DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and PHEX

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	753	Identity:	198/753 - (26%)
Similarity:	323/753 - (42%)	Gaps:	133/753 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SNGSSTNRSAAEYQLQ----EYAEFMKSYMNQSVEPCENFYEYACGNYRNVKP---DRYS----P 92
            |.|..:.::..||.|:    |.|..:.|.:|.||:||:||:.:||..:.:..|   |..|    |
Human    41 SQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYP 105

  Fly    93 GSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLI 157
            ..|.|   |...|.::.|:.:.|....||:.      .|:..|::|:.........|.|....|.
Human   106 WLRHN---VDLKLKELLEKSISRRRDTEAIQ------KAKILYSSCMNEKAIEKADAKPLLHILR 161

  Fly   158 RSIGGFPAVDGD-----AWKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFDH 217
            .|...:|.::.:     .|....|:.:...|......:|.:.     :|....|..|...   :|
Human   162 HSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVF-----IRLYVSPDDKASN---EH 218

  Fly   218 II----------VHEENISRNT-TRAFR---------------LNEER----MHGYLR------A 246
            |:          |.|:.:..:| .:::|               .|..|    |...||      .
Human   219 ILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAE 283

  Fly   247 FGLP-EDRIREAIAGVFAFWRDALEIPPQCEVFD--PYRIKRVFPQSEYYY--NISWSGLHSTNK 306
            ..:| |:|..||:....    :..|:......||  .| ||:|.....|.:  :||    .|.|.
Human   284 IMIPHENRTSEAMYNKM----NISELSAMIPQFDWLGY-IKKVIDTRLYPHLKDIS----PSENV 339

  Fly   307 LF-CDFYYVELDKVCARHR-KAVANYLAMKLLYRFDPKLKAPRYQRNY----------------- 352
            :. ...|:.:|.::....| |.:||||..:::|...|.| :.|:|..:
Human   340 VVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNL-SRRFQYRWLEFSRVIQGTTTLLPQW 403

  Fly   353 --CSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALE-DADWLDAESRARALLK 414
              |...:..::.::..|:::...|.|.|:..|.|:|..:|.:....|| :.:|:||.::.:|..|
Human   404 DKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEK 468

  Fly   415 ESRIQPRIGSFQDDALSDRIIRE-INSLKVIEDRYAETNINLQHLVVQINRFSSR----HFQELT 474
            ...:..::| :.:..::|..:.| :.::|..|..|....:..:..:.|.:.|..|    ..:..|
Human   469 ARAVLAKVG-YPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFT 532

  Fly   475 NDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIY-QRHLPISLKFGTLGFIVGHELIHGFDT 538
            |.|         .|.|.|....|.|...||.::.|.: ....|.||.:|.:|.|||||..||||.
Human   533 NPT---------TVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDN 588

  Fly   539 TSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQA 603
            ....:|.||:::...|..|::..:::.:|.::.|..|...:....|.||.||.||||||.|||:|
Human   589 NGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREA 653

  Fly   604 LTAYR---SHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGLS-DVHT 664
            ..|||   :.|:|.||.|       .:||:..|..|||||.:|.:.|:.|..|...:.:. ..|:
Human   654 FRAYRKWINDRRQGLEEP-------LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHS 711

  Fly   665 FDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ..||||.|.:||.|:|..|:||...|.|..|..:||||
Human   712 PPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	184/716 (26%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	184/716 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920