DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and Nepl18

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	771	Identity:	190/771 - (24%)
Similarity:	311/771 - (40%)	Gaps:	165/771 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQ----LQEYAEFMKSYMNQSV 68
            :::..:||:.:...:....|:.       ||:.....:...::|.    :|.....||:.|...|
  Fly     1 MMTSRVLWLCLLVAIVPAMAKP-------SDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEV 58

  Fly    69 EPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGR--MDLAEALNVSSEL-AV 130
            .||::||.:||||:.     |::|...  ||||......:..:...|  ..|..|.::.||| ..
  Fly    59 SPCDDFYTHACGNWH-----RHNPAQL--LGDVMTDNFKLISKGFDRRLQRLLRANDLQSELEKK 116

  Fly   131 AQRFYNACLGANLHPFNAADPAYL----SLIRSIGGFPAVDGDAWKASNFNWINMSAHLAN-YGA 190
            .||||.:|   ||  .:..|..|.    ::||..|..||:.|..|.:|:|:|....|.:.: ||.
  Fly   117 MQRFYMSC---NL--VHRDDVHYKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGK 176

  Fly   191 NGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEE-----RMHGYLRAFGLP 250
                    |:....|....:.....:.:.:.:.:.....||...|.||     .:..|   |||.
  Fly   177 --------QIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQY---FGLS 230

  Fly   251 E-------------DRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVF-------------PQ 289
            .             :|...:.....|..:::|.:....::.:.|.....|             |:
  Fly   231 SSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEKYSDHLNFTEFLGLILGEENIPK 295

  Fly   290 SEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRK----AVANYLAMKLLYRF--DPKLKAPRY 348
            |.|.|:..:                 |||.....|.    ..|||:..|||..|  |.:   |:.
  Fly   296 SLYIYDEEY-----------------LDKALLTMRSTPLATQANYVLWKLLEDFLVDAQ---PKD 340

  Fly   349 QRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRK-------SLRKAL--EDADWLD 404
            ...:|:    :|.:..|.||   ...:..||....::..|:.|       ..|:.|  :..||:.
  Fly   341 MVKWCT----ESTKKYFGKL---AEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWIS 398

  Fly   405 AESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKVIEDRYAETNI-------NLQHLVVQI 462
            ..:|..|:.|..|:...|.|:.::.              .|:.|.|..|       |:|.|::..
  Fly   399 NATRTLAIEKLERMHLNINSYDEEN--------------FENVYGEVFIDRLNYVSNVQQLLIAK 449

  Fly   463 N-RFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPP-IYQRHLPISLKFGTLG 525
            . ||.:|..|..  |:.....|.|..  ..|...:|:|.:...:::|. .:....|.:||:.|||
  Fly   450 GIRFVARINQPA--DSVDATELLGFT--PAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLG 510

  Fly   526 FIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQ-----VPEISRRVN 585
            :::.||::||||.....:|.:|::.......|:...|:|.:|:...|.:||     :||...:
  Fly   511 YLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQ-- 573

  Fly   586 GKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHY 650
                 .|||||:.||:.|..||.....|..|...|.   :.|.||.....||||||:|||.|
  Fly   574 -----SENIADSGGLKLAYAAYELWLGQQSEEVLQR---ETMEGLPFNSRQLFFLGYAQLLC--- 627

  Fly   651 EEEHY----WKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ::..:    |...||.|...::||:|.|||.::|...:|||..:.|.|..| |.::
  Fly   628 DDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYK-CAIY 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	179/703 (25%)
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	181/709 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	179/702 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850