DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and Nepl9

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	157/799 - (19%)
Similarity:	251/799 - (31%)	Gaps:	308/799 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RSENSDSNGSSTNRSAAEYQL-------QEYAEFMKSYM-------NQSVEPCENFYEYACGNYR 83
            ||:|.:.:.|.|     |.::       |.::...||.:       |.|::||::||.:||||:.
  Fly    17 RSQNGEDSDSDT-----EVEMDSEVESGQFFSHLYKSNLQQLVKIKNDSMDPCDDFYAHACGNFD 76

  Fly    84 NVK---------PDRYSPGSRSN-----LGDVTYTLIDITEQLLGRMDLAEALNVSSELAVA--- 131
            ..|         |..|:...|.|     :|:.......:..||.......|..||.:...:.
  Fly    77 QTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGRLISQLYTECRKREERNVFTPTRLTSHW 141

  Fly   132 QRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKA----SNFNWINMSAHLANYGANG 192
            :|..:..      ||.|.....||      .:|.:. ..|:.    ...|||.:||.||.:|...
  Fly   142 ERMLDEI------PFLARHKEVLS------SWPFLK-HQWERRRLYGQLNWIVLSAQLAAHGLPT 193

  Fly   193 LIR-----ETLQLRYPFEPYTKLP---------EL-----GFDH----IIVHE------------ 222
            |:.     :|:.:    .|..:||         .|     |..|    ||.||
  Fly   194 LLHIYFALDTIYV----SPMEELPCPSIADFQSSLSDVLEGRHHQVSRIISHEMRVLCREMRGEL 254

  Fly   223 -------ENISRNTTR---------------------AFRLNEERMHGYLRAFGLPEDRIREA-- 257
                   :|...||:|                     |...:|||:.| .|.|.|..::|.:|
  Fly   255 PLVRSLSQNTRTNTSRPGEEQLLLDENTMDYFQQYFAALNFSEERLVG-ARKFPLDVEKITQAWE 318

  Fly   258 --------IAGVFAFW--RDALEIPPQCEVFDPYRIKRVFPQ---SEYYYNISWSGLHSTNKLFC 309
                    |...:..|  |:.|..|      |.||:...|.:   :||:   .|
  Fly   319 VLRHTETRIVYNYVMWQAREQLRYP------DCYRVSEEFERLLHAEYW---QW----------- 363

  Fly   310 DFYYVELDKVCARH---RKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMA 371
                    .|..||   ..|:|:|           :|...|:|:
  Fly   364 --------HVLRRHLSREVALASY-----------QLHTTRFQK--------------------- 388

  Fly   372 NNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIR 436
                             ||:|   .|...||......|....||.::...:.:..::.|:   |.
  Fly   389 -----------------LRRS---KLSRRDWYGHLWPASVEKKELQVARILQNHAENYLN---IT 430

  Fly   437 EINSLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTP---DNS 498
            |:|.             |.:.|.::.|.|.:...           ||...|:...:.:|   :..
  Fly   431 ELNE-------------NYEGLKLEKNSFYANLL-----------ILRRAQLRHSFVSPYVDEED 471

  Fly   499 INVMAGVVEPPIYQRH----LPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGH---MESLLSEI 556
            :|      :|..:.||    :.:||...|..:...|.| ..:..:....|.:||   |:.|..:.
  Fly   472 VN------QPAYFLRHFLHFVLLSLHRPTYHYYATHGL-ELWRESRLLLDTDGHYTAMDCLERQS 529

  Fly   557 SQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEH---- 617
            .|......|..|.. .|.:::.||                       ...|||.:..|.::
  Fly   530 FQHYDAKLAPIYRP-LGSHEIAEI-----------------------FQFYRSFQYSLTDYHFWL 570

  Fly   618 PGQERISDA----MPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGLSDVHTFDQFRVLGVLSNSE 678
            .| ||.:.|    :....|.|.::.|...||..|:...|           .|......|.: |..
  Fly   571 QG-ERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTE-----------IFAAQLNRGYM-NLP 622

  Fly   679 DFFHAYNCSVGSGMRPGAK 697
            :|..|:.|.....|.|.::
  Fly   623 EFQEAFKCGAEKAMNPPSR 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	146/750 (19%)
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	9/21 (43%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	15/75 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930