• RGDID: 620293
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 724
• Identity: 202/724 - (27%)
• Similarity: 312/724 - (43%)
• Gaps: 153/724 - (21%)

  Fly    64 MNQSVEPCENFYEYACGNY--RNVKPDRYSP-GSRSNLGDVTYTLIDITEQLLGRMDLAEALNVS 125
            |:.:|:||::|:.||||.:  .|..||.:|. |:.|||.:....:|   :.||..    ...:.|
  Rat   114 MDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAII---KHLLEN----STASAS 171

  Fly   126 SELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGA 190
            .....||.:|.||:.........|.| .:.||..:||: .:.| .|...||
  Rat   172 EAEKKAQVYYRACMNETRIEELRAKP-LMELIEKLGGW-NITG-PWAKDNF-------------- 219

  Fly   191 NGLIRETLQL---RYPFEPYTKLPELGFDHIIVHEENISRNT-----------TRAFRL----NE 237
                ::|||:   .|...|:..:      ::....:|.:.|.           :|.:.|    ||
  Rat   220 ----QDTLQVVTAHYRTSPFFSV------YVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENE 274

  Fly   238 ERMHGYLRAF--------GLPEDRIREAIAGVFAF-------------WRD---------ALE-- 270
            :.:.|||...        |..||.||..:..:..|             .||         |.|
  Rat   275 KVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQ 339

  Fly   271 --------IPPQCEVFDPYRIKRVFP----QSEYYYNISWSGLHSTNKLFCDFYYV--------- 314
                    :|....:|.|..|....|    ..||...:| :.::||:|...:.|.:
  Rat   340 TLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVS-TLINSTDKCLLNNYMMWNLVRKTSS 403

  Fly   315 ELDKVCARHRKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKR 379
            .||:   |.:.|...:  |:::|. ..|...||::  :|......::.|....:::...|:|..:
  Rat   404 FLDQ---RFQDADEKF--MEVMYG-TKKTCLPRWK--FCVSDTENNLGFALGPMFVKATFAEDSK 460

  Fly   380 LEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDALSDRIIREINSL 441
            ...||::.|::|:..::|....|:|.::|..|..|...|...||   ...|....|::   .|..
  Rat   461 NIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKV---FNDY 522

  Fly   442 KVIEDRYAETNINLQHLVVQINRFSSRHFQELTND------TKPQKILTGLQVGAGYYTP-DNSI 499
            ..:.|.|.|.       .::...||.|    :|.|      .:.|..:|...|.| ||:| .|.|
  Rat   523 TAVPDLYFEN-------AMRFFNFSWR----VTADQLRKAPNRDQWSMTPPMVNA-YYSPTKNEI 575

  Fly   500 NVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDR 564
            ...||:::.|.|.|..|.:|.||.:|.:|||||.|.||.....:|.:|::.......|.:|.:.:
  Rat   576 VFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQ 640

  Fly   565 AECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPG 629
            .||.:..|..|.|.  ...|||:.||.||||||.||:.|..||    |..::..|.|:|   :|.
  Rat   641 TECMVQQYNNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAY----QNWVKKNGAEQI---LPT 696

  Fly   630 LDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMR 693
            |.||..|||||||||::||....|...:|| :|.|:..:|||:|.||||::|...:.|.:||.|.
  Rat   697 LGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMN 761

  Fly   694 PGAKTCRLW 702
            |..| |.:|
  Rat   762 PRHK-CEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	199/716 (28%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	201/722 (28%)
		M13	118..767	CDD:189000	199/716 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850