Protein Alignment Nepl12 and ece1

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001071260.1
• Gene: ece1 / 777750
• ZFINID: ZDB-GENE-061110-100
• Length: 752
• Species: Danio rerio
• Alignment Length: 726
• Identity: 179/726 - (24%)
• Similarity: 302/726 - (41%)
• Gaps: 157/726 - (21%)

  Fly    64 MNQSVEPCENFYEYACGNYRNVKP-----DRYSPGS---RSNLGDVTYTLIDITEQLLGRMDLAE 120
            :::||:||::||.:|||.:....|     .|:.|.|   ..|:..:...|.:.:.:.|.|.:
Zfish    97 LDRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKSLSRAE--- 158

  Fly   121 ALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHL 185
                    ..||.:|.||:..:......|.|.. .||...||: .:.| .|:..||..: :....
Zfish   159 --------QKAQWYYQACMNESKIEELGAKPLQ-DLINQTGGW-GLKG-PWEKDNFQEV-LRIVS 211

  Fly   186 ANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNT-------------TRAFRLNE 237
            ||:..:           ||  :|         :.|..::.|.|:             :|.:.||:
Zfish   212 ANFRTS-----------PF--FT---------VFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNK 254

  Fly   238 ERMHGYLRAF-----------GLPEDRIREAIAGVFAFWRDALEIP-PQCEVFDPYRIKRVFPQS 290
            .....||.|:           |..:|..::.:..:..|......|. ||.|..|..:|
Zfish   255 TANEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKI------- 312

  Fly   291 EYYYN------------ISWSGLHST--------NK----LFCDFYYVELDKVCARHRKAVA-NY 330
              ||.            |.|....|:        |.    ::...|..::.::.:...|:|. ||
Zfish   313 --YYKIQAKELATLAPAIDWMPFLSSVFAPVELNNSEPVVVYAKEYLQKVSELISNTNKSVLNNY 375

  Fly   331 LAMKLLYR----FDPKLK-----------------APRYQRNYCSVTLYQSMRFLFNKLYMANNF 374
            :.||::.:    .|.|.:                 .||::  .|......::.|....|::...|
Zfish   376 MIMKVVRKMVSILDQKFQDAEQRFLEVMYGTKKSCMPRWK--LCVSDTDSALGFALGALFVKATF 438

  Fly   375 SEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREIN 439
            ||..:..:.:||.|::.:...:|:...|:|.|::..|..|...|...:|..:.......:.:..|
Zfish   439 SEDSKAFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFN 503

  Fly   440 SLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTND------TKPQKILTGLQVGAGYYTP-DN 497
            ...|:.|.|.:..:|..:       ||:|    :|.|      .:.|..:|...|.| ||.| .|
Zfish   504 DFDVVSDLYFQNVMNYYN-------FSAR----VTADQLRKAPNRDQWSMTPPTVNA-YYNPTKN 556

  Fly   498 SINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALE 562
            .:.:.||:.:.|.|....|.::.||.:|.::||||.|.||.....:|.:|::.......|.:|.:
Zfish   557 EMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQ 621

  Fly   563 DRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAM 627
            .:.:|.::.|..|.:.  :..:|||.||.||||||.||..|..||    ...::..|:|.   ::
Zfish   622 HQTQCMVEQYSNYSIN--NEPLNGKHTLGENIADNGGLNAAYKAY----VNWIKKNGEEA---SL 677

  Fly   628 PGLDLTPEQLFFLGFAQLFCSHYEEEHYWKG-LSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSG 691
            |.|.:...||||:||||::||....|...:| ::|.|:..:|||:|.:|||.:|...:.|...|.
Zfish   678 PALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSP 742

  Fly   692 MRPGAKTCRLW 702
            |.|..| |.||
Zfish   743 MNPKRK-CELW 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	175/718 (24%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	177/724 (24%)
		M13	101..750	CDD:189000	175/718 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950