Protein Alignment Nepl12 and Nep5

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Alignment Length: 855
• Identity: 196/855 - (22%)
• Similarity: 328/855 - (38%)
• Gaps: 236/855 - (27%)

  Fly     6 LKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEP 70
            |.|:.::|:.:||.         ||..:..:|........|:||..   .||      |::..:|
  Fly   106 LALVIILLIAIIVI---------SLGLKKSSSICRSKECLRTAASL---IYA------MDEQTDP 152

  Fly    71 CENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV--AQR 133
            ||:||::.||.:.|..|...|..|.....:....::.:..:.| |.::.:    |...||  |:.
  Fly   153 CEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFL-RSNITK----SEPEAVGKAKT 212

  Fly   134 FYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGD-----------AWKASN--FNWINMSAHL 185
            .|.||:...|......:|....|:|.  |.|.:...           |.:|:|  :||:.....:
  Fly   213 MYRACMDTKLLDKRDLEPLINYLLRF--GLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSI 275

  Fly   186 ANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTR----------AFRLNEERM 240
            ..:....||                  :|||   |..:..:|...|          ||..|.:..
  Fly   276 KQHLTMDLI------------------IGFD---VFPDPFNRTINRIALGTPETDSAFPFNNDDS 319

  Fly   241 HGYLRAF---------------------GLPEDRIREAIAGVFAFW---RDALE-----IPPQCE 276
            |..||..                     ...|:..::...|:.|:.   |..:|     :.|...
  Fly   320 HKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVN 384

  Fly   277 -----------VFDPYRI-KRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRKAVA- 328
                       |....|: ::|....|...|::....:..:    |..|:.|..:..:..|.:|
  Fly   385 QEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD----DIVYITLQDLQNQTDKNIAP 445

  Fly   329 -------NYLAMKLLYRFDPKLKAPRYQRN------------YCSVTLYQ--------------- 359
                   .|  |:|:      ||..|:..|            ...:|..|
  Fly   446 KTLPIWVRY--MELI------LKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIE 502

  Fly   360 -----------------SMRFLFNK---------------LYMAN-----------------NFS 375
                             |||.|.::               ||.||                 :|:
  Fly   503 SYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFT 567

  Fly   376 EAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINS 440
            :.|..::..|:.::|:|..:.::...|:||.::.:.:.|.:.::..||          ....:.:
  Fly   568 KEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIG----------FPPWLRN 622

  Fly   441 LKVIEDRYAETNINLQ-HLVVQINRFSSRHFQ---ELTNDTKPQKI---LTGLQVGAGYYTPDNS 498
            ..|:...|....:|.. ||.   |.....|:|   :|....||:.|   .:...|.|.:....|:
  Fly   623 ASVLNAYYEGAEVNASTHLE---NLMDFVHWQMMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNA 684

  Fly   499 INVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALED 563
            |.|...:::.|.|...|. :|.:|::|.|:||||.||||.:...||..|:|....|..:.....:
  Fly   685 ITVPIAILQYPFYDLGLE-ALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVN 748

  Fly   564 RAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMP 628
            |.||:::.|.:|.:.:|...::|:.||.||||||.|:|:|..|||.:.:::    |:||  ..:|
  Fly   749 RTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEV----GRER--SKLP 807

  Fly   629 GLD-LTPEQLFFLGFAQLFCSHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGM 692
            ||: .:.|||||:.|..|:|..|........|:|.|...|.|:.|||||||:|...:.|:.|:.|
  Fly   808 GLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPM 872

  Fly   693 RPGAKTCRLW 702
            .|....||:|
  Fly   873 NPDQPKCRIW 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	179/789 (23%)
Nep5	NP_733186.2	M13	151..880	CDD:341056	179/788 (23%)