DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and MME

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	797	Identity:	191/797 - (23%)
Similarity:	327/797 - (41%)	Gaps:	175/797 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEP 70
            :.|..|:||..|:|..:.     :|....::.....|...:|||.         :...|:.:.||
Human    29 ISLSVLVLLLTIIAVTMI-----ALYATYDDGICKSSDCIKSAAR---------LIQNMDATTEP 79

  Fly    71 CENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV--A 131
            |.:|::||||.:  |||.|:   ..||....|:   |.|..|.:|  .|:.:.......:||  |
Human    80 CTDFFKYACGGWLKRNVIPE---TSSRYGNFDI---LRDELEVVL--KDVLQEPKTEDIVAVQKA 136

  Fly   132 QRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVD-------GDAWKA---------------- 173
            :..|.:|:..:.......:| .|.|:..|.|:|...       |.:|.|
Human   137 KALYRSCINESAIDSRGGEP-LLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVL 200

  Fly   174 -------SNFNWINMSAHLAN----------YGANGLIRETLQLRYPF--------EPYTKLPEL 213
                   .:.|.:|...|:..          |...|:.:|.......|        ....:||
Human   201 INLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLP-- 263

  Fly   214 GFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVF 278
                  :.|..::....:...|.:|    ...|...||||                        .
Human   264 ------IDENQLALEMNKVMELEKE----IANATAKPEDR------------------------N 294

  Fly   279 DPYRIKRVFPQSEYYYNIS-------WSGLHSTNKL----------------FCDFYYVELDKVC 320
            ||..:......::...|.|       :|.|:.||::                :...|..:|..:.
Human   295 DPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPIL 359

  Fly   321 ARH-RKAVANYLAMKLLYRFDPKL-KAPRYQRNYCSVTLY-----------------QSMRFLFN 366
            .:: .:.:.|.::.:.:......| :..:..||.....||                 .:|.....
Human   360 TKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVG 424

  Fly   367 KLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALS 431
            :||:...|:...:..:.:::.::|:...:.|:|..|:|||::.||..|...|:.||| :.||.:|
Human   425 RLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIG-YPDDIVS 488

  Fly   432 --DRIIREINSLKVIEDRYAETNINLQHLVVQINRFS-SRHFQELTNDTKPQKILTGLQVGAGYY 493
              :::..|...|...||.|.|.       ::|..:|| |:..::|.......:.::|..|...:|
Human   489 NDNKLNNEYLELNYKEDEYFEN-------IIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFY 546

  Fly   494 TPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEIS 557
            :.. |.|...||:::||.:......||.:|.:|.::|||:.||||.....|:.:|.:....::.|
Human   547 SSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQS 611

  Fly   558 QQALEDRAECYMDYYGKYQVPEI-SRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQE 621
            ....:::::|.:..||.:..... .:.:||..||.||||||.||.||..||    |..::..|:|
Human   612 ASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAY----QNYIKKNGEE 672

  Fly   622 RISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYN 685
            ::   :|||||..:|||||.|||::|..|..|:....: :|||:...||::|.|.||.:|..|::
Human   673 KL---LPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFH 734

  Fly   686 CSVGSGMRPGAKTCRLW 702
            |...|.|.| .|.||:|
Human   735 CRKNSYMNP-EKKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	176/731 (24%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	175/729 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850