Protein Alignment Nepl12 and Ece2

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_038944493.2
• Gene: Ece2 / 408243
• RGDID: 1303039
• Length: 789
• Species: Rattus norvegicus
• Alignment Length: 734
• Identity: 182/734 - (24%)
• Similarity: 301/734 - (41%)
• Gaps: 174/734 - (23%)

  Fly     3 HESLKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQS 67
            |..|:|: |..|.:::||:|..|.....|....:...:...|     |..::...:.::| :::.
  Rat   134 HTQLELV-LAGLILVLAALLLGCLVALWVQYHRDPVHSTCIT-----EACIRVAGKILES-LDRG 191

  Fly    68 VEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTY-TLIDITEQLLGRMDLAEALNVSSELA 129
            |.||::||:::||.:  ||..|   |..||.|    |: :|.|..:.:|..:......|.|||
  Rat   192 VSPCQDFYQFSCGGWIRRNPLP---SGRSRWN----TFNSLWDQNQAILKHLLENSTFNSSSE-- 247

  Fly   130 VAQR----FYNAC--------LGA--------NLHPFNAADP----AYLSLIRSIGG-------F 163
             |:|    ||.:|        |||        .:..:|...|    .::.:::::.|       |
  Rat   248 -AERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIGGWNITGPWDEDNFMEVLKAVAGTYRAAPFF 311

  Fly   164 PAVDGDAWKASNFNWINMSAH-----LANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEE 223
            ....|...|:||.|.|.:...     ..:|..|....|.:...|    ...:.|||   :::..:
  Rat   312 TVYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAAY----LDYMVELG---MLLGGQ 369

  Fly   224 NISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFP 288
            ..|   |||.......:...|....:|:|:.|:
  Rat   370 PTS---TRAQMQQVLELEIQLATITVPQDQRRD-------------------------------- 399

  Fly   289 QSEYYYNISWSGLH----STNKL-FCDF-------------------YYVELDKVCARHRKAVA- 328
            :.:.|:.:|.|.|.    |.:.| |..|                   |..::.::..|...::.
  Rat   400 EEKIYHKMSISELQTLAPSMDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILN 464

  Fly   329 NYLAMKLL--------YRFD-------------PKLKAPRYQRNYCSVTLYQSMRFLFNKLYMAN 372
            |||...|:        .||:             .|...||:|.  |......::.|....|::..
  Rat   465 NYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQT--CISNTDDALGFALGSLFVKA 527

  Fly   373 NFSEAKRLEMSE-MVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIR 436
            .|....: |::| |:.|:|.:..:.||:..|:|.::|..|..|...|...|| |.|..|..|.:.
  Rat   528 TFDRQSK-EIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIG-FPDFILEPRELD 590

  Fly   437 EI-NSLKVIEDRYAETNINLQH-----LVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTP 495
            :: :..:|.||.:.:..:||.:     :..|:.:..||....:|..|          |.|.|...
  Rat   591 DVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQT----------VNAYYLPT 645

  Fly   496 DNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQA 560
            .|.|...||:::.|.|..:.|.:|.||.:|.::||||.|.||.....:|..|::.......|..|
  Rat   646 KNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTA 710

  Fly   561 LEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISD 625
            .::...|..:.|.:|||.  ..|:||..||.||||||.||:.|..||::   .|.:| |:|:
  Rat   711 FQNHTACMEEQYNQYQVN--GERLNGLQTLGENIADNGGLKAAYNAYKA---WLRKH-GEEQ--- 766

  Fly   626 AMPGLDLTPEQLFFLGFAQ 644
            .:|.:.||..||||:||||
  Rat   767 PLPAVGLTNHQLFFVGFAQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	169/669 (25%)
Ece2	XP_038944493.2	None