Protein Alignment Nepl12 and Ecel1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_063123735.1
• Gene: Ecel1 / 60417
• RGDID: 61806
• Length: 792
• Species: Rattus norvegicus
• Alignment Length: 682
• Identity: 169/682 - (24%)
• Similarity: 295/682 - (43%)
• Gaps: 117/682 - (17%)

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTY-TLIDITEQLLGRMDL 118
            |.|:.:.::.|::||::||.:|||.:  |:..||          ..:|| |:..|.||...|:..
  Rat   110 ARFLSANLDASIDPCQDFYSFACGGWLRRHAIPD----------DKLTYGTIAAIGEQNEERLRR 164

  Fly   119 AEALNVSSELAVAQR----FYNACLGANLHPFNAADP-AYLSLIRSIGGFPAVDGDAWKASNFNW 178
            ..|.........|||    |:.:||  ::.......| ..|.:|...||:. :.|.|.:.....|
  Rat   165 LLARPTGGPGGAAQRKVRAFFRSCL--DMREIERLGPRPMLEVIEDCGGWD-LGGAADRPGAARW 226

  Fly   179 -INMSAHLAN--YGANGLIRETLQL------RYPF---EPYTKLPELGFDHIIVHEENISRNTTR 231
             :|...:.|.  |.|..|...|:.|      ||..   :....|||   ..:.:.::..|.....
  Rat   227 DLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPE---RTLYLAQDEESEKVLA 288

  Fly   232 AFRLNEERMHGYLRAFGLPED-----RIREAIAGVFAFWRDALEIPPQCEVFDPY------RIKR 285
            |:::..||:...|.|..:.:.     ::.:.:|.:.....|.|    :.:|...|      ::::
  Rat   289 AYKVFMERLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDL----RRDVSSVYNKVTLGQLQK 349

  Fly   286 VFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVC--------------ARHRKAVANYLAMKLL 336
            :.|      ::.|..|  .:::|.:.:..|.:.|.              :..|:.:.|||..:::
  Rat   350 ITP------HLQWKWL--LDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVV 406

  Fly   337 YRFDPKLKAPRYQ---------------RNYCSVTLYQSMR---FLFNKLYMANNFSEAKRLEMS 383
            ......|..|..:               :....|.|.|:.|   .....|::..:||.|.:.::.
  Rat   407 VVLSEHLSPPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQ 471

  Fly   384 EMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKVIEDRY 448
            ::|.:::..|.:.||:.||:||:::|.|..|...:...:| :.|..|....:.:....:|.|..|
  Rat   472 QLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVG-YPDFLLKPEAVDKEYEFEVHEKTY 535

  Fly   449 AETNINLQHLVVQINRFSSRHFQELTNDT---KPQKILTGLQVGAGYYTPD-NSINVMAGVVEPP 509
            .:..:|.....:|::....|  ||:...|   .||.:       ..||.|: |.:...||:::|.
  Rat   536 FKNILNSIRFSIQLSVKKIR--QEVDKSTWLLPPQAL-------NAYYLPNKNQMVFPAGILQPT 591

  Fly   510 IYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGK 574
            :|....|.||.:|.:|.|:||||.||:|.....:|.:|::....:|.|......:|||.:..|..
  Rat   592 LYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLHKAECIVRLYDN 656

  Fly   575 YQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSH-RQQLLEHPGQERISDAMPGLDLTPEQLF 638
            :.|  .::|||||.||.|||||..||:.|..||:.. |:...|||        :..|..|..|||
  Rat   657 FTV--YNQRVNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEHP--------LHRLKYTHNQLF 711

  Fly   639 FLGFAQLFC-SHYEEEHYWKGLSDVHTFDQFR 669
            |:.|||.:| ....:..|.:.|:|.|..:.:|
  Rat   712 FIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYR 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	166/671 (25%)
Ecel1	XP_063123735.1	None