Protein Alignment Nepl12 and Nepl11

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Alignment Length: 749
• Identity: 145/749 - (19%)
• Similarity: 254/749 - (33%)
• Gaps: 223/749 - (29%)

  Fly    10 SLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENF 74
            :|.:||:...|...|...|                    .|.:|..::..::.|::.|.:||::|
  Fly     5 ALAVLWIAGIAYGQDDLLR--------------------VETELLSFSHNLEPYLDTSKQPCQDF 49

  Fly    75 YEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFYNAC- 138
            |.|.|.:..|:          |..|...:      :.||...|:|:.:::..:|.   .|:.:|
  Fly    50 YGYVCSHSANL----------SETGRQRF------QSLLKETDVAQLMDMELQLI---NFFKSCE 95

  Fly   139 LGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKAS-----NFNWINMSAHLANYGANGLIRETL 198
            .|..:.....:     .|.|..||:|:::.:...||     ...|:.:..:....||
  Fly    96 SGRGVEALKGS-----QLYRQSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGA-------- 147

  Fly   199 QLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFA 263
              .|.||....: :.....:::..:...|||.|.|   |:|:...|::||:.:.|.......|.:
  Fly   148 --PYFFETSVTM-QSNKRLVVLQPDGTRRNTLRKF---EQRVGEVLQSFGIEQSRAHVTALEVLS 206

  Fly   264 FWRDALEIPPQCEVFDPYR-----IKRVFPQSEYYYNISWSGLHSTNKLFCDFYYVEL------- 316
            ..|...:|.....|.|..:     .||:...:.....:.|.|           |:.:|
  Fly   207 LERSRRDIVKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDG-----------YFRKLLGGKTPQ 260

  Fly   317 --DKVCARHRKAVANYLAM-------KLL------YRFDPKLKAPRYQRNYCSVTLYQSMRFLFN 366
              |.:..:....:..|.|:       :||      |..| .:.|..:|               .:
  Fly   261 ASDTIVVKQLPRLVEYFALLQNTSMVRLLNWIWTDYLMD-IVDADCHQ---------------LS 309

  Fly   367 KLYMANNFSE------AKRLEMSEMVRELRKSLRKALEDADWLDAESR--ARALLKESRIQPRIG 423
            :.|..:.::.      |.|:|:::|..||.|:....|..:.|:|..||  :|..|.........|
  Fly   310 ETYAGDLYAHVVQRVTANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLNG 374

  Fly   424 SFQDDALSDRII-------REINSLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQK 481
            ..:.||....|:       |.:..|:    ::..|.....|...|:.|:
  Fly   375 DERLDAAYHSILLGRRSLYRNLEKLR----KFQRTRRLASHSAQQVRRY---------------- 419

  Fly   482 ILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGN 546
                    |..:.|   :|...|       |.:|...|.:..||......|:....::.:    .
  Fly   420 --------AQMFAP---VNAFLG-------QHNLSTPLNYLLLGEFFSRSLVAAGSSSRT----Q 462

  Fly   547 GHMESLLSE----ISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAY 607
            |...|..||    |.||.                   :.::.|....|...:|.    ||||:||
  Fly   463 GAWRSSDSERRFAIFQQC-------------------VGKQTNAIDLLLSLLAQ----RQALSAY 504

  Fly   608 RSHRQQLLEHPG-QERISD--AMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGLSDVHTFDQFR 669
               .|.|....| .||:..  |.....::.::|||:....:.|.           |::....|.|
  Fly   505 ---GQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTSLLVDCR-----------SELGALQQDR 555

  Fly   670 VLGV----LSNSEDFFHAYNCSVGSGMRPGAKTC 699
            ...|    |.||.:|..|:.|..|..:.|..:.|
  Fly   556 KRQVTHATLRNSPEFLEAFRCRPGDVLYPQDQRC 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	135/691 (20%)
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	134/687 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016748
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.910