DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and KEL

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	728	Identity:	162/728 - (22%)
Similarity:	281/728 - (38%)	Gaps:	179/728 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 NQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELA 129
            |.||.||.:|:.:|||..:..........:::.            .:|...:::..:.:..|...
Human   106 NTSVAPCTDFFSFACGRAKETNNSFQELATKNK------------NRLRRILEVQNSWHPGSGEE 158

  Fly   130 VAQRFYNACL------GANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANY 188
            .|.:|||:|:      .|...|..       .:|..:||: .:.| .|.:.||| ..:...::.|
Human   159 KAFQFYNSCMDTLAIEAAGTGPLR-------QVIEELGGW-RISG-KWTSLNFN-RTLRLLMSQY 213

  Fly   189 GANGLIRETLQLRYPFEPYTKL-----PE-------------------------------LGFDH 217
            |.....|..|. .:|..|:|.:     ||                               ||.|.
Human   214 GHFPFFRAYLG-PHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDP 277

  Fly   218 IIVHEE---NISRNTTRAFR----LNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQC 275
            ..|.|.   :|| .|:|.|:    |.:.|..|.|... :..|:::|....:  .|...|:
Human   278 SKVQEHSSLSIS-ITSRLFQFLRPLEQRRAQGKLFQM-VTIDQLKEMAPAI--DWLSCLQ----- 333

  Fly   276 EVFDPYRI----KRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRKAVANYLAMKLL 336
            ..|.|..:    ..|....||..|:|..                ::::..:.|..:.:::.:.|:
Human   334 ATFTPMSLSPSQSLVVHDVEYLKNMSQL----------------VEEMLLKQRDFLQSHMILGLV 382

  Fly   337 YRFDPKLKAPRYQRNYCSVTLYQSMRFLFNK--------------------------LYMANNFS 375
            ....|.|.:   |.......|.|.:|.|..:                          |::...|.
Human   383 VTLSPALDS---QFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFG 444

  Fly   376 EAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIR-EIN 439
            .:.|....::...:|.:|...|.:..|::.|::..|..|.:::|..:|: .:.||...:.| |.|
Human   445 PSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGA-SEWALKPELARQEYN 508

  Fly   440 SLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQ---KILTGLQVGAGYYTPDNSINV 501
            .:::       .:..||.::..:....:|..|... ...||   |: :...|.|.|...|:.:..
Human   509 DIQL-------GSSFLQSVLSCVRSLRARIVQSFL-QPHPQHRWKV-SPWDVNAYYSVSDHVVVF 564

  Fly   502 MAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLS----EISQQALE 562
            .||:::||.:....|.::.||..|.|:.|||:|.|            .:.||.    .....||:
Human   565 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF------------YQLLLPGGCLACDNHALQ 617

  Fly   563 DRAECYMDYYGKYQVPEISR-RVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDA 626
            :...|...:|..:.:|  || ..|...|..||.||..||..||.||   .::||.|.|:    ..
Human   618 EAHLCLKRHYAAFPLP--SRTSFNDSLTFLENAADVGGLAIALQAY---SKRLLRHHGE----TV 673

  Fly   627 MPGLDLTPEQLFFLGFAQLFC--SHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVG 689
            :|.|||:|:|:||..:||:.|  ...::.|      |.|:....||.|.||::..|...:.|:.|
Human   674 LPSLDLSPQQIFFRSYAQVMCRKPSPQDSH------DTHSPPHLRVHGPLSSTPAFARYFRCARG 732

  Fly   690 SGMRPGAKTCRLW 702
            :.:.|.:: |:||
Human   733 ALLNPSSR-CQLW 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	157/721 (22%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	160/726 (22%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	157/721 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.760