Protein Alignment Nepl12 and MMEL1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 216/807 - (26%)
• Similarity: 351/807 - (43%)
• Gaps: 171/807 - (21%)

  Fly    11 LMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEY-QLQEYAEFMK------------- 61
            |:||.::|.|.|.   |..::    .:|..|....|.|:.. .|||...|:|
Human    29 LLLLLLLVTAALV---ALGVL----YADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVS 86

  Fly    62 ----------------SYMNQSVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDI 108
                            ..|:.:.|||::||::|||.:  |:|.|:   ..||.::.||   |.|.
Human    87 EVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPE---TNSRYSIFDV---LRDE 145

  Fly   109 TEQLLGRMDLAEALNVSSELAV--AQRFYNACLGANLHPFNAADPAYLSLIRSIGGFP-AVD--- 167
            .|.:|  ..:.|........||  |:..|.:|:..::.....:.| .|.::..:||:| |:|
Human   146 LEVIL--KAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQP-LLDILEVVGGWPVAMDRWN 207

  Fly   168 ---GDAWKA--------SNFN---------W---INMSAHLA----------------NYGANGL 193
               |..|:.        |.||         |   .|.|.|:.                |.|:|..
Human   208 ETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRK 272

  Fly   194 IRETLQLRYPFEPYTKLPE---LGFDHIIVHEE-----NISRNTTRAFRLNEERMHGYLRAF--- 247
            :||. .|::.....|.|.|   |..|..:|.|:     .:.....:|....||| |..:..:
Human   273 VREA-YLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEER-HDVIALYHRM 335

  Fly   248 GLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTNKLFCDFY 312
            ||.|.:.:..:.|.  .|...::     .|....:||.:..:....|.|.:  |.:...:
Human   336 GLEELQSQFGLKGF--NWTLFIQ-----TVLSSVKIKLLPDEEVVVYGIPY--LQNLENI----- 386

  Fly   313 YVELDKVCARHRKAVANYLAMKLL-----------------YR---FDPKLKAPRYQRNYCSVTL 357
               :|...||   .:.|||..:|:                 ||   |...::..|::.  |...:
Human   387 ---IDTYSAR---TIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRE--CVGYV 443

  Fly   358 YQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRI 422
            ..:|......||:...|....:..:.|::.::|....:.|::..|:|.||:.:|..|...|:.:|
Human   444 NSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQI 508

  Fly   423 G--SFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTG 485
            |  .:..:.::.|:..|.::|...||.|.|.  :||:|.|.    :.|..::|.....|...:.|
Human   509 GHPDYILEEMNRRLDEEYSNLNFSEDLYFEN--SLQNLKVG----AQRSLRKLREKVDPNLWIIG 567

  Fly   486 LQVGAGYYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHM 549
            ..|...:|:|: |.|...||:::||.:.:..|.:|.||.:|.::|||:.||||.....||.||:|
Human   568 AAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNM 632

  Fly   550 ESLLSEISQQALEDRAECYMDYYGKYQ---VPEISRRVNGKTTLDENIADNSGLRQALTAYRSHR 611
            ....|..|.|...:::||.:..||.|.   ..|  :.|||..||.||||||.|:|||..||
Human   633 MDWWSNFSTQHFREQSECMIYQYGNYSWDLADE--QNVNGFNTLGENIADNGGVRQAYKAY---- 691

  Fly   612 QQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLS 675
            .:.:...|:::   .:||||||.|||||:.:||::|..|..|...:.: :|||:..::||||.|.
Human   692 LKWMAEGGKDQ---QLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQ 753

  Fly   676 NSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            |...|...::|:.|:.|.| .:.||:|
Human   754 NLAAFADTFHCARGTPMHP-KERCRVW 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	196/716 (27%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	195/714 (27%)