Protein Alignment Nepl12 and mmel1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_017213856.1
• Gene: mmel1 / 560703
• ZFINID: ZDB-GENE-101112-2
• Length: 765
• Species: Danio rerio
• Alignment Length: 768
• Identity: 202/768 - (26%)
• Similarity: 351/768 - (45%)
• Gaps: 110/768 - (14%)

  Fly     8 LISLMLLWVIVAAVLTDCEARSLVDRSE------NSDSNGSSTNR--SAAEYQLQEYAEFMKSYM 64
            |:|..|..:||.......|..::.|.|:      ::|||..:|.:  :||...||.        |
Zfish    35 LMSCALAGLIVLYTSALRERFNINDSSKGLKYRSDADSNVCTTPQCVTAAARLLQN--------M 91

  Fly    65 NQSVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSE 127
            :.||:||:|||:||||.:  |:|.|:      .|:|..|...|.|..|.:|..:...|..:....
Zfish    92 DPSVDPCQNFYQYACGGWIERHVIPE------TSSLHSVFNILRDELEIVLKGVLEMENKDDREA 150

  Fly   128 LAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGANG 192
            ...|:..|::|:...|.....:.| .|.||.|||.:| |..:.|..::....::...||......
Zfish   151 FKKAKTLYSSCMNEILIEQRDSQP-LLRLIDSIGDWP-VASEVWNGTSEQTWSLEDTLAVLNGRY 213

  Fly   193 LIRETLQL----------RYPFEPYTKLPELGF---DHIIVHEENIS--RNTTRAFRLNEERMHG 242
            ..:..|::          ||..  :...|.||.   |:.: .:.|..  |.....|.::..|:..
Zfish   214 NKKAVLEMFVWPDDRDSSRYII--HVDQPALGMPSRDYYL-SDGNYKKVREAYLEFMVSMARIAR 275

  Fly   243 YLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRI---KRVFPQSEYYYNI---SWS-- 299
            ..|.....|:|:.|.::.|.....|........|..:...:   |....:::..:|:   :|:
Zfish   276 EDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDITVLYNKMTLREAQQTFNLNGFNWTRY 340

  Fly   300 --GLHSTNK----------LFCDFYYVELDKVCARH-RKAVANYLAMKLLY--------RFDPKL 343
              |:.|:..          ::|..|..:|.:|.::| .:.:.|||...|:.        ||  |.
Zfish   341 IQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHRTLQNYLVWMLIMDRVSSMSRRF--KD 403

  Fly   344 KAPRYQRNYCSVTLYQ------------SMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKA 396
            ....|::.....|:.:            :|......||:...||...:..:.|::::::::..:.
Zfish   404 VRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVRETFSGNSKRMVGELIKKIQEAYVET 468

  Fly   397 LEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKVIEDRYAETNIN----LQH 457
            ||:..|:|.:|:.:|..|...|..:||      ..|.|:.|.|  |.::..||..|.:    .::
Zfish   469 LEELSWMDEQSKVKAREKAMAISEQIG------YPDHILEEEN--KKLDQEYAHLNFSEENYFEN 525

  Fly   458 LVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRHLPISLKF 521
            ::..:...:.:..::|.....|...:.|..|...:|:.: |.|...||:::||.:......:|.|
Zfish   526 ILENLAASAQKGHKKLREPVDPDMWIIGAAVVNAFYSHNRNQIVFPAGILQPPFFSEKQLQALNF 590

  Fly   522 GTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEI-SRRVN 585
            |.:|.::|||:.||||.....||.:|:|.:..|..|.:..||:::|.::.||::..... .:.|:
Zfish   591 GGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQSKCMVEQYGRFSWKLAGGQNVS 655

  Fly   586 GKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHY 650
            |.|||.||||||.|:|||..||    .:.:|..|:|   ..:||||:..:|||||.|||::|...
Zfish   656 GITTLGENIADNGGVRQAYKAY----VKWVEREGEE---PRLPGLDMNHKQLFFLNFAQVWCGAC 713

  Fly   651 EEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ..|:..:.: :|.|:..::||||.|.|.|.|..|::|:.|:.|.|..| ||:|
Zfish   714 RPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEEK-CRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	181/696 (26%)
mmel1	XP_017213856.1	M13	95..763	CDD:341056	181/696 (26%)