Protein Alignment Nepl12 and Nep2

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 735
• Identity: 185/735 - (25%)
• Similarity: 309/735 - (42%)
• Gaps: 156/735 - (21%)

  Fly    64 MNQSVEPCENFYEYACGNY---RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVS 125
            |...||||:||||:|||.|   .|:..|:.|..:.|.:.|      .:.|||   .|:..|....
  Fly   100 MKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISD------KLQEQL---KDIITAERPE 155

  Fly   126 SE---LAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLAN 187
            :|   ..:....|.||:...|......:| ...:...:||:|.:.||:|.|.: :|
  Fly   156 TEPKHFRLPNLLYKACMNKTLIETLGPEP-ITRVAERLGGWPLIKGDSWNADD-SW--------- 209

  Fly   188 YGANGLIRETLQLRYPFEPYTKLPELGF--DHIIVHEENIS-RNTTRAFRL-------------- 235
                     |.|     |...|....||  |:||.....:. :|:|:  ||
  Fly   210 ---------TWQ-----EQVKKFRTAGFSMDYIIDFSIGVDLQNSTK--RLIDLDQSSLALSREY 258

  Fly   236 -----NEERMHGYLR-------AFGLPED----------RIREAIAGVFAFW-----RDALEI-- 271
                 ||..:..|.:       .||...|          ....|:|.:  .|     |::.|:
  Fly   259 LVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANI--SWPNEKRRNSSELYN 321

  Fly   272 ---PPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTN----KLFCDFYYVELDKVCAR-HRKAVA 328
               |.|.:...|| ::.|    :|...:...||:...    .|....::.:|.|:.|: .::.:|
  Fly   322 LRTPAQLQAAYPY-VQWV----DYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIA 381

  Fly   329 NYLAMKLLYRFDPKLKAPRYQRNYCSVTL------------------------------YQSMRF 363
            ||:..: ::.|.....:..:::.......                              :.|:..
  Fly   382 NYMFWR-IHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGI 445

  Fly   364 LFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDD 428
            ....||:..:|.:..:....|||.|:|......|::.:|:||:::..|.||...:...|| :.|:
  Fly   446 SVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIG-YPDE 509

  Fly   429 AL-SDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRH-FQEL---TNDTKPQKILTGLQV 488
            .| ::::......|.:..|:|.|:.:.:       |.|.:.: |.:|   .|.|...:......|
  Fly   510 MLDNEKLAAYYAKLDIDPDKYFESFLGM-------NIFGTDYSFNKLRLPVNKTDWVRHARPAIV 567

  Fly   489 GAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLL 553
            .|.|.:.:|||...||:::...:....|..:.||.:|:::|||:.||||.....||..|::....
  Fly   568 NAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWW 632

  Fly   554 SEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHP 618
            ...:|:|...:|:|.::.||.|........:||..|..||||||.|::::..|||    :..|..
  Fly   633 HPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYR----RWAEKH 693

  Fly   619 GQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHY-WKGLSDVHTFDQFRVLGVLSNSEDFFH 682
            |.|.   .:||||.||||:|::...|.:|:.|.:|.. .:..:.||:..:|||||.|||.:||..
  Fly   694 GPEA---KLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAK 755

  Fly   683 AYNCSVGSGMRPGAKTCRLW 702
            .::|..||.|.|..| |.:|
  Fly   756 DFHCPEGSPMNPVQK-CEVW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	182/727 (25%)
Nep2	NP_001246914.1	M13	104..772	CDD:341056	182/727 (25%)