Protein Alignment Nepl12 and Nepl10

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 705
• Identity: 148/705 - (20%)
• Similarity: 249/705 - (35%)
• Gaps: 187/705 - (26%)

  Fly    64 MNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMD-LAEALNVSSE 127
            :|::..||.||:.:|||.:.:.  .:|..............:::..|..||..| ||..|
  Fly    36 LNRTTSPCTNFWNFACGRFSSA--SKYVDNFERVEDQFATAMVEFMESHLGENDTLAPRL----- 93

  Fly   128 LAVAQRFYNACL--GANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGA 190
            :...:::|.||.  ...||    .:|....|:.                  .||........||.
  Fly    94 IKQMRQYYKACKEDTRKLH----GNPRPEELVN------------------QWILHPKKFLVYGL 136

  Fly   191 NGL-------------IRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNE----- 237
            ||:             :|..:|||.| :|..:..:              |...:..||.|
  Fly   137 NGVFIDERVDVAANDSMRWVIQLRMP-DPADRYSD--------------RRVLQLMRLYEEAWYS 186

  Fly   238 -------ERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYN 295
                   |:||..       :|:.|.....|:. |.           |...|.:...|.|   :.
  Fly   187 MGVVKLVEKMHQL-------QDKYRAEYPVVYT-WS-----------FSELRQEIPIPHS---FF 229

  Fly   296 ISWSGLHSTNKLF---CDFYYVELDKVCARHRKAVAN-----YLAMK---LLYRFDPKLKAPRYQ 349
            |...|::.|.:|:   .:...||..:.|.|..:..|:     |:..:   |:...:|:.:.||..
  Fly   230 IELLGVNHTEELYHLTFEVSDVEYLRECFRCLRDFASEPKDTYIRARQYVLVEESEPRERNPRSC 294

  Fly   350 RNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAE-------- 406
            .::....|...|.:::::....|      |.|.:..|.|:..:|:.|.  ..:|||.
  Fly   295 IHHMRAYLPLGMNYIYDRFIYQN------REEDTSKVLEILSTLKAAF--GQYLDANRLQLTPNQ 351

  Fly   407 -SRARALLKESRIQPRIGS--------FQDDALSDRIIREINSLKVIEDRYA-ETNINLQHLVVQ 461
             :..||.|:  .||.:||:        |.::..........|.|..:.:.:| .|.:....|:.:
  Fly   352 LAYVRAKLE--GIQIKIGNLPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLAR 414

  Fly   462 INRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGF 526
            .:|...||:....|..|       .:....|....|:|.|....::.|::........:...||.
  Fly   415 NSRVDLRHYYVNDNVRK-------ARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGA 472

  Fly   527 IVGHELIHGFDTTSSYFDGNGHMESLLSEISQ-QALEDRAECYMDYYGKYQVPEISRRVNGKTTL 590
            ::|||:.|.|:.....||..|:...:..||.: :...|..:|      ..:.|.:|        |
  Fly   473 VLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKC------AEEQPFVS--------L 523

  Fly   591 DENIADNSGLRQALTAY--RSHRQQLLEHP----GQERISDAMPGLDLTPEQLFFLGFAQLFCSH 649
            .|.:||.:||:.|..|:  .:|..:..|:.    .||          .|..|||.|.:||.||.
  Fly   524 KERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQE----------FTAPQLFHLSYAQFFCG- 577

  Fly   650 YEEEHYWKGLSDV--HTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
                    .|..|  |..|..||...:.|...|.:.:||....     :..|.:|
  Fly   578 --------SLPPVIAHDRDDERVNVSVGNLRQFAYDFNCETSP-----SSVCEMW 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	145/697 (21%)
Nepl10	NP_610787.1	GluZincin	41..608	CDD:301352	143/682 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920