DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and Ece2

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	206/792 - (26%)
Similarity:	334/792 - (42%)	Gaps:	174/792 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HESLKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQS 67
            |..|:|: |..|.:::||:|..|.....|....:...:...|     |..::...:.::| :::.
  Rat   203 HTQLELV-LAGLILVLAALLLGCLVALWVQYHRDPVHSTCIT-----EACIRVAGKILES-LDRG 260

  Fly    68 VEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV 130
            |.||::||:::||.:  ||..|...|..:..|      :|.|..:.:|..:......|.|||
  Rat   261 VSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFN------SLWDQNQAILKHLLENSTFNSSSE--- 316

  Fly   131 AQR----FYNAC--------LGA--------NLHPFNAADP----AYLSLIRSIGG-------FP 164
            |:|    ||.:|        |||        .:..:|...|    .::.:::::.|       |.
  Rat   317 AERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIGGWNITGPWDEDNFMEVLKAVAGTYRAAPFFT 381

  Fly   165 AVDGDAWKASNFNWINMSAH-----LANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEEN 224
            ...|...|:||.|.|.:...     ..:|..|....|.:...|    ...:.|||   :::..:.
  Rat   382 VYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAAY----LDYMVELG---MLLGGQP 439

  Fly   225 ISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQ 289
            .|   |||.......:...|....:|:|:.|:                                :
  Rat   440 TS---TRAQMQQVLELEIQLATITVPQDQRRD--------------------------------E 469

  Fly   290 SEYYYNISWSGLH----STNKL-FCDF-------------------YYVELDKVCARHRKAVA-N 329
            .:.|:.:|.|.|.    |.:.| |..|                   |..::.::..|...::. |
  Rat   470 EKIYHKMSISELQTLAPSMDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNN 534

  Fly   330 YLAMKLL--------YRFD-------------PKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANN 373
            ||...|:        .||:             .|...||:|.  |......::.|....|::...
  Rat   535 YLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQT--CISNTDDALGFALGSLFVKAT 597

  Fly   374 FSEAKRLEMSE-MVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIRE 437
            |....: |::| |:.|:|.:..:.||:..|:|.::|..|..|...|...|| |.|..|..|.:.:
  Rat   598 FDRQSK-EIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIG-FPDFILEPRELDD 660

  Fly   438 I-NSLKVIEDRYAETNINLQH-----LVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD 496
            : :..:|.||.:.:..:||.:     :..|:.:..||....:|..|          |.|.|....
  Rat   661 VYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQT----------VNAYYLPTK 715

  Fly   497 NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQAL 561
            |.|...||:::.|.|..:.|.:|.||.:|.::||||.|.||.....:|..|::.......|..|.
  Rat   716 NEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTAF 780

  Fly   562 EDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDA 626
            ::...|..:.|.:|||.  ..|:||..||.||||||.||:.|..||::   .|.:| |:|:   .
  Rat   781 QNHTACMEEQYNQYQVN--GERLNGLQTLGENIADNGGLKAAYNAYKA---WLRKH-GEEQ---P 836

  Fly   627 MPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGS 690
            :|.:.||..||||:||||::||....|...:|| :|.|:..:|||||.||||.||...:.|.|||
  Rat   837 LPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGS 901

  Fly   691 GMRPGAKTCRLW 702
            .|.|| :.|.:|
  Rat   902 PMNPG-QLCEVW 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	191/723 (26%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	189/727 (26%)
		M13	261..910	CDD:189000	191/723 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850