DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and phex

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001307259.1	Gene:	phex / 386969	ZFINID:	ZDB-GENE-030103-2	Length:	745	Species:	Danio rerio

Alignment Length:	745	Identity:	199/745 - (26%)
Similarity:	319/745 - (42%)	Gaps:	155/745 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 EYAEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLG-------DVTYTLIDITEQL 112
            |.|..:.|.|:|||:||::||:||||.:....|   .|...|:.|       :|...|.::.||.
Zfish    59 EAAGSILSKMDQSVDPCDDFYQYACGGWLRENP---IPEDSSSYGIYPWLRQNVDLKLKELLEQP 120

  Fly   113 LGRMDLAEALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDA------W 171
            :...|: ||:..:..|      |.:|:..:......|:|...:|.:....:|.: |||      |
Zfish   121 VRSGDI-EAVKKAKVL------YASCMNESALEIEDANPLLKNLKQKEFRWPVL-GDALGSSSRW 177

  Fly   172 KASNFNWINMSAHLANYGANGLIRETLQLRYPFEP--------YTKLPELGFDHIIVHEENISRN 228
            ..|.||.:...|.:.:..:..::     :|....|        ..||.:....  :...|:...|
Zfish   178 VESQFNLLETLAQIRSQHSKSVL-----IRLFVAPDDKNSNQYIIKLDQASLS--LSSREDYITN 235

  Fly   229 TTRAFRLNEERMHGYLR-------AFGLPEDRIREAIAGVFAFWRDALEIPPQCE------VFDP 280
            ||.|....|    ..||       ..|..|......:..|..|.....:|....|      :::.
Zfish   236 TTEAQMYRE----ALLRLMVDVSVMLGASEQAAEAQMKSVLDFEMKLAQIVIPYENRTSENMYNK 296

  Fly   281 Y---RIKRVFPQSEYYYNISWSGLHST---NKLFCDF--------------YYVELDK-VCARHR 324
            |   :::|..|      :.:|.|....   .:|:.|.              |:.:|.| :.|...
Zfish   297 YSLSKLQRTVP------DFNWLGFVRAVIDTELYPDLKISSSEQVIVRAPQYFKDLFKLINATDT 355

  Fly   325 KAVANY------------LAMKLLYRF--------DPKLKAPRYQR--NYCSVTLYQSMRFLFNK 367
            :.||||            |:.:.|||:        ......||:.:  ||...||.    :...:
Zfish   356 RTVANYVIWRSVFSRITTLSRRFLYRYLDFARVTTGTTSLTPRWDKCVNYVENTLI----YAAGR 416

  Fly   368 LYMANNFSEAKRLEMSEMVRELRKSLRKALE-DADWLDAESRARALLKESRIQPRIGSFQDDALS 431
            |::..:|.|.|:..|.|::..:|.:....|| :.:|:|.|::.:|:.|...:.|::| :.|..|:
Zfish   417 LFVDKHFQEDKKHMMEELINGIRWAFIDILEKENEWMDEETKRKAIDKAHAVLPKVG-YPDFILN 480

  Fly   432 DRIIRE----------------INSLKVIEDRYAETNIN-LQHLVVQINRFSSRHFQELTNDTKP 479
            |..|.|                :.:||.|    |:::|. |:..|.:...|        ||.|
Zfish   481 DTYINEDIKRLAFTMTDYFGNVMQTLKFI----AQSDIGWLRKTVPRTEWF--------TNPT-- 531

  Fly   480 QKILTGLQVGAGYYTPDNSINVMAGVVEPPIY-QRHLPISLKFGTLGFIVGHELIHGFDTTSSYF 543
                   .|.|.|.:..|.|...||.::.|.: ..:.|.||.:|.:|.||||||.||||.....:
Zfish   532 -------TVNAFYSSSTNQIRFPAGELQKPFFWGLNYPRSLSYGAIGVIVGHELTHGFDNNGRKY 589

  Fly   544 DGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYR 608
            |.:|:::...|..|.....::.:|.:|.|..|...|....|.||.||.||||||.|:|::..|||
Zfish   590 DKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAENIADNGGIRESFRAYR 654

  Fly   609 SHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLG 672
            ...::  |..|.|  ...:||:.||..|||||.:|.:.|:.|..|.....: |..|:..::||:|
Zfish   655 RWVEK--ERGGVE--EPLLPGVGLTHNQLFFLSYAHVRCNAYRPEAARDQIQSGAHSPPKYRVIG 715

  Fly   673 VLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            .:||.|:|..|:||...|.|..||::||:|
Zfish   716 AMSNFEEFRKAFNCPETSIMNRGAESCRVW 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	190/728 (26%)
phex	NP_001307259.1	PepO	61..744	CDD:226118	196/740 (26%)
phex	NP_001307259.1	M13	72..743	CDD:189000	190/728 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920